Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDX1
  • Mouse genes Ddx1
  • Rat genes Ddx1
  • Zfish genes ddx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	DDX1	IDA		Human	PMID:19058135
Molecular Function	GO:0033677	DNA/RNA helicase activity	DDX1	IDA		Human	PMID:18710941
Molecular Function	GO:0003725	double-stranded RNA binding	Ddx1	IDA		Mouse	PMID:21703541
Molecular Function	GO:0004518	nuclease activity	DDX1	IDA		Human	PMID:18710941
Molecular Function	GO:0008143	poly(A) binding	DDX1	IDA		Human	PMID:12183465
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:P33240	Human	PMID:11598190
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:P61978	Human	PMID:12183465
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q9NR56	Human	PMID:18335541
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q13315	Human	PMID:18710941
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q04206	Human	PMID:19058135
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:P0C6Y1:PRO_0000037415	Human	PMID:20573827
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q9Y224	Human	PMID:24608264
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q8NCA5	Human	PMID:28040436
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q8NCA5	Human	PMID:29992460
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:Q9Y224	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:P0DTC9	Human	PMID:34232536
Molecular Function	GO:0005515	protein binding	DDX1	IPI	UniProtKB:P0DTC9	Human	PMID:35107372
Molecular Function	GO:0005515	protein binding	Ddx1	IPI	UniProtKB:P83870	Mouse	MGI:MGI:4839441|PMID:18758164
Molecular Function	GO:0005515	protein binding	Ddx1	IPI	PR:Q9JIK5	Mouse	PMID:21703541
Molecular Function	GO:0003723	RNA binding	DDX1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	DDX1	HDA		Human	PMID:22681889
Molecular Function	GO:0003724	RNA helicase activity	DDX1	IDA		Human	PMID:12183465
Molecular Function	GO:0003724	RNA helicase activity	DDX1	IDA		Human	PMID:18710941
Molecular Function	GO:0003712	transcription coregulator activity	DDX1	IDA		Human	PMID:19058135
Cellular Component	GO:0071920	cleavage body	DDX1	IDA		Human	PMID:11598190
Cellular Component	GO:0005737	cytoplasm	DDX1	IDA		Human	PMID:24608264
Cellular Component	GO:0005737	cytoplasm	DDX1	IDA		Human	PMID:24965446
Cellular Component	GO:0010494	cytoplasmic stress granule	DDX1	IDA		Human	PMID:18335541
Cellular Component	GO:0010494	cytoplasmic stress granule	Ddx1	IDA		Mouse	PMID:21933836
Cellular Component	GO:0005829	cytosol	DDX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ddx1	IDA		Mouse	MGI:MGI:5050760|PMID:21703541
Cellular Component	GO:0016020	membrane	DDX1	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Ddx1	IDA		Mouse	MGI:MGI:5050760|PMID:21703541
Cellular Component	GO:0005654	nucleoplasm	DDX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DDX1	IDA		Human	PMID:19058135
Cellular Component	GO:0005634	nucleus	DDX1	IDA		Human	PMID:24608264
Cellular Component	GO:1990904	ribonucleoprotein complex	DDX1	IDA		Human	PMID:18809582
Cellular Component	GO:0072669	tRNA-splicing ligase complex	DDX1	IDA		Human	PMID:21311021
Cellular Component	GO:0072669	tRNA-splicing ligase complex	DDX1	IDA		Human	PMID:24870230
Biological Process	GO:0032508	DNA duplex unwinding	DDX1	IDA		Human	PMID:18710941
Biological Process	GO:0006302	double-strand break repair	DDX1	IDA		Human	PMID:18710941
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	DDX1	IDA		Human	PMID:18710941
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ddx1	IMP		Mouse	MGI:MGI:5050760|PMID:21703541
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	Ddx1	IMP		Mouse	MGI:MGI:5050760|PMID:21703541
Biological Process	GO:1903608	protein localization to cytoplasmic stress granule	DDX1	IMP		Human	PMID:24965446
Biological Process	GO:0043330	response to exogenous dsRNA	Ddx1	IMP		Mouse	PMID:21703541
Biological Process	GO:0009615	response to virus	Ddx1	IMP		Mouse	PMID:21703541
Biological Process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	DDX1	IMP		Human	PMID:24870230

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern