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Term Detail
GO term:transcription cofactor activity
Synonym: transcriptional cofactor activity
Synonym: transcriptional co-regulator
Synonym: transcription cofactor activity
GO id:GO:0003712
Definition:Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-atranscription factor activity, protein binding
                        is-atranscription factor activity, transcription factor binding
                                is-aanti-sigma factor antagonist activity
                                is-asigma factor antagonist activity
                                is-atranscription cofactor activity [GO:0003712] (429 genes, 649 annotations)
                                        is-aRNA polymerase II transcription cofactor activity +
                                        is-atranscription coactivator activity +
                                        is-atranscription corepressor activity +
                                is-atranscription factor activity, RNA polymerase I transcription factor binding +
                                is-atranscription factor activity, RNA polymerase II transcription factor binding +
                                is-atranscription factor activity, RNA polymerase III transcription factor binding +
                                is-atranscription factor activity, transcription factor recruiting +

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory