Dyrk1a
Gene Detail

Symbol Name ID

Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a MGI:1330299

Synonyms

2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh

Feature Type

protein coding gene

Genetic Map

Chromosome 16

55.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr16:94570010-94695067 bp, + strand From VEGA annotation of GRCm38   125058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55576  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dyrk1a

Human homologs

Human Homolog		DYRK1A, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
NCBI Gene ID		1859
neXtProt AC		NX_Q13627
Human Synonyms		DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Human Chr (Location)		21q22.13; chr21:38739859-38887679 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DYRK1A

Alleles and phenotypes

All alleles(133) : Targeted(3) Gene trapped(130)
 

Mice homozygous for a targeted deletion present a general embryonic growth delay and die during midgestation. Heterozygotes display reduced postnatal survival, postnatal growth retardation, microcephaly, behavioral and motor deficits, and altered neocortical pyramidal cell morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	circadian rhythm, negative regulation of DNA damage response, signal transduction by p53 class mediator, ...
Component	nuclear speck, nucleolus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (223)    Tissues (121)    Images (18)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	156
Northern blot	27
Western blot	3
RT-PCR	37

cDNA source data(133)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(148) Genomic(5) cDNA(134) Primer pair(7) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028435 (Evidence)
Ensembl Gene Model	ENSMUSG00000022897 (Evidence)
Entrez Gene	13548 (Evidence)
UniGene	310973
DFCI	TC1582103, TC1627821, TC1687400, TC1693958, TC1697621
DoTS	DT.110720525, DT.110720549, DT.534324, DT.99855281
NIA Mouse Gene Index	U017413
EC	2.7.12.1
Consensus CDS Project	CCDS28350.1
International Mouse Knockout Project Status	Dyrk1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028435	VEGA Gene Model | MGI Sequence Detail	125058	C57BL/6J
transcript	OTTMUST00000070459	VEGA | MGI Sequence Detail	5759	Not Applicable
polypeptide	OTTMUSP00000035913	VEGA | MGI Sequence Detail	763	Not Applicable

All sequences(69) RefSeq(4) UniProt(9)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(357 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000006781	dual specificity tyrosine-phosphorylation-regulated kinase 1A

References

(Earliest) J:29230 Patil N, et al., A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments]. Nat Genet. 1995 Oct;11(2):126-9
(Latest) J:187626 Park JH, et al., Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11alpha. J Neurochem. 2012 Sep;122(5):1081-91
All references(83)

Other accession IDs

MGD-MRK-28072, MGD-MRK-38315, MGI:104780, MGI:109270, MGI:1196299, MGI:1277155, MGI:1923715