Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dyrk1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DYRK1A
- Mouse genes Dyrk1a
- Rat genes Dyrk1a
- Zfish genes dyrk1aa,dyrk1ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dyrk1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140857	histone H3T45 kinase activity	DYRK1A	IDA		Human	PMID:24820035
Molecular Function	GO:0042802	identical protein binding	Dyrk1a	IPI	UniProtKB:Q61214	Mouse	MGI:MGI:5297623\|PMID:21965663
Molecular Function	GO:0042802	identical protein binding	Dyrk1a	IPI	UniProtKB:Q61214	Mouse	MGI:MGI:86016\|PMID:9070862
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	DYRK1A	IDA		Human	PMID:9748265
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q96S59	Human	PMID:14500717
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:14593110
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q92561	Human	PMID:15694837
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q7Z698	Human	PMID:20736167
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q7Z699	Human	PMID:20736167
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:20940704
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P06400	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P28749	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q12815	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q9BRK4	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q12815	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q9BRK4	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:Q5T749	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P06400	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P28749	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DYRK1A	IPI	UniProtKB:P61962	Human	PMID:35016035
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	UniProtKB:P53805-2\|UniProtKB:Q9JHG6	Mouse	MGI:MGI:5297623\|PMID:21965663
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:4838949\|PMID:20167603
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	UniProtKB:Q9R194	Mouse	MGI:MGI:4461092\|PMID:20123978
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	UniProtKB:O43597\|UniProtKB:Q924S7\|UniProtKB:Q924S8	Mouse	MGI:MGI:5318016\|PMID:20736167
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	PR:Q62093	Mouse	PMID:21470964
Molecular Function	GO:0005515	protein binding	Dyrk1a	IPI	PR:Q99NG0	Mouse	PMID:15199138
Molecular Function	GO:0004672	protein kinase activity	Dyrk1a	IDA		Rat	PMID:11877424\|RGD:625468
Molecular Function	GO:0043621	protein self-association	Dyrk1a	IPI	UniProtKB:Q61214	Mouse	MGI:MGI:86016\|PMID:9070862
Molecular Function	GO:0106310	protein serine kinase activity	DYRK1A	IDA		Human	PMID:30773093
Molecular Function	GO:0004674	protein serine/threonine kinase activity	DYRK1A	IGI	UniProtKB:Q61214	Human	PMID:17906291
Molecular Function	GO:0004674	protein serine/threonine kinase activity	DYRK1A	IGI	UniProtKB:Q9Y463	Human	PMID:25556849
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Dyrk1a	IDA		Mouse	MGI:MGI:5318016\|PMID:20736167
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Dyrk1a	IDA		Mouse	MGI:MGI:4461092\|PMID:20123978
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Dyrk1a	IGI	UniProtKB:Q13627	Mouse	MGI:MGI:3768476\|PMID:17906291
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Dyrk1a	IGI	UniProtKB:A0A0G2KAP6,UniProtKB:D4ACC4	Rat	PMID:25556849\|RGD:13507302
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Dyrk1a	IDA		Rat	PMID:8631952\|RGD:728738
Molecular Function	GO:0004713	protein tyrosine kinase activity	Dyrk1a	IDA		Rat	PMID:8631952\|RGD:728738
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	DYRK1A	IDA		Human	PMID:25620562
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	DYRK1A	IDA		Human	PMID:29849146
Molecular Function	GO:0048156	tau protein binding	Dyrk1a	IPI	UniProtKB:P10637	Mouse	MGI:MGI:3768476\|PMID:17906291
Molecular Function	GO:0048156	tau protein binding	Dyrk1a	IPI	UniProtKB:P10637	Mouse	MGI:MGI:5318016\|PMID:20736167
Cellular Component	GO:0030424	axon	Dyrk1a	IDA		Mouse	MGI:MGI:5316575\|PMID:21878370
Cellular Component	GO:0005737	cytoplasm	DYRK1A	IDA		Human	PMID:15694837
Cellular Component	GO:0005737	cytoplasm	Dyrk1a	IDA		Mouse	MGI:MGI:5316575\|PMID:21878370
Cellular Component	GO:0005856	cytoskeleton	DYRK1A	IDA		Human	PMID:24327345
Cellular Component	GO:0005856	cytoskeleton	Dyrk1a	IDA		Mouse	MGI:MGI:6107410\|PMID:24327345
Cellular Component	GO:0030425	dendrite	Dyrk1a	IDA		Mouse	MGI:MGI:5316575\|PMID:21878370
Cellular Component	GO:0016607	nuclear speck	Dyrk1a	IDA		Rat	PMID:22767602\|RGD:8554210
Cellular Component	GO:0016607	nuclear speck	Dyrk1a	IDA		Rat	PMID:9748265\|RGD:8554265
Cellular Component	GO:0005634	nucleus	DYRK1A	IDA		Human	PMID:25620562
Cellular Component	GO:0005634	nucleus	DYRK1A	IDA		Human	PMID:15694837
Cellular Component	GO:0005634	nucleus	DYRK1A	IDA		Human	PMID:23415227
Cellular Component	GO:0005634	nucleus	Dyrk1a	IDA		Mouse	MGI:MGI:86016\|PMID:9070862
Cellular Component	GO:0005634	nucleus	Dyrk1a	IDA		Mouse	MGI:MGI:5316575\|PMID:21878370
Cellular Component	GO:0005634	nucleus	Dyrk1a	IDA		Rat	PMID:9748265\|RGD:8554265
Cellular Component	GO:1990904	ribonucleoprotein complex	Dyrk1a	IDA		Mouse	PMID:21709260
Biological Process	GO:0034205	amyloid-beta formation	DYRK1A	IMP		Human	PMID:25556849
Biological Process	GO:0001525	angiogenesis	dyrk1aa	IMP	ZFIN:ZDB-GENO-181213-9	Zfish	PMID:31043432
Biological Process	GO:0007420	brain development	dyrk1aa	IMP	ZFIN:ZDB-GENO-181213-9	Zfish	PMID:29021890
Biological Process	GO:0007623	circadian rhythm	Dyrk1a	IMP		Mouse	MGI:MGI:4461092\|PMID:20123978
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Dyrk1a	IDA		Mouse	MGI:MGI:5318016\|PMID:20736167
Biological Process	GO:0090310	negative regulation of DNA methylation-dependent heterochromatin formation	DYRK1A	IDA		Human	PMID:24820035
Biological Process	GO:0031115	negative regulation of microtubule polymerization	Dyrk1a	IDA		Mouse	MGI:MGI:3768476\|PMID:17906291
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	Dyrk1a	IMP		Mouse	PMID:21470964
Biological Process	GO:0018105	peptidyl-serine phosphorylation	DYRK1A	IGI	UniProtKB:Q9Y463	Human	PMID:25556849
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Dyrk1a	IDA		Mouse	MGI:MGI:4461092\|PMID:20123978
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Dyrk1a	IDA		Rat	PMID:21215488\|RGD:13464256
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Dyrk1a	IDA		Rat	PMID:22767602\|RGD:8554210
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Dyrk1a	IGI	UniProtKB:A0A0G2KAP6,UniProtKB:D4ACC4	Rat	PMID:25556849\|RGD:13507302
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Dyrk1a	IDA		Mouse	MGI:MGI:5318016\|PMID:20736167
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Dyrk1a	IGI	UniProtKB:A0A0G2KAP6,UniProtKB:D4ACC4	Rat	PMID:25556849\|RGD:13507302
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	DYRK1A	IDA		Human	PMID:24327345
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	Dyrk1a	IDA		Mouse	MGI:MGI:6107410\|PMID:24327345
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	DYRK1A	IDA		Human	PMID:9748265
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Dyrk1a	IDA		Mouse	PMID:21470964
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Dyrk1a	IDA		Rat	PMID:8631952\|RGD:728738
Biological Process	GO:0090312	positive regulation of protein deacetylation	Dyrk1a	IDA		Mouse	MGI:MGI:5318016\|PMID:20736167
Biological Process	GO:0033120	positive regulation of RNA splicing	DYRK1A	IDA		Human	PMID:28377597
Biological Process	GO:0033120	positive regulation of RNA splicing	Dyrk1a	IMP		Rat	PMID:28377597\|RGD:13464257
Biological Process	GO:0046777	protein autophosphorylation	Dyrk1a	IDA		Rat	PMID:8631952\|RGD:728738
Biological Process	GO:0006468	protein phosphorylation	Dyrk1a	IDA		Rat	PMID:11877424\|RGD:625468
Biological Process	GO:0006468	protein phosphorylation	Dyrk1a	IDA		Rat	PMID:8631952\|RGD:728738
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Dyrk1a	IDA		Rat	PMID:22767602\|RGD:8554210

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.