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Dlg5 Gene Detail
Summary
  • Symbol
    Dlg5
  • Name
    discs, large homolog 5 (Drosophila)
  • Synonyms
    4933429D20Rik, mKIAA0583
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918478
    NCBI Gene: 71228
  • Gene Overview
    MyGene.info: DLG5
Location & Maps
more
  • Sequence Map
    Chr14:24133953-24245920 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      111968 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 14.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DLG5, discs large MAGUK scaffold protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLG5, discs large MAGUK scaffold protein 5
    Orthology source: HomoloGene
  • Synonyms
    LP-DLG, PDLG, P-DLG5
  • Links
    NCBI Gene ID: 9231
    neXtProt AC: NX_Q8TDM6

  • Chr Location
    10q23; chr10:77790787-77926590 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3486
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DLG5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Gene trapped
    18
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a null allele exhibit growth retardation, hydroencephaly, abnormal brain morphology, abnormal neurogenesis, kidney cysts, ureter defects, and abnormal kidney morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036719 VEGA Gene Model | MGI Sequence Detail 111968 C57BL/6J ±  kb
transcript OTTMUST00000094102 VEGA | MGI Sequence Detail 7851 Not Applicable  
polypeptide OTTMUSP00000052282 VEGA | MGI Sequence Detail 1921 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    301 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 108
    cDNA 108

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145886
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232418 Yu H, et al., A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis. J Clin Invest. 2016 Mar 1;126(3):1067-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory