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Dgcr8 Gene Detail
Summary
  • Symbol
    Dgcr8
  • Name
    DGCR8, microprocessor complex subunit
  • Synonyms
    D16H22S1742E, D16H22S788E, D16Wis2, DiGeorge syndrome critical region gene 8, Gy1, N41, Vo59c07
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151114
    NCBI Gene: 94223
  • Gene Overview
    MyGene.info: DGCR8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:18253948-18289249 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35302 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.31 cM, cytoband B1
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    DGCR8, DGCR8, microprocessor complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGCR8, DGCR8, microprocessor complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C22orf12, DGCRK6, Gy1, pasha
  • Links
    NCBI Gene ID: 54487
    neXtProt AC: NX_Q8WYQ5
    UniProt: Q8WYQ5

  • Chr Location
    22q11.21; chr22:20080232-20111877 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11223
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGCR8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DGCR8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 7 genetic backgrounds
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homozygous mice are embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023707 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
    transcript OTTMUST00000057892 VEGA | MGI Sequence Detail 4320 Not Applicable  
    polypeptide OTTMUSP00000027994 VEGA | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 15
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 12
      Diseases 5
      Gene Ontology 5
      Phenotypes 98
    • Earliest
      J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
    • Latest
      J:259678 Zou Y, et al., Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation. Sci Rep. 2018 Jan 23;8(1):1468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory