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Duox1 Gene Detail
Summary
  • Symbol
    Duox1
  • Name
    dual oxidase 1
  • Synonyms
    9930101G15Rik, LNOX1, NOXEF1, THOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139422
    NCBI Gene: 99439
  • Gene Overview
    MyGene.info: DUOX1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:122315672-122347972 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139422
protein coding gene Chr2:122313810-122347972 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026413
protein coding gene Chr2:125317256-125348516 (+)
A/J MGP_AJ_G0026375
protein coding gene Chr2:120191667-120223249 (+)
AKR/J MGP_AKRJ_G0026352
protein coding gene Chr2:123558211-123592633 (+)
BALB/cJ MGP_BALBcJ_G0026387
protein coding gene Chr2:120421383-120454133 (+)
C3H/HeJ MGP_C3HHeJ_G0026132
protein coding gene Chr2:124040596-124074925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026834
protein coding gene Chr2:129383664-129417596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024213
protein coding gene Chr2:115161641-115193869 (+)
CAST/EiJ MGP_CASTEiJ_G0025594
protein coding gene Chr2:124381861-124466810 (+)
CBA/J MGP_CBAJ_G0026111
protein coding gene Chr2:133933907-133974476 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0026210
protein coding gene Chr2:118380943-118412972 (+)
LP/J MGP_LPJ_G0026350
protein coding gene Chr2:125562534-125595344 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026230
protein coding gene Chr2:138144445-138178492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026889
protein coding gene Chr2:123675440-123708210 (+)
PWK/PhJ MGP_PWKPhJ_G0025330
protein coding gene Chr2:119202050-119289781 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025130
protein coding gene Chr2:122818687-122911498 (+)
WSB/EiJ MGP_WSBEiJ_G0025666
protein coding gene Chr2:124536347-124569297 (+)



Homology
more
  • Human Ortholog
    DUOX1, dual oxidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUOX1, dual oxidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LNOX1, NOXEF1, THOX1
  • Links
    NCBI Gene ID: 53905
    neXtProt AC: NX_Q9NRD9
    UniProt: Q9NRD9

  • Chr Location
    15q21.1; chr15:45129994-45165578 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68136
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DUOX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033268 Ensembl Gene Model | MGI Sequence Detail 32301 C57BL/6J ±  kb
transcript ENSMUST00000099461 Ensembl | MGI Sequence Detail 5267 Not Applicable  
polypeptide ENSMUSP00000097060 Ensembl | MGI Sequence Detail 1551 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029595 Dual oxidase 1/Duox
    IPR034821 Dual oxidase, peroxidase domain
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR013112 FAD-binding 8
    IPR017927 FAD-binding domain, ferredoxin reductase-type
    IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
    IPR013121 Ferric reductase, NAD binding domain
    IPR013130 Ferric reductase transmembrane component-like domain
    IPR010255 Haem peroxidase
    IPR019791 Haem peroxidase, animal type
    IPR037120 Haem peroxidase domain superfamily, animal type
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 20
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:238387 Chang S, et al., DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS One. 2015;10(7):e0131810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory