Gene Expression Literature Summary

• Symbol: Dyrk1a
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
• ID: MGI:1330299

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19	E20	E	P
Immunohistochemistry (section)							2			2				2	2	1	1				1				7
In situ RNA (section)			1	2	1	1	1		1	2	1	1	2	4	1	2	1	1	1		1				4
In situ RNA (whole mount)		1	2	1	2		3																	1
Northern blot	2							2							2			2							1
Western blot							2		1		2	1		1	1			1		1	1		1		8
RT-PCR			1		2			1	1	2	1	4		1	2	2		2	2		2	1			12
cDNA clones																		1							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dyrk1a  dual-specificity tyrosine phosphorylation regulated kinase 1a   (Synonyms: 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh)
Results	Reference
2	J:109139 Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR, NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006 Jun 1;441(7093):595-600
3	J:316661 Barallobre MJ, Perier C, Bove J, Laguna A, Delabar JM, Vila M, Arbones ML, DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. Cell Death Dis. 2014 Jun 12;5:e1289
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:294517 Billingsley CN, Allen JR, Baumann DD, Deitz SL, Blazek JD, Newbauer A, Darrah A, Long BC, Young B, Clement M, Doerge RW, Roper RJ, Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome. Am J Med Genet A. 2013 Aug;161A(8):1866-74
1	J:217672 Blazek JD, Malik AM, Tischbein M, Arbones ML, Moore CS, Roper RJ, Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Mech Dev. 2015 May;136:133-42
4	J:311493 Brault V, Nguyen TL, Flores-Gutierrez J, Iacono G, Birling MC, Lalanne V, Meziane H, Manousopoulou A, Pavlovic G, Lindner L, Selloum M, Sorg T, Yu E, Garbis SD, Herault Y, Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome. PLoS Genet. 2021 Sep;17(9):e1009777
1*	J:150493 Fernandez-Martinez J, Vela EM, Tora-Ponsioen M, Ocana OH, Nieto MA, Galceran J, Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. J Cell Sci. 2009 May 15;122(Pt 10):1574-83
3	J:164437 Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sanchez P, Arbones ML, Farinas I, Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010 Sep 3;7(3):367-79
7*	J:67406 Geiger JN, Knudsen GT, Panek L, Pandit AK, Yoder MD, Lord KA, Creasy CL, Burns BM, Gaines P, Dillon SB, Wojchowski DM, mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Blood. 2001 Feb 15;97(4):901-10
3*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
2	J:182294 Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM, DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis. 2012 Apr;46(1):190-203
20	J:133208 Hammerle B, Elizalde C, Tejedor FJ, The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. Eur J Neurosci. 2008 Mar;27(5):1061-74
4	J:77263 Hammerle B, Vera-Samper E, Speicher S, Arencibia R, Martinez S, Tejedor FJ, Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions. Dev Biol. 2002 Jun 15;246(2):259-73
3	J:343255 Hawley LE, Stringer M, Deal AJ, Folz A, Goodlett CR, Roper RJ, Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model. Neurobiol Dis. 2023 Nov 20;190:106359
4	J:221510 Kariyawasam D, Rachdi L, Carre A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M, DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome. Endocrinology. 2015 Mar;156(3):1171-80
3*	J:112895 Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, Kim NS, Kim YH, Kim JK, Ahn KY, Kim KK, A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13074-9
3*	J:205486 Kurabayashi N, Sanada K, Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013 Dec 15;27(24):2708-21
5	J:144220 Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernandez E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbones ML, The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell. 2008 Dec;15(6):841-53
2	J:345472 Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, Flynn H, Gilmore T, Watson-Scales S, Haugsten Hansen M, Hayward D, Song OR, Brault V, Herault Y, Deau E, Meijer L, Snijders AP, Gutierrez MG, Fisher EMC, Tybulewicz VLJ, Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
5	J:146836 Lepagnol-Bestel AM, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, Imbeaud S, Loe-Mie Y, Benihoud K, Agier N, Salin PA, Cardona A, Khung-Savatovsky S, Kallunki P, Delabar JM, Puskas LG, Delacroix H, Aggerbeck L, Delezoide AL, Delattre O, Gorwood P,Moalic JM, Simonneau M, DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum Mol Genet. 2009 Apr 15;18(8):1405-14
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*	J:241781 McElyea SD, Starbuck JM, Tumbleson-Brink DM, Harrington E, Blazek JD, Ghoneima A, Kula K, Roper RJ, Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome. Hum Mol Genet. 2016 Nov 15;25(22):4856-4869
3	J:240247 Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G, TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 Aug;26(8):1013-22
2	J:166796 Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC, Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906
2	J:331420 Pijuan I, Balducci E, Soto-Sanchez C, Fernandez E, Barallobre MJ, Arbones ML, Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome. Sci Rep. 2022 Nov 19;12(1):19912
5	J:210093 Rachdi L, Kariyawasam D, Guez F, Aiello V, Arbones ML, Janel N, Delabar JM, Polak M, Scharfmann R, Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass. Diabetologia. 2014 May;57(5):960-9
4*	J:51574 Rahmani Z, Lopes C, Rachidi M, Delabar JM, Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues. Biochem Biophys Res Commun. 1998 Dec 18;253(2):514-8
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
14*	J:37711 Song WJ, Sternberg LR, Kasten-Sportes C, Keuren ML, Chung SH, Slack AC, Miller DE, Glover TW, Chiang PW, Lou L, Kurnit DM, Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome critical region. Genomics. 1996 Dec 15;38(3):331-9
1	J:162596 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J, TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010 Apr 30;285(18):13721-35
3*	J:319245 Wang P, Wang L, Chen L, Sun X, Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D. Sci Rep. 2017 Aug 3;7(1):7240
1	J:312414 Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K, Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204