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Dgcr8
Gene Detail
Symbol

Name
ID
Dgcr8
DiGeorge syndrome critical region gene 8
MGI:2151114
Synonyms
D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.31 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr16:18253948-18289249 bp, - strand
From VEGA annotation of GRCm38

  35302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dgcr8

Human
homologs
Human Homolog DGCR8, DGCR8 microprocessor complex subunit
NCBI Gene ID 54487
neXtProt AC  NX_Q8WYQ5
Human Synonyms  C22orf12, DGCRK6, Gy1, pasha
Human Chr (Location)  22q11.2; chr22:20080232-20111877 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DGCR8
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Gene trapped(81) Targeted(7)
Genomic Mutations involving Dgcr8 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homnozygous mice are embryonic lethal.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Dgcr8 interacts with 245 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process primary miRNA processing, regulation of stem cell proliferation
Component cytoplasm, microtubule cytoskeleton, ...
Function double-stranded RNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (106)    Tissues (55)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
Northern blot 3
RT-PCR 68
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(15) cDNA(15) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023707 (Evidence)
Ensembl Gene ModelENSMUSG00000022718 (Evidence)
Entrez Gene94223 (Evidence)
NIA Mouse Gene IndexU036858, U052943
Consensus CDS ProjectCCDS28018.1
International Mouse Knockout Project StatusDgcr8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023707 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
transcript OTTMUST00000057892 VEGA | MGI Sequence Detail 4320 Not Applicable 
polypeptide OTTMUSP00000027994 VEGA | MGI Sequence Detail 773 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(38) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(70 from dbSNP Build 137)    SNPs within 2kb including multiple locations(72)
Protein-related
information
ResourceIDDescription
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR001202 WW domain
Protein Ontology PR:000006441 microprocessor complex subunit DGCR8
References
(Earliest) J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
(Latest) J:211625 Chun S, et al., Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models. Science. 2014 Jun 6;344(6188):1178-82
All references(81)
Other
accession IDs
MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory