Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DGCR8
  • Mouse genes Dgcr8
  • Rat genes Dgcr8
  • Zfish genes dgcr8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dgcr8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	DGCR8	IDA		Human	PMID:17704815
Molecular Function	GO:0020037	heme binding	DGCR8	IDA		Human	PMID:24449907
Molecular Function	GO:0020037	heme binding	DGCR8	IDA		Human	PMID:24910438
Molecular Function	GO:0042802	identical protein binding	DGCR8	IPI	UniProtKB:Q8WYQ5	Human	PMID:15574589
Molecular Function	GO:0042802	identical protein binding	DGCR8	IPI	UniProtKB:Q8WYQ5	Human	PMID:17159994
Molecular Function	GO:0070878	primary miRNA binding	DGCR8	IDA		Human	PMID:24910438
Molecular Function	GO:0070878	primary miRNA binding	Dgcr8	IDA		Mouse	PMID:28819115
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:15574589
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:19626115
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:22222205
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:22796965
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q96SB4	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:23995758
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:24581491
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:P22626	Human	PMID:26321680
Molecular Function	GO:0005515	protein binding	DGCR8	IPI	UniProtKB:Q9NRR4	Human	PMID:26496610
Molecular Function	GO:0042803	protein homodimerization activity	DGCR8	IDA		Human	PMID:15574589
Molecular Function	GO:0140517	protein-RNA adaptor activity	DGCR8	IDA		Human	PMID:15574589
Cellular Component	GO:0005737	cytoplasm	DGCR8	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005829	cytosol	DGCR8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098978	glutamatergic synapse	Dgcr8	IEP		Mouse	PMID:22897173
Cellular Component	GO:0098978	glutamatergic synapse	Dgcr8	IDA		Mouse	PMID:22897173
Cellular Component	GO:0098978	glutamatergic synapse	Dgcr8	IPI		Mouse	PMID:22897173
Cellular Component	GO:0070877	microprocessor complex	DGCR8	IDA		Human	PMID:15574589
Cellular Component	GO:0016604	nuclear body	DGCR8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DGCR8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DGCR8	IDA		Human	PMID:15574589
Cellular Component	GO:0014069	postsynaptic density	Dgcr8	IDA		Mouse	PMID:22897173
Cellular Component	GO:0014069	postsynaptic density	Dgcr8	IPI		Mouse	PMID:22897173
Cellular Component	GO:0014069	postsynaptic density	Dgcr8	IEP		Mouse	PMID:22897173
Biological Process	GO:2000633	positive regulation of pre-miRNA processing	DGCR8	IDA		Human	PMID:15574589
Biological Process	GO:2000633	positive regulation of pre-miRNA processing	DGCR8	IDA		Human	PMID:32926445
Biological Process	GO:0031053	primary miRNA processing	DGCR8	IDA		Human	PMID:15531877
Biological Process	GO:0031053	primary miRNA processing	DGCR8	IDA		Human	PMID:15574589
Biological Process	GO:0031053	primary miRNA processing	DGCR8	IDA		Human	PMID:24449907
Biological Process	GO:0031053	primary miRNA processing	DGCR8	IDA		Human	PMID:24910438
Biological Process	GO:0072091	regulation of stem cell proliferation	Dgcr8	IMP	MGI:MGI:3819698	Mouse	PMID:21609717

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern