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Dgcr8
Gene Detail
Symbol

Name
ID
Dgcr8
DiGeorge syndrome critical region gene 8
MGI:2151114
Synonyms
D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.31 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr16:18253948-18289249 bp, - strand
From VEGA annotation of GRCm38

  35302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DGCR8
Gene Tree: Dgcr8

Human
homologs
DGCR8, DGCR8 microprocessor complex subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54487
neXtProt AC: NX_Q8WYQ5

Human Synonyms: C22orf12, DGCRK6, Gy1, pasha

Human Chr (Location): 22q11.2; chr22:20080232-20111877 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DGCR8

Mutations,
alleles, and
phenotypes
All mutations/alleles(93) : Gene trapped(81) Targeted(12)
Genomic Mutations involving Dgcr8 (9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homnozygous mice are embryonic lethal.
 
Mutations Annotated to Human Diseases (3)   
Interactions
Dgcr8 interacts with 245 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process primary miRNA processing, regulation of stem cell proliferation, ...
Component cytoplasm, microprocessor complex, ...
Function double-stranded RNA binding, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (106)    Tissues (55)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
Northern blot 3
RT-PCR 68
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dgcr8 ; ZFIN dgcr8    NEW 
Molecular
reagents
All nucleic(34) Genomic(15) cDNA(15) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023707 (Evidence)
Ensembl Gene Model ENSMUSG00000022718 (Evidence)
Entrez Gene 94223 (Evidence)
NIA Mouse Gene Index U036858, U052943
Consensus CDS Project CCDS28018.1
International Mouse Phenotyping Consortium Status Dgcr8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023707 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
transcript OTTMUST00000057892 VEGA | MGI Sequence Detail 4320 Not Applicable 
polypeptide OTTMUSP00000027994 VEGA | MGI Sequence Detail 773 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(26) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(70 from dbSNP Build 137)    SNPs within 2kb including multiple locations(72)
Protein-related
information
ResourceIDDescription
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR001202 WW domain
Protein Ontology PR:000006441 microprocessor complex subunit DGCR8
References
(Earliest) J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
(Latest) J:219570 Cao Y, et al., miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO J. 2015 Mar 4;34(5):609-23
All references(82)
Other
accession IDs
MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory