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Eif2b1
Gene Detail
 Symbol
Name
ID
Eif2b1
eukaryotic translation initiation factor 2B, subunit 1 (alpha)
MGI:2384802
Synonyms 26kDa, D5Ertd406e, EIF2B, EIF2BA, MGC:6458
Feature Type protein coding gene
Genetic Map
Chromosome 5
63.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:124570213-124579131 bp, - strand
From VEGA annotation of GRCm38

  8919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Eif2b1

Human
homologs
Human Homolog EIF2B1, eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
NCBI Gene ID 1967
neXtProt AC  NX_Q14232
Human Synonyms  EIF2B, EIF2BA
Human Chr (Location)  12q24.31; chr12:123621023-123633776 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Eif2b1 interacts with 102 markers (Mir7-1, Mir20a, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular metabolic process, cellular response to stimulus, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex, ...
Function enzyme regulator activity, GDP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (196)    Tissues (86)    Images (35)
Theiler Stages: 15, 19, 23, 28
Assay TypeResults
RNA in situ 194
RT-PCR 2
cDNA source data(159)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(162) cDNA(159) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024473 (Evidence)
Ensembl Gene ModelENSMUSG00000029388 (Evidence)
Entrez Gene209354 (Evidence)
UniGene28839
DFCITC1572720
DoTSDT.495353, DT.91309192
NIA Mouse Gene IndexU026738
Consensus CDS ProjectCCDS39282.1
International Mouse Knockout Project StatusEif2b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024473 VEGA Gene Model | MGI Sequence Detail 8919 C57BL/6J ±  kb
transcript OTTMUST00000060023 VEGA | MGI Sequence Detail 2013 Not Applicable 
polypeptide OTTMUSP00000029257 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000649 Initiation factor 2B-related
Protein Ontology PR:000006962 translation initiation factor eIF-2B subunit alpha
References (Earliest) J:41995 Klein U, et al., A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. J Biol Chem. 1997 Aug 1;272(31):19099-102
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGI:1196215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory