| GO term: | thyroid hormone generation |
| GO id: | GO:0006590 |
| Definition: | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
| Comments | Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. |
| Number of paths to term: | 13 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological qualityregulation of hormone levelshormone metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processcellular processcellular metabolic processcellular aromatic compound metabolic processphenol-containing compound metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processcellular processcellular metabolic processorganic acid metabolic processoxoacid metabolic processcarboxylic acid metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processcellular metabolic processcellular aromatic compound metabolic processphenol-containing compound metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processcellular metabolic processorganic acid metabolic processoxoacid metabolic processcarboxylic acid metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processhormone metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processnitrogen compound metabolic processorganonitrogen compound metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processorganic substance metabolic processcarboxylic acid metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processorganic substance metabolic processorganic cyclic compound metabolic processphenol-containing compound metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processorganic substance metabolic processorganic hydroxy compound metabolic processphenol-containing compound metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processorganic substance metabolic processorganonitrogen compound metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processprimary metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +biological_processmetabolic processsingle-organism metabolic processsmall molecule metabolic processorganic acid metabolic processoxoacid metabolic processcarboxylic acid metabolic processcellular amino acid metabolic processcellular modified amino acid metabolic processthyroid hormone metabolic processthyroid hormone catabolic processthyroid hormone generation [GO:0006590] (10 genes, 12 annotations)negative regulation of thyroid hormone generationpositive regulation of thyroid hormone generationregulation of thyroid hormone generation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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