Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLG5
  • Mouse genes Dlg5
  • Rat genes Dlg5
  • Zfish genes dlg5a,dlg5b.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlg5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	DLG5	IDA		Human	PMID:12657639
Molecular Function	GO:0008092	cytoskeletal protein binding	DLG5	IDA		Human	PMID:12657639
Molecular Function	GO:0005515	protein binding	DLG5	IPI	UniProtKB:Q62312	Human	PMID:23624079
Molecular Function	GO:0005515	protein binding	DLG5	IPI	UniProtKB:Q64729	Human	PMID:23624079
Molecular Function	GO:0005515	protein binding	DLG5	IPI	UniProtKB:P27448|UniProtKB:Q13043|UniProtKB:Q13188	Human	PMID:28087714
Molecular Function	GO:0005515	protein binding	DLG5	IPI	UniProtKB:Q14160	Human	PMID:28169360
Molecular Function	GO:0005515	protein binding	Dlg5	IPI	UniProtKB:B7ZNG0|UniProtKB:P56726	Mouse	MGI:MGI:5617062|PMID:25644602
Molecular Function	GO:0005515	protein binding	Dlg5	IPI	UniProtKB:Q03141|UniProtKB:Q9JI10|UniProtKB:Q9JI11	Mouse	MGI:MGI:5823491|PMID:28087714
Molecular Function	GO:0005515	protein binding	Dlg5	IPI	UniProtKB:Q02248	Mouse	MGI:MGI:5608921|PMID:25232112
Molecular Function	GO:0005515	protein binding	Dlg5	IPI	PR:P70452	Mouse	PMID:17765678
Cellular Component	GO:0005912	adherens junction	Dlg5	IDA		Mouse	PMID:17765678
Cellular Component	GO:0005912	adherens junction	Dlg5	IDA		Mouse	PMID:12657639
Cellular Component	GO:0030054	cell junction	DLG5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030054	cell junction	DLG5	IDA		Human	PMID:28169360
Cellular Component	GO:0036064	ciliary basal body	Dlg5	IDA		Mouse	MGI:MGI:5617062|PMID:25644602
Cellular Component	GO:0098978	glutamatergic synapse	Dlg5	IDA		Mouse	PMID:25232112
Cellular Component	GO:0098978	glutamatergic synapse	Dlg5	IEP		Mouse	PMID:25232112
Cellular Component	GO:0098978	glutamatergic synapse	Dlg5	IMP		Mouse	PMID:25232112
Cellular Component	GO:0014069	postsynaptic density	Dlg5	IDA		Mouse	PMID:25232112
Cellular Component	GO:0014069	postsynaptic density	Dlg5	IEP		Mouse	PMID:25232112
Biological Process	GO:0045176	apical protein localization	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:23466739
Biological Process	GO:0001837	epithelial to mesenchymal transition	DLG5	IMP		Human	PMID:28169360
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:23466739
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:23466739
Biological Process	GO:0030011	maintenance of cell polarity	DLG5	IMP		Human	PMID:28169360
Biological Process	GO:0072205	metanephric collecting duct development	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0030901	midbrain development	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0030336	negative regulation of cell migration	DLG5	IMP		Human	PMID:28169360
Biological Process	GO:0035331	negative regulation of hippo signaling	DLG5	IMP		Human	PMID:28087714
Biological Process	GO:0035331	negative regulation of hippo signaling	Dlg5	IMP		Mouse	MGI:MGI:5823491|PMID:28087714
Biological Process	GO:0042130	negative regulation of T cell proliferation	DLG5	IMP		Human	PMID:28169360
Biological Process	GO:0060563	neuroepithelial cell differentiation	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0030859	polarized epithelial cell differentiation	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0060999	positive regulation of dendritic spine development	Dlg5	IMP		Mouse	MGI:MGI:5608921|PMID:25232112
Biological Process	GO:0035332	positive regulation of hippo signaling	DLG5	IMP		Human	PMID:28169360
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Dlg5	IMP		Mouse	MGI:MGI:5617062|PMID:25644602
Biological Process	GO:0051965	positive regulation of synapse assembly	Dlg5	IMP		Mouse	MGI:MGI:5608921|PMID:25232112
Biological Process	GO:0099173	postsynapse organization	Dlg5	IDA		Mouse	PMID:25232112
Biological Process	GO:0099173	postsynapse organization	Dlg5	IMP		Mouse	PMID:25232112
Biological Process	GO:0071896	protein localization to adherens junction	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0065003	protein-containing complex assembly	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678
Biological Process	GO:0045186	zonula adherens assembly	Dlg5	IMP	MGI:MGI:3757646	Mouse	PMID:17765678

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern