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Dkk2
Gene Detail
 Symbol
Name
ID
Dkk2
dickkopf homolog 2 (Xenopus laevis)
MGI:1890663
Feature Type protein coding gene
Genetic Map
Chromosome 3
61.32 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:132085292-132180293 bp, + strand
From Ensembl annotation of GRCm38

  95002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Dickkopf-related protein Dkk-1/Dkk-2
Gene Tree: Dkk2

Human
homologs
Human Homolog DKK2, dickkopf WNT signaling pathway inhibitor 2
NCBI Gene ID 27123
neXtProt AC  NX_Q9UBU2
Human Synonyms  DKK-2
Human Chr (Location)  4q25; chr4:106921802-107036296 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from APF )
 
mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture.
 
Interactions
Dkk2 interacts with 313 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process multicellular organismal development, negative regulation of canonical Wnt signaling pathway, ...
Component extracellular region, extracellular space
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (324)    Tissues (275)    Images (62)
Theiler Stages: 1, 2, 3, 4, 8, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 288
RT-PCR 34
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(23) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000028031 (Evidence)
Entrez Gene56811 (Evidence)
UniGene103593
DFCITC1582753
DoTSDT.101725968
NIA Mouse Gene IndexU003863
PDB2JTK
Consensus CDS ProjectCCDS17844.1
International Mouse Knockout Project StatusDkk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028031 Ensembl Gene Model | MGI Sequence Detail 95002 C57BL/6J ±  kb
transcript ENSMUST00000029665 Ensembl | MGI Sequence Detail 3694 Not Applicable 
polypeptide ENSMUSP00000029665 Ensembl | MGI Sequence Detail 259 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(605 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006796 Dickkopf, N-terminal cysteine-rich
Protein Ontology PR:000006500 dickkopf-related protein 2
References (Earliest) J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
(Latest) J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All references(65)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory