Dgcr8
Gene Detail

Symbol Name ID

Dgcr8 DiGeorge syndrome critical region gene 8 MGI:2151114

Synonyms

D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.31 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr16:18253948-18289249 bp, - strand From VEGA annotation of GRCm38   35302 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dgcr8

Human homologs

Human Homolog		DGCR8, DiGeorge syndrome critical region gene 8
NCBI Gene ID		54487
neXtProt AC		NX_Q8WYQ5
Human Synonyms		C22orf12, DGCRK6, Gy1, pasha
Human Chr (Location)		22q11.2; chr22:20067755-20099400 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DGCR8

Alleles and phenotypes

All alleles(84) : Targeted(3) Gene trapped(81)
 

Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homnozygous mice are embryonic lethal.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	primary miRNA processing
Component	cytoplasm, microtubule cytoskeleton, ...
Function	double-stranded RNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (106)    Tissues (54)    Images (13)
Theiler Stages: 2, 3, 15, 16, 17, 19, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	35
Northern blot	3
RT-PCR	68

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(15) cDNA(15) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023707 (Evidence)
Ensembl Gene Model	ENSMUSG00000022718 (Evidence)
Entrez Gene	94223 (Evidence)
NIA Mouse Gene Index	U036858, U052943
Consensus CDS Project	CCDS28018.1
International Mouse Knockout Project Status	Dgcr8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023707	VEGA Gene Model | MGI Sequence Detail	35302	C57BL/6J
transcript	OTTMUST00000057892	VEGA | MGI Sequence Detail	4320	Not Applicable
polypeptide	OTTMUSP00000027994	VEGA | MGI Sequence Detail	773	Not Applicable

All sequences(47) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(66 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001159	Double-stranded RNA-binding
InterPro	IPR014720	Double-stranded RNA-binding-like
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000006441	microprocessor complex subunit DGCR8

References

(Earliest) J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
(Latest) J:193500 Xu B, et al., Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell. 2013 Jan 17;152(1-2):262-75
All references(71)

Other accession IDs

MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900