Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2B1
  • Mouse genes Eif2b1
  • Rat genes Eif2b1
  • Zfish genes eif2b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	Eif2b1	IDA		Rat	PMID:3818593|RGD:1581069
Molecular Function	GO:0005525	GTP binding	Eif2b1	IMP		Rat	PMID:3818593|RGD:1581069
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EIF2B1	IDA		Human	PMID:11323413
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Eif2b1	IDA		Rat	PMID:9631509|RGD:11041878
Molecular Function	GO:0042802	identical protein binding	EIF2B1	IPI	UniProtKB:Q14232	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	EIF2B1	IPI	UniProtKB:Q14232	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	EIF2B1	IPI	UniProtKB:Q14232	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	EIF2B1	IPI	UniProtKB:Q14232	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q7Z3Z2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9H8Y8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9H8Y8	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q7Z3Z2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q96HA8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9H8Y8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q7Z3Z2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q8IWR1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q8N7C3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9BV19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9NX70	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q9Y2D1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:P30545	Human	PMID:9235896
Molecular Function	GO:0005515	protein binding	EIF2B1	IPI	UniProtKB:Q01338	Human	PMID:9235896
Molecular Function	GO:0005515	protein binding	Eif2b1	IPI	PR:P45481	Mouse	PMID:15752756
Molecular Function	GO:0003743	translation initiation factor activity	EIF2B1	IDA		Human	PMID:16289705
Molecular Function	GO:0003743	translation initiation factor activity	Eif2b1	IDA		Rat	PMID:3818593|RGD:1581069
Molecular Function	GO:0003743	translation initiation factor activity	Eif2b1	IDA		Rat	PMID:9798914|RGD:1581077
Cellular Component	GO:0005737	cytoplasm	EIF2B1	IDA		Human	PMID:11323413
Cellular Component	GO:0005737	cytoplasm	EIF2B1	IDA		Human	PMID:9235896
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	Eif2b1	IDA		Rat	PMID:3818593|RGD:1581069
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1	IDA		Human	PMID:11323413
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1	IDA		Human	PMID:15060152
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	Eif2b1	IDA		Rat	PMID:9631509|RGD:11041878
Cellular Component	GO:0016020	membrane	EIF2B1	IDA		Human	PMID:9235896
Cellular Component	GO:0005886	plasma membrane	EIF2B1	IDA		Human	PMID:9235896
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	Eif2b1	IDA		Rat	PMID:9582312|RGD:1581075
Biological Process	GO:0014003	oligodendrocyte development	EIF2B1	IMP		Human	PMID:15217090
Biological Process	GO:1990928	response to amino acid starvation	Eif2b1	IDA		Rat	PMID:11500297|RGD:1581065
Biological Process	GO:0009749	response to glucose	Eif2b1	IDA		Rat	PMID:8567668|RGD:8554699
Biological Process	GO:0009408	response to heat	Eif2b1	IDA		Rat	PMID:9341116|RGD:8554311
Biological Process	GO:0043434	response to peptide hormone	Eif2b1	IDA		Rat	PMID:8430778|RGD:8553606
Biological Process	GO:0050852	T cell receptor signaling pathway	EIF2B1	IDA		Human	PMID:8626696
Biological Process	GO:0006412	translation	Eif2b1	IDA		Rat	PMID:3818593|RGD:1581069
Biological Process	GO:0006413	translational initiation	EIF2B1	IDA		Human	PMID:16289705
Biological Process	GO:0006413	translational initiation	Eif2b1	IDA		Rat	PMID:3818593|RGD:1581069

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern