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Eif2b1 Gene Detail
Summary
  • Symbol
    Eif2b1
  • Name
    eukaryotic translation initiation factor 2B, subunit alpha
  • Synonyms
    26kDa, D5Ertd406e, EIF2B, EIF2BA, MGC:6458
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384802
    NCBI Gene: 209354
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124708277-124717194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384802
 protein coding gene Chr5:124708276-124717194 (-)
129S1/SvImJ ENSMUSG00200024318
 protein coding gene Chr5:118439613-118439940 (-)
A/J ENSMUSG00195011266
 protein coding gene Chr5:117961218-117961545 (-)
AKR/J ENSMUSG00220037715
 protein coding gene Chr5:117470872-117471200 (-)
AKR/J ENSMUSGG00220054512
 protein coding gene Chr5:117468979-117471160 (-)
BALB/cJ ENSMUSG00180036625
 protein coding gene Chr5:118076122-118076449 (-)
C3H/HeJ ENSMUSG00175024977
 protein coding gene Chr5:120077069-120077397 (-)
C3H/HeJ ENSMUSGG00175054562
 protein coding gene Chr5:120075176-120077357 (-)
C57BL/6NJ ENSMUSGG00215055371
 protein coding gene Chr5:118124030-118126211 (-)
C57BL/6NJ ENSMUSG00215017624
 protein coding gene Chr5:118125923-118126251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027756
 protein coding gene Chr5:117582737-117592268 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210010080
 protein coding gene Chr5:118828031-118828359 (-)
CBA/J ENSMUSGG00210055057
 protein coding gene Chr5:118826138-118828319 (-)
DBA/2J ENSMUSG00185006835
 protein coding gene Chr5:121879100-121879428 (-)
DBA/2J ENSMUSGG00185057741
 protein coding gene Chr5:121877207-121879388 (-)
FVB/NJ ENSMUSGG00205054613
 protein coding gene Chr5:117751935-117754116 (-)
FVB/NJ ENSMUSG00205044438
 protein coding gene Chr5:117753828-117754156 (-)
JF1/MsJ ENSUMUGG00000058375
 protein coding gene Chr5:124728574-124738309 (-)
LP/J ENSMUSG00230039978
 protein coding gene Chr5:125961475-125961802 (-)
NOD/ShiLtJ ENSMUSGG00190054642
 protein coding gene Chr5:117751554-117753735 (-)
NOD/ShiLtJ ENSMUSG00190041220
 protein coding gene Chr5:117753447-117753775 (-)
NZO/HlLtJ ENSMUSG00225013761
 protein coding gene Chr5:133658682-133659010 (-)
NZO/HlLtJ ENSMUSGG00225055459
 protein coding gene Chr5:133656789-133658970 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010036467
 protein coding gene Chr5:119923087-119931267 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
  • Synonyms
    EIF2B, EIF2BA, EIF2Balpha, VWM1
  • Links
    NCBI Gene ID: 1967
    UniProt: Q14232

  • Chr Location
    12q24.31; chr12:123620406-123633766 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF2B1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    86
  • cDNA Data
    160
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209354 NCBI Gene Model | MGI Sequence Detail 8918 C57BL/6J ±  kb
transcript NM_145371 RefSeq | MGI Sequence Detail 2012 C57BL/6  
polypeptide Q99LC8 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006962 translation initiation factor eIF2B subunit alpha
    (term hierarchy)
  • InterPro Domains
    IPR051501 Eukaryotic initiation factor 2B subunits alpha/beta/delta
    IPR042529 Initiation factor 2B-like, C-terminal
    IPR000649 Initiation factor 2B-related
    IPR037171 NagB/RpiA transferase-like
    IPR042528 Translation initiation factor eIF-2B subunit alpha, N-terminal
  • GlyGen
    Q99LC8 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 163
    cDNA 160
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196215
References
more
  • Summaries
    All 58
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:371888 Lin K, et al., Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease. JCI Insight. 2025 Aug 22;10(16)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory