Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DKK2
  • Mouse genes Dkk2
  • Rat genes Dkk2
  • Zfish genes dkk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dkk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0039706	co-receptor binding	Dkk2	IPI	UniProtKB:O75581	Mouse	MGI:MGI:5700314|PMID:11357136
Molecular Function	GO:0005515	protein binding	DKK2	IPI	UniProtKB:P60371	Human	PMID:32296183
Cellular Component	GO:0005615	extracellular space	DKK2	IDA		Human	PMID:11742004
Biological Process	GO:0001889	liver development	dkk2	IMP	ZFIN:ZDB-MRPHLNO-130430-1	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	dkk2	IGI	ZFIN:ZDB-GENE-040426-2209	Zfish	PMID:23484855
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK2	IDA		Human	PMID:11742004
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk2	IDA		Mouse	MGI:MGI:5700314|PMID:11357136
Biological Process	GO:0048884	neuromast development	dkk2	IMP	ZFIN:ZDB-GENO-140121-6	Zfish	PMID:23891113
Biological Process	GO:0048884	neuromast development	dkk2	IMP	ZFIN:ZDB-GENO-140121-9	Zfish	PMID:23891113
Biological Process	GO:0048884	neuromast development	dkk2	IMP	ZFIN:ZDB-MRPHLNO-131119-9	Zfish	PMID:23891113
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	DKK2	IDA		Human	PMID:12857724

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern