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Dlg5
Gene Detail
 Symbol
Name
ID
Dlg5
discs, large homolog 5 (Drosophila)
MGI:1918478
Synonyms 4933429D20Rik, mKIAA0583
Feature Type protein coding gene
Genetic Map
Chromosome 14
14.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:24133953-24245920 bp, - strand
From VEGA annotation of GRCm38

  111968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlg5

Human
homologs
Human Homolog DLG5, discs, large homolog 5 (Drosophila)
NCBI Gene ID 9231
neXtProt AC  NX_Q8TDM6
Human Synonyms  LP-DLG, PDLG, P-DLG5
Human Chr (Location)  10q23; chr10:77790791-77926590 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit growth retardation, hydroencephaly, abnormal brain morphology, abnormal neurogenesis, kidney cysts, ureter defects, and abnormal kidney morphology.
 
Interactions
Dlg5 interacts with 211 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apical protein localization, epithelial tube branching involved in lung morphogenesis, ...
Component cell-cell adherens junction
Function beta-catenin binding, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) cDNA(108)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000036719 (Evidence)
Ensembl Gene ModelENSMUSG00000021782 (Evidence)
Entrez Gene71228 (Evidence)
UniGene68971
DFCITC1577401, TC1587091, TC1597029, TC1618694
DoTSDT.101400980, DT.110779257, DT.486878, DT.91306905, DT.94255829
NIA Mouse Gene IndexU035307
Consensus CDS ProjectCCDS49416.1, CCDS49417.1
International Mouse Knockout Project StatusDlg5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036719 VEGA Gene Model | MGI Sequence Detail 111968 C57BL/6J ±  kb
transcript OTTMUST00000094102 VEGA | MGI Sequence Detail 7851 Not Applicable 
polypeptide OTTMUSP00000052282 VEGA | MGI Sequence Detail 1921 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(16) UniProt(11)
Polymorphisms SNPs within 2kb(303 from dbSNP Build 137)    SNPs within 2kb including multiple locations(307)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR006907 Domain of unknown function DUF622
InterPro IPR008144 Guanylate kinase
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006515 disks large homolog 5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196288 Nechiporuk T, et al., Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84
All references(34)
Other
accession IDs
MGI:2145886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory