About   Help   FAQ
Dkk2
Gene Detail
Symbol

Name
ID
Dkk2
dickkopf homolog 2 (Xenopus laevis)
MGI:1890663
Feature Type
protein coding gene
Genetic Map
Chromosome 3
61.32 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:132085292-132180293 bp, + strand
From Ensembl annotation of GRCm38

  95002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DKK2
Protein SuperFamily: Dickkopf-related protein Dkk-1/Dkk-2
Gene Tree: Dkk2

Human
homologs
DKK2, dickkopf WNT signaling pathway inhibitor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27123
neXtProt AC: NX_Q9UBU2

Human Synonyms: DKK-2

Human Chr (Location): 4q25; chr4:106921802-107036296 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from APF , CvDC )
 
mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture.
 
Interactions
Dkk2 interacts with 312 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (36 records)
Data Summary: Results (324)    Tissues (275)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 288
RT-PCR 34
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DKK2 ZFIN dkk2    NEW 
Molecular
reagents
All nucleic(33) cDNA(23) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000028031 (Evidence)
Entrez Gene 56811 (Evidence)
UniGene 103593
DFCI TC1582753
DoTS DT.101725968
NIA Mouse Gene Index U003863
PDB 2JTK
Consensus CDS Project CCDS17844.1
International Mouse Phenotyping Consortium Status Dkk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028031 Ensembl Gene Model | MGI Sequence Detail 95002 C57BL/6J ±  kb
transcript ENSMUST00000029665 Ensembl | MGI Sequence Detail 3694 Not Applicable 
polypeptide ENSMUSP00000029665 Ensembl | MGI Sequence Detail 259 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(605 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006796 Dickkopf, N-terminal cysteine-rich
Protein Ontology PR:000006500 dickkopf-related protein 2
References
(Earliest) J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
(Latest) J:216214 Raspopovic J, et al., Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science. 2014 Aug 1;345(6196):566-70
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory