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Dgcr8 Gene Detail
Summary
  • Symbol
    Dgcr8
  • Name
    DiGeorge syndrome critical region gene 8
  • Synonyms
    D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151114
    NCBI Gene: 94223
  • Gene Overview
    MyGene.info: DGCR8
Location & Maps
more
  • Sequence Map
    Chr16:18253948-18289249 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35302 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.31 cM, cytoband B1
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    DGCR8, DGCR8, microprocessor complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGCR8, DGCR8, microprocessor complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C22orf12, DGCRK6, Gy1, pasha
  • Links
    NCBI Gene ID: 54487
    neXtProt AC: NX_Q8WYQ5

  • Chr Location
    22q11.2; chr22:20080232-20111877 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11223
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DGCR8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DGCR8 associations

Human Disease Mouse Models
       Velocardiofacial Syndrome   OMIM: 192430
Click on a disease name to see all genes associated with that disease.

  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 7 genetic backgrounds
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    93
  • Gene trapped
    81
  • Targeted
    12
  • Genomic Mutations
    9 involving Dgcr8
  • Incidental Mutations
Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homnozygous mice are embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023707 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
transcript OTTMUST00000057892 VEGA | MGI Sequence Detail 4320 Not Applicable  
polypeptide OTTMUSP00000027994 VEGA | MGI Sequence Detail 773 Not Applicable  
For the selected sequence
Polymorphisms
less
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006441 microprocessor complex subunit DGCR8
  • InterPro Domains
    IPR014720 Double-stranded RNA-binding domain
    IPR001202 WW domain
Molecular
Reagents
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  • All nucleic 34
    Genomic 15
    cDNA 15
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900
References
more
  • Summaries
    All 89
    Developmental Gene Expression 11
    Diseases 12
    Gene Ontology 4
    Phenotypes 78
  • Earliest
    J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
  • Latest
    J:232835 Modzelewski AJ, et al., Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. J Cell Sci. 2015 Jun 15;128(12):2314-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory