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Duox1 Gene Detail
Summary
  • Symbol
    Duox1
  • Name
    dual oxidase 1
  • Synonyms
    9930101G15Rik, LNOX1, NOXEF1, THOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139422
    NCBI Gene: 99439
  • Gene Overview
    MyGene.info: DUOX1
Location & Maps
more
  • Sequence Map
    Chr2:122315672-122347972 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.63 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DUOX1, dual oxidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUOX1, dual oxidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LNOX1, NOXEF1, THOX1
  • Links
    NCBI Gene ID: 53905
    neXtProt AC: NX_Q9NRD9

  • Chr Location
    15q15.3; chr15:45129992-45165578 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68136
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DUOX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Duox1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015570 VEGA Gene Model | MGI Sequence Detail 32301 C57BL/6J ±  kb
transcript OTTMUST00000036997 VEGA | MGI Sequence Detail 5267 Not Applicable  
polypeptide OTTMUSP00000016602 VEGA | MGI Sequence Detail 1551 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    293 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 20
    Primer pair 3
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:208740 Gorissen SH, et al., Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury. Am J Respir Cell Mol Biol. 2013 Mar;48(3):337-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory