About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:thyroid hormone generation
GO id:GO:0006590
Definition:The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
CommentsNote that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological quality
                                is-aregulation of hormone levels
                                        is-ahormone metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-aphenol-containing compound metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aorganic acid metabolic process
                                        is-aoxoacid metabolic process
                                                is-acarboxylic acid metabolic process
                                                        is-acellular amino acid metabolic process
                                                                is-acellular modified amino acid metabolic process
                                                                        is-athyroid hormone metabolic process
                                                                                is-athyroid hormone catabolic process
                                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-aorganic acid metabolic process
                                        is-aoxoacid metabolic process
                                                is-acarboxylic acid metabolic process
                                                        is-acellular amino acid metabolic process
                                                                is-acellular modified amino acid metabolic process
                                                                        is-athyroid hormone metabolic process
                                                                                is-athyroid hormone catabolic process
                                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-aphenol-containing compound metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aorganic acid metabolic process
                                        is-aoxoacid metabolic process
                                                is-acarboxylic acid metabolic process
                                                        is-acellular amino acid metabolic process
                                                                is-acellular modified amino acid metabolic process
                                                                        is-athyroid hormone metabolic process
                                                                                is-athyroid hormone catabolic process
                                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-ahormone metabolic process
                                is-athyroid hormone metabolic process
                                        is-athyroid hormone catabolic process
                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                positively-regulatespositive regulation of thyroid hormone generation
                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-acellular amino acid metabolic process
                                                is-acellular modified amino acid metabolic process
                                                        is-athyroid hormone metabolic process
                                                                is-athyroid hormone catabolic process
                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic acid metabolic process
                                        is-aoxoacid metabolic process
                                                is-acarboxylic acid metabolic process
                                                        is-acellular amino acid metabolic process
                                                                is-acellular modified amino acid metabolic process
                                                                        is-athyroid hormone metabolic process
                                                                                is-athyroid hormone catabolic process
                                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-aphenol-containing compound metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic hydroxy compound metabolic process
                                        is-aphenol-containing compound metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-acellular amino acid metabolic process
                                                is-acellular modified amino acid metabolic process
                                                        is-athyroid hormone metabolic process
                                                                is-athyroid hormone catabolic process
                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-acellular amino acid metabolic process
                                        is-acellular modified amino acid metabolic process
                                                is-athyroid hormone metabolic process
                                                        is-athyroid hormone catabolic process
                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asmall molecule metabolic process
                                        is-aorganic acid metabolic process
                                                is-aoxoacid metabolic process
                                                        is-acarboxylic acid metabolic process
                                                                is-acellular amino acid metabolic process
                                                                        is-acellular modified amino acid metabolic process
                                                                                is-athyroid hormone metabolic process
                                                                                        is-athyroid hormone catabolic process
                                                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                                                regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-aorganic acid metabolic process
                                        is-aoxoacid metabolic process
                                                is-acarboxylic acid metabolic process
                                                        is-acellular amino acid metabolic process
                                                                is-acellular modified amino acid metabolic process
                                                                        is-athyroid hormone metabolic process
                                                                                is-athyroid hormone catabolic process
                                                                                is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                        negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                        positively-regulatespositive regulation of thyroid hormone generation
                                                                                        regulatesregulation of thyroid hormone generation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asmall molecule metabolic process
                                        is-aorganic acid metabolic process
                                                is-aoxoacid metabolic process
                                                        is-acarboxylic acid metabolic process
                                                                is-acellular amino acid metabolic process
                                                                        is-acellular modified amino acid metabolic process
                                                                                is-athyroid hormone metabolic process
                                                                                        is-athyroid hormone catabolic process
                                                                                        is-athyroid hormone generation [GO:0006590] (13 genes, 15 annotations)
                                                                                                negatively-regulatesnegative regulation of thyroid hormone generation
                                                                                                positively-regulatespositive regulation of thyroid hormone generation
                                                                                                regulatesregulation of thyroid hormone generation +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory