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Eif2b1 Gene Detail
Summary
  • Symbol
    Eif2b1
  • Name
    eukaryotic translation initiation factor 2B, subunit 1 (alpha)
  • Synonyms
    26kDa, D5Ertd406e, EIF2B, EIF2BA, MGC:6458
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384802
    NCBI Gene: 209354
  • Gene Overview
    MyGene.info: EIF2B1
Location & Maps
more
  • Sequence Map
    Chr5:124570213-124579131 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8919 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    EIF2B, EIF2BA
  • Links
    NCBI Gene ID: 1967
    neXtProt AC: NX_Q14232

  • Chr Location
    12q24.31; chr12:123621023-123633776 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1080
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: EIF2B1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EIF2B1 associations

Human Disease Mouse Models
       Leukoencephalopathy with Vanishing White Matter; VWM   OMIM: 603896
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Eif2b1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024473 VEGA Gene Model | MGI Sequence Detail 8919 C57BL/6J ±  kb
transcript OTTMUST00000060023 VEGA | MGI Sequence Detail 2013 Not Applicable  
polypeptide OTTMUSP00000029257 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    119 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006962 translation initiation factor eIF-2B subunit alpha
  • InterPro Domains
    IPR000649 Initiation factor 2B-related
Molecular
Reagents
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  • All nucleic 162
    cDNA 159
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1196215
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:41995 Klein U, et al., A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. J Biol Chem. 1997 Aug 1;272(31):19099-102
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory