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Dyrk1a Gene Detail
Summary
  • Symbol
    Dyrk1a
  • Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
  • Synonyms
    2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330299
    NCBI Gene: 13548
  • Gene Overview
    MyGene.info: DYRK1A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94570010-94695517 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 55.30 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330299
protein coding gene Chr16:94569455-94695519 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023073
protein coding gene Chr16:95816066-95947815 (+)
A/J MGP_AJ_G0023041
protein coding gene Chr16:91309129-91434240 (+)
AKR/J MGP_AKRJ_G0023011
protein coding gene Chr16:94111552-94235668 (+)
BALB/cJ MGP_BALBcJ_G0023043
protein coding gene Chr16:91847017-91972307 (+)
C3H/HeJ MGP_C3HHeJ_G0022804
protein coding gene Chr16:94625168-94752511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023490
protein coding gene Chr16:98874331-99012808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020992
protein coding gene Chr16:89166533-89288454 (+)
CAST/EiJ MGP_CASTEiJ_G0022323
protein coding gene Chr16:95379835-95511912 (+)
CBA/J MGP_CBAJ_G0022773
protein coding gene Chr16:103142715-103268542 (+)
DBA/2J MGP_DBA2J_G0022907
protein coding gene Chr16:91200327-91326431 (+)
FVB/NJ MGP_FVBNJ_G0022881
protein coding gene Chr16:90361514-90486422 (+)
LP/J MGP_LPJ_G0022977
protein coding gene Chr16:95476887-95608065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022902
protein coding gene Chr16:107466812-107596159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023508
protein coding gene Chr16:94634094-94763071 (+)
PWK/PhJ MGP_PWKPhJ_G0022068
protein coding gene Chr16:91466746-91592981 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021898
protein coding gene Chr16:94173160-94305770 (+)
WSB/EiJ MGP_WSBEiJ_G0022374
protein coding gene Chr16:94887744-95017007 (+)



Homology
more
  • Human Ortholog
    DYRK1A, dual specificity tyrosine phosphorylation regulated kinase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DYRK1A, dual specificity tyrosine phosphorylation regulated kinase 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DYRK, DYRK1, HP86, MNB, MNBH, MRD7
  • Links
    NCBI Gene ID: 1859
    neXtProt AC: NX_Q13627
    UniProt: Q13627

  • Chr Location
    21q22.13; chr21:37365790-37515376 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55576
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DYRK1A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Dyrk1a mouse models; 1 with human DYRK1A associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 4 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted deletion present a general embryonic growth delay and die during midgestation. Heterozygotes display reduced postnatal survival, postnatal growth retardation, microcephaly, behavioral and motor deficits, and altered neocortical pyramidal cell morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022897 Ensembl Gene Model | MGI Sequence Detail 125508 C57BL/6J ±  kb
    transcript ENSMUST00000023614 Ensembl | MGI Sequence Detail 5754 Not Applicable  
    polypeptide ENSMUSP00000023614 Ensembl | MGI Sequence Detail 763 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 5
      cDNA 140
      Primer pair 7
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28072, MGD-MRK-38315, MGI:104780, MGI:109270, MGI:1196299, MGI:1277155, MGI:1923715
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 23
      Diseases 7
      Gene Ontology 17
      Phenotypes 71
    • Earliest
      J:29230 Patil N, et al., A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments]. Nat Genet. 1995 Oct;11(2):126-9
    • Latest
      J:262731 Neumann F, et al., DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory