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Dyrk1a
Gene Detail
Symbol

Name
ID
Dyrk1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
MGI:1330299
Synonyms
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh
Feature Type
protein coding gene
Genetic Map
Chromosome 16
55.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:94570010-94695067 bp, + strand
From VEGA annotation of GRCm38

  125058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55576  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dyrk1a

Human
homologs
Human Homolog DYRK1A, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
NCBI Gene ID 1859
neXtProt AC  NX_Q13627
Human Synonyms  DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Human Chr (Location)  21q22.13; chr21:37365790-37515376 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DYRK1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(135) : Gene trapped(130) Targeted(5)
Genomic Mutations involving Dyrk1a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted deletion present a general embryonic growth delay and die during midgestation. Heterozygotes display reduced postnatal survival, postnatal growth retardation, microcephaly, behavioral and motor deficits, and altered neocortical pyramidal cell morphology.
 
Interactions
Dyrk1a interacts with 465 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process circadian rhythm, negative regulation of DNA damage response, signal transduction by p53 class mediator, ...
Component nuclear speck, nucleus, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (223)    Tissues (122)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
Northern blot 27
Western blot 3
RT-PCR 37
cDNA source data(138)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) Genomic(5) cDNA(139) Primer pair(7) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028435 (Evidence)
Ensembl Gene ModelENSMUSG00000022897 (Evidence)
Entrez Gene13548 (Evidence)
UniGene310973
DFCITC1582103, TC1627821, TC1687400, TC1693958, TC1697621
DoTSDT.110720525, DT.110720549, DT.534324, DT.99855281
NIA Mouse Gene IndexU017413
EC2.7.12.1
Consensus CDS ProjectCCDS28350.1
International Mouse Knockout Project StatusDyrk1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028435 VEGA Gene Model | MGI Sequence Detail 125058 C57BL/6J ±  kb
transcript OTTMUST00000070459 VEGA | MGI Sequence Detail 5759 Not Applicable 
polypeptide OTTMUSP00000035913 VEGA | MGI Sequence Detail 763 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(9)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(515 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006781 dual specificity tyrosine-phosphorylation-regulated kinase 1A
References
(Earliest) J:29230 Patil N, et al., A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments]. Nat Genet. 1995 Oct;11(2):126-9
(Latest) J:210093 Rachdi L, et al., Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass. Diabetologia. 2014 May;57(5):960-9
All references(86)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-28072, MGD-MRK-38315, MGI:104780, MGI:109270, MGI:1196299, MGI:1277155, MGI:1923715

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory