Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DES
  • Mouse genes Des
  • Rat genes Des
  • Zfish genes desma,desmb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Des

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008092	cytoskeletal protein binding	DES	IPI	UniProtKB:Q04020	Human	PMID:11309420
Molecular Function	GO:0042802	identical protein binding	DES	IPI	UniProtKB:P17661	Human	PMID:21135508
Molecular Function	GO:0042802	identical protein binding	DES	IPI	UniProtKB:P17661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O15061	Human	PMID:11353857
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P58107	Human	PMID:16923132
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P40692	Human	PMID:20706999
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q13496	Human	PMID:21135508
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P20929	Human	PMID:23615443
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q15149	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q08426	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q6NYC8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q7KZS0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O43812	Human	PMID:26816005
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q9UBX2	Human	PMID:26816005
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P07196	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P07196	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P08670	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O76041	Human	PMID:27733623
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P02511	Human	PMID:28470624
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P08670	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O60437	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O75928-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O76014	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:O95678	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P07196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P07947	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P08670	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P13646	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P14136	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P19012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P26196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P35900	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P41219	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P52954	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P61968	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P62487	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q14525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q2TBE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q496Y0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q6NYC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q8TAB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q8TC57	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q8WUE5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q8WWB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q96BZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q9HC98-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q9UBB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q9UJ78-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q9UL15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P41219	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DES	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q9Z2C5	Mouse	MGI:MGI:5000185|PMID:21135508
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q9UBX2	Mouse	MGI:MGI:5770010|PMID:26816005
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q13496	Mouse	MGI:MGI:5000185|PMID:21135508
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q8K0L0-1	Mouse	MGI:MGI:6102779|PMID:26343497
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q9QXS1	Mouse	MGI:MGI:7260090|PMID:24940650
Molecular Function	GO:0005515	protein binding	Des	IPI	UniProtKB:Q8C4J4	Mouse	PMID:11694502
Cellular Component	GO:0097512	cardiac myofibril	DES	IDA		Human	PMID:25771144
Cellular Component	GO:0005911	cell-cell junction	Des	IDA		Mouse	PMID:24532688
Cellular Component	GO:0043292	contractile fiber	Des	IDA		Mouse	PMID:14627610
Cellular Component	GO:0005737	cytoplasm	Des	IDA		Mouse	MGI:MGI:5752078|PMID:26787680
Cellular Component	GO:0005737	cytoplasm	Des	IDA		Mouse	PMID:21177767
Cellular Component	GO:0005856	cytoskeleton	Des	IDA		Mouse	PMID:11694502
Cellular Component	GO:0070062	extracellular exosome	DES	HDA		Human	PMID:23533145
Cellular Component	GO:0005916	fascia adherens	Des	IDA		Mouse	PMID:11732910
Cellular Component	GO:0005921	gap junction	Des	IDA		Rat	PMID:17673670|RGD:6784510
Cellular Component	GO:0014704	intercalated disc	DES	IDA		Human	PMID:24200904
Cellular Component	GO:0014704	intercalated disc	DES	IDA		Human	PMID:26724190
Cellular Component	GO:0005882	intermediate filament	Des	IDA		Mouse	MGI:MGI:3723417|PMID:16917092
Cellular Component	GO:0045111	intermediate filament cytoskeleton	DES	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031594	neuromuscular junction	Des	IDA		Mouse	PMID:11694502
Cellular Component	GO:0005634	nucleus	Des	IDA		Mouse	MGI:MGI:5752078|PMID:26787680
Cellular Component	GO:0042383	sarcolemma	DES	IDA		Human	PMID:25394388
Cellular Component	GO:0042383	sarcolemma	Des	IDA		Mouse	MGI:MGI:5621256|PMID:25394388
Cellular Component	GO:0042383	sarcolemma	Des	IDA		Mouse	PMID:11694502
Cellular Component	GO:0045098	type III intermediate filament	Des	IDA		Rat	PMID:12529857|RGD:1580288
Cellular Component	GO:0030018	Z disc	DES	IDA		Human	PMID:24200904
Cellular Component	GO:0030018	Z disc	DES	IDA		Human	PMID:26724190
Cellular Component	GO:0030018	Z disc	DES	IDA		Human	PMID:9415431
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	MGI:MGI:5752078|PMID:26787680
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	PMID:14627610
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	PMID:10532952
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	PMID:32878913
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	PMID:15138196
Cellular Component	GO:0030018	Z disc	Des	IDA		Mouse	PMID:11694502
Cellular Component	GO:0030018	Z disc	Des	IDA		Rat	PMID:23615443|RGD:13210543
Cellular Component	GO:0030018	Z disc	desma	IDA		Zfish	PMID:25866181
Biological Process	GO:0060047	heart contraction	desma	IMP	ZFIN:ZDB-MRPHLNO-100114-8	Zfish	PMID:19800866
Biological Process	GO:0045109	intermediate filament organization	DES	IMP		Human	PMID:24200904
Biological Process	GO:0045109	intermediate filament organization	DES	IMP		Human	PMID:26724190
Biological Process	GO:0007626	locomotory behavior	desmb	IMP	ZFIN:ZDB-MRPHLNO-150622-1	Zfish	PMID:25866181
Biological Process	GO:0007626	locomotory behavior	desma	IMP	ZFIN:ZDB-MRPHLNO-100114-9	Zfish	PMID:25866181
Biological Process	GO:0006936	muscle contraction	desmb	IGI	ZFIN:ZDB-MRPHLNO-130619-4,ZFIN:ZDB-MRPHLNO-130619-6	Zfish	PMID:23440276
Biological Process	GO:0006936	muscle contraction	desma	IGI	ZFIN:ZDB-MRPHLNO-130619-4,ZFIN:ZDB-MRPHLNO-130619-6	Zfish	PMID:23440276
Biological Process	GO:0030239	myofibril assembly	desma	IMP	ZFIN:ZDB-MRPHLNO-100114-9	Zfish	PMID:25866181
Biological Process	GO:0010522	regulation of calcium ion transport into cytosol	desma	IMP	ZFIN:ZDB-GENO-220705-1	Zfish	PMID:33820917
Biological Process	GO:0055117	regulation of cardiac muscle contraction	desma	IMP	ZFIN:ZDB-GENO-170501-2	Zfish	PMID:26051936
Biological Process	GO:0055117	regulation of cardiac muscle contraction	desma	IMP	ZFIN:ZDB-GENO-170501-7	Zfish	PMID:26051936
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	desma	IMP	ZFIN:ZDB-GENO-170501-7	Zfish	PMID:26051936
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	desma	IMP	ZFIN:ZDB-GENO-170501-2	Zfish	PMID:26051936
Biological Process	GO:0045214	sarcomere organization	desma	IMP	ZFIN:ZDB-MRPHLNO-100114-8	Zfish	PMID:19800866
Biological Process	GO:0060538	skeletal muscle organ development	desmb	IGI	ZFIN:ZDB-MRPHLNO-130619-3,ZFIN:ZDB-MRPHLNO-130619-5	Zfish	PMID:23440276
Biological Process	GO:0060538	skeletal muscle organ development	desmb	IGI	ZFIN:ZDB-MRPHLNO-130619-4,ZFIN:ZDB-MRPHLNO-130619-6	Zfish	PMID:23440276
Biological Process	GO:0060538	skeletal muscle organ development	desma	IGI	ZFIN:ZDB-MRPHLNO-130619-3,ZFIN:ZDB-MRPHLNO-130619-5	Zfish	PMID:23440276
Biological Process	GO:0060538	skeletal muscle organ development	desma	IGI	ZFIN:ZDB-MRPHLNO-130619-4,ZFIN:ZDB-MRPHLNO-130619-6	Zfish	PMID:23440276
Biological Process	GO:0007519	skeletal muscle tissue development	desma	IMP	ZFIN:ZDB-MRPHLNO-100114-9	Zfish	PMID:25866181

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern