Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DMTN
  • Mouse genes Dmtn
  • Rat genes Dmtn
  • Zfish genes dmtn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dmtn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	DMTN	IDA		Human	PMID:22927433
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:P11166	Human	PMID:18347014
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:P27987	Human	PMID:23060452
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:Q8IYF3-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DMTN	IPI	UniProtKB:Q8TAP6	Human	PMID:32296183
Molecular Function	GO:0043621	protein self-association	Dmtn	IDA		Mouse	MGI:MGI:2179688|PMID:12011427
Molecular Function	GO:0005102	signaling receptor binding	DMTN	IDA		Human	PMID:18347014
Molecular Function	GO:0030507	spectrin binding	DMTN	IDA		Human	PMID:22927433
Cellular Component	GO:0005884	actin filament	DMTN	IDA		Human	PMID:22927433
Cellular Component	GO:0031253	cell projection membrane	Dmtn	IDA		Mouse	MGI:MGI:3803395|PMID:18505823
Cellular Component	GO:0030863	cortical cytoskeleton	Dmtn	IDA		Mouse	PMID:18723693
Cellular Component	GO:0031410	cytoplasmic vesicle	DMTN	IDA		Human	PMID:18347014
Cellular Component	GO:0005829	cytosol	DMTN	IDA		Human	PMID:23060452
Cellular Component	GO:0005829	cytosol	Dmtn	IDA		Mouse	MGI:MGI:3803395|PMID:18505823
Cellular Component	GO:0016020	membrane	Dmtn	IDA		Mouse	PMID:18723693
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Dmtn	IDA		Mouse	MGI:MGI:3803395|PMID:18505823
Cellular Component	GO:0005886	plasma membrane	DMTN	IDA		Human	PMID:23060452
Cellular Component	GO:0031095	platelet dense tubular network membrane	DMTN	IDA		Human	PMID:23060452
Cellular Component	GO:0014069	postsynaptic density	Dmtn	IDA		Mouse	PMID:17114649
Cellular Component	GO:0014731	spectrin-associated cytoskeleton	DMTN	IDA		Human	PMID:22927433
Biological Process	GO:0030036	actin cytoskeleton organization	Dmtn	IMP		Mouse	MGI:MGI:2179688|PMID:12011427
Biological Process	GO:0090527	actin filament reorganization	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0035585	calcium-mediated signaling using extracellular calcium source	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0071277	cellular response to calcium ion	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0071320	cellular response to cAMP	DMTN	IDA		Human	PMID:22927433
Biological Process	GO:0048821	erythrocyte development	Dmtn	IMP		Mouse	MGI:MGI:2179688|PMID:12011427
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0090315	negative regulation of protein targeting to membrane	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0030194	positive regulation of blood coagulation	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0010763	positive regulation of fibroblast migration	Dmtn	IDA		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:1901731	positive regulation of platelet aggregation	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0090303	positive regulation of wound healing	Dmtn	IMP		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0070560	protein secretion by platelet	Dmtn	IMP		Mouse	MGI:MGI:5465511|PMID:23060452
Biological Process	GO:0065003	protein-containing complex assembly	DMTN	IDA		Human	PMID:18347014
Biological Process	GO:0065003	protein-containing complex assembly	Dmtn	IDA		Mouse	MGI:MGI:2179688|PMID:12011427
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	DMTN	IDA		Human	PMID:22927433
Biological Process	GO:0008360	regulation of cell shape	DMTN	IMP		Human	PMID:10565303
Biological Process	GO:0008360	regulation of cell shape	Dmtn	IMP		Mouse	MGI:MGI:2179688|PMID:12011427
Biological Process	GO:0008360	regulation of cell shape	Dmtn	IDA		Mouse	MGI:MGI:3803395|PMID:18505823
Biological Process	GO:0051489	regulation of filopodium assembly	DMTN	IMP		Human	PMID:10565303
Biological Process	GO:0010591	regulation of lamellipodium assembly	DMTN	IMP		Human	PMID:10565303

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern