Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DTX3L
  • Mouse genes Dtx3l
  • Rat genes Dtx3l
  • Zfish genes dtx3lb.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dtx3l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	DTX3L	IPI	UniProtKB:Q8IXQ6	Human	PMID:28525742
Molecular Function	GO:0004857	enzyme inhibitor activity	DTX3L	IMP		Human	PMID:24790097
Molecular Function	GO:0042393	histone binding	DTX3L	IDA		Human	PMID:19818714
Molecular Function	GO:0042393	histone binding	DTX3L	IPI	UniProtKB:Q93079	Human	PMID:26479788
Molecular Function	GO:0140852	histone ubiquitin ligase activity	DTX3L	IMP		Human	PMID:26479788
Molecular Function	GO:0140768	protein ADP-ribosyltransferase-substrate adaptor activity	DTX3L	IDA		Human	PMID:28525742
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:Q8IXQ6	Human	PMID:16809771
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:Q8IXQ6	Human	PMID:23230272
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:O14964	Human	PMID:24790097
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:O14964,UniProtKB:Q92783,UniProtKB:Q96J02	Human	PMID:24790097
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:Q92783	Human	PMID:24790097
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:Q9NZD8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:P42224,UniProtKB:Q8IXQ6	Human	PMID:26479788
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:P42224,UniProtKB:Q8IXQ6,UniProtKB:Q93079	Human	PMID:26479788
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DTX3L	IPI	UniProtKB:P61086	Human	PMID:32814053
Molecular Function	GO:0097677	STAT family protein binding	DTX3L	IPI	UniProtKB:P42224	Human	PMID:26479788
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	DTX3L	IPI	UniProtKB:Q96J02	Human	PMID:24790097
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTX3L	IDA		Human	PMID:19818714
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTX3L	IMP		Human	PMID:23230272
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTX3L	IMP		Human	PMID:24790097
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTX3L	IDA		Human	PMID:28525742
Cellular Component	GO:0005737	cytoplasm	DTX3L	IDA		Human	PMID:16809771
Cellular Component	GO:0005737	cytoplasm	DTX3L	IDA		Human	PMID:24790097
Cellular Component	GO:0005737	cytoplasm	DTX3L	IDA		Human	PMID:26479788
Cellular Component	GO:0005829	cytosol	DTX3L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005769	early endosome	DTX3L	IDA		Human	PMID:24790097
Cellular Component	GO:0005764	lysosome	DTX3L	IDA		Human	PMID:24790097
Cellular Component	GO:0005654	nucleoplasm	DTX3L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DTX3L	IDA		Human	PMID:26479788
Cellular Component	GO:0005634	nucleus	DTX3L	IDA		Human	PMID:16809771
Cellular Component	GO:0032991	protein-containing complex	DTX3L	IDA		Human	PMID:24790097
Cellular Component	GO:0032991	protein-containing complex	DTX3L	IDA		Human	PMID:26479788
Biological Process	GO:0000077	DNA damage checkpoint signaling	DTX3L	IMP		Human	PMID:28525742
Biological Process	GO:0006974	DNA damage response	DTX3L	IMP		Human	PMID:19818714
Biological Process	GO:0006302	double-strand break repair	DTX3L	IMP		Human	PMID:23230272
Biological Process	GO:0008333	endosome to lysosome transport	DTX3L	IMP		Human	PMID:24790097
Biological Process	GO:0010390	histone monoubiquitination	DTX3L	IDA		Human	PMID:19818714
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	DTX3L	IMP		Human	PMID:24790097
Biological Process	GO:0035563	positive regulation of chromatin binding	DTX3L	IGI	UniProtKB:Q8IXQ6	Human	PMID:26479788
Biological Process	GO:0002230	positive regulation of defense response to virus by host	DTX3L	IGI	UniProtKB:P42224,UniProtKB:Q8IXQ6	Human	PMID:26479788
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	DTX3L	IGI	UniProtKB:P42224,UniProtKB:Q8IXQ6	Human	PMID:26479788
Biological Process	GO:0032092	positive regulation of protein binding	DTX3L	IMP		Human	PMID:26479788
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	DTX3L	IMP		Human	PMID:24790097
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	DTX3L	IGI	UniProtKB:Q8IXQ6	Human	PMID:26479788
Biological Process	GO:2000646	positive regulation of receptor catabolic process	DTX3L	IMP		Human	PMID:24790097
Biological Process	GO:0051865	protein autoubiquitination	DTX3L	IMP		Human	PMID:24790097
Biological Process	GO:0070936	protein K48-linked ubiquitination	DTX3L	IDA		Human	PMID:26479788
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	DTX3L	IMP		Human	PMID:26479788

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern