Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUOX1
  • Mouse genes Duox1
  • Rat genes Duox1
  • Zfish genes duox
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Duox1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DUOX1	IPI	UniProtKB:Q1HG43-2	Human	PMID:19339556
Molecular Function	GO:0005515	protein binding	DUOX1	IPI	UniProtKB:Q1HG43-3	Human	PMID:19339556
Molecular Function	GO:0005515	protein binding	DUOX1	IPI	UniProtKB:Q1HG44	Human	PMID:19339556
Molecular Function	GO:0005515	protein binding	Duox1	IPI	PR:Q8VE49	Mouse	PMID:20233719
Cellular Component	GO:0031252	cell leading edge	DUOX1	IGI	UniProtKB:Q1HG43-2	Human	PMID:19339556
Cellular Component	GO:0009986	cell surface	DUOX1	IGI	UniProtKB:Q1HG43	Human	PMID:22814254
Cellular Component	GO:0009986	cell surface	DUOX1	IGI	UniProtKB:Q1HG44	Human	PMID:22814254
Cellular Component	GO:0005783	endoplasmic reticulum	DUOX1	IDA		Human	PMID:19339556
Cellular Component	GO:0005886	plasma membrane	DUOX1	IDA		Human	PMID:19339556
Cellular Component	GO:0005886	plasma membrane	Duox1	IDA		Mouse	PMID:20233719
Biological Process	GO:0042335	cuticle development	DUOX1	IMP		Human	PMID:11514595
Biological Process	GO:0019221	cytokine-mediated signaling pathway	DUOX1	IDA		Human	PMID:16111680
Biological Process	GO:0050832	defense response to fungus	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:24098114
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX1	IGI	UniProtKB:Q1HG43	Human	PMID:19339556
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX1	IGI	UniProtKB:Q1HG43	Human	PMID:22814254
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0048246	macrophage chemotaxis	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:25488917
Biological Process	GO:0030593	neutrophil chemotaxis	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:24842759
Biological Process	GO:2000147	positive regulation of cell motility	DUOX1	IGI	UniProtKB:Q1HG43-2	Human	PMID:19339556
Biological Process	GO:0090303	positive regulation of wound healing	DUOX1	IGI	UniProtKB:Q1HG43-2	Human	PMID:19339556
Biological Process	GO:0072593	reactive oxygen species metabolic process	Duox1	IGI	MGI:MGI:2384861	Mouse	PMID:20233719
Biological Process	GO:0009617	response to bacterium	duox	IMP	ZFIN:ZDB-MRPHLNO-100902-1	Zfish	PMID:20709024
Biological Process	GO:0051591	response to cAMP	DUOX1	IDA		Human	PMID:15062544
Biological Process	GO:0009611	response to wounding	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-3	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-1	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-4	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-2	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-190722-9	Zfish	PMID:30700401
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-4	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-1	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-3	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-2	Zfish	PMID:31678421

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern