Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dcc

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DCC
- Mouse genes Dcc
- Rat genes Dcc
- Zfish genes dcc
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dcc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Dcc	IPI	UniProtKB:Q63155	Rat	PMID:18585357\|RGD:8553710
Molecular Function	GO:0005042	netrin receptor activity	Dcc	IMP		Rat	PMID:8861902\|RGD:729062
Molecular Function	GO:0038006	netrin receptor activity involved in chemoattraction	dcc	IGI	ZFIN:ZDB-GENO-100622-2,ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:19605629
Molecular Function	GO:0038006	netrin receptor activity involved in chemoattraction	dcc	IGI	ZFIN:ZDB-GENO-100622-2,ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:19605629
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P56270	Human	PMID:11527412
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:Q9UKG1	Human	PMID:12011067
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P55211	Human	PMID:16537496
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:Q9ERC8	Human	PMID:18585357
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:O95631	Human	PMID:19721007
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P55211	Human	PMID:19721007
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:O95631	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P46777	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P46779	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:P62266	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:Q9HD67	Human	PMID:21642953
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:Q9C026	Human	PMID:22084112
Molecular Function	GO:0005515	protein binding	DCC	IPI	UniProtKB:O95631	Human	PMID:26190107
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:Q9ERC8	Mouse	MGI:MGI:3829111\|PMID:18585357
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:Q8BME9	Mouse	MGI:MGI:6271505\|PMID:29782851
Molecular Function	GO:0005515	protein binding	Dcc	IPI	MGI:MGI:1338823	Mouse	PMID:11527412
Molecular Function	GO:0005515	protein binding	Dcc	IPI	RGD:3250	Rat	PMID:15788770\|RGD:2314386
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:Q8CGU4	Rat	PMID:18469807\|RGD:8553892
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:Q9ERC8	Rat	PMID:18585357\|RGD:8553710
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:P46777	Rat	PMID:20434207\|RGD:8553836
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:P63086	Rat	PMID:21070949\|RGD:13432290
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:O55005	Rat	PMID:21215373\|RGD:8554092
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:Q9HD67	Rat	PMID:21321230\|RGD:13432304
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:P15311	Rat	PMID:21849478\|RGD:14402440
Molecular Function	GO:0005515	protein binding	Dcc	IPI	UniProtKB:P31977	Rat	PMID:21849478\|RGD:14402440
Molecular Function	GO:0003713	transcription coactivator activity	Dcc	IMP		Rat	PMID:12840034\|RGD:1298870
Cellular Component	GO:0030424	axon	Dcc	IDA		Mouse	PMID:9331350
Cellular Component	GO:0030424	axon	Dcc	IDA		Rat	PMID:12840034\|RGD:1298870
Cellular Component	GO:0030424	axon	Dcc	IDA		Rat	PMID:22473424\|RGD:10411906
Cellular Component	GO:0032584	growth cone membrane	Dcc	IDA		Rat	PMID:18691385\|RGD:2314356
Cellular Component	GO:0045121	membrane raft	Dcc	IDA		Rat	PMID:15811950\|RGD:2314384
Cellular Component	GO:0098839	postsynaptic density membrane	Dcc	IDA		Mouse	PMID:23291093
Cellular Component	GO:0098839	postsynaptic density membrane	Dcc	IEP		Mouse	PMID:23291093
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Dcc	IDA		Mouse	PMID:23291093
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Dcc	IEP		Mouse	PMID:23291093
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Dcc	IMP		Mouse	PMID:23291093
Biological Process	GO:0021960	anterior commissure morphogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-2	Zfish	PMID:22956848
Biological Process	GO:0021960	anterior commissure morphogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:22956848
Biological Process	GO:0021960	anterior commissure morphogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22956848
Biological Process	GO:0033564	anterior/posterior axon guidance	Dcc	IMP		Mouse	PMID:18479186
Biological Process	GO:0033564	anterior/posterior axon guidance	dcc	IGI	ZFIN:ZDB-GENO-100622-2,ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:19605629
Biological Process	GO:0033564	anterior/posterior axon guidance	dcc	IGI	ZFIN:ZDB-GENO-100622-2,ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:19605629
Biological Process	GO:0061564	axon development	Dcc	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0048846	axon extension involved in axon guidance	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:27955617
Biological Process	GO:0048846	axon extension involved in axon guidance	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:21828101
Biological Process	GO:0007411	axon guidance	Dcc	IMP		Rat	PMID:8861902\|RGD:729062
Biological Process	GO:0007411	axon guidance	dcc	IMP	ZFIN:ZDB-GENO-150211-18	Zfish	PMID:25355219
Biological Process	GO:0031103	axon regeneration	dcc	IMP	ZFIN:ZDB-GENO-150211-18	Zfish	PMID:25355219
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-2	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:22956848
Biological Process	GO:0021987	cerebral cortex development	Dcc	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0071679	commissural neuron axon guidance	dcc	IMP	ZFIN:ZDB-GENO-200421-3	Zfish	PMID:24553931
Biological Process	GO:0022038	corpus callosum development	Dcc	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0016358	dendrite development	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-2	Zfish	PMID:17182783
Biological Process	GO:0016358	dendrite development	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:17182783
Biological Process	GO:0016358	dendrite development	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:17182783
Biological Process	GO:0033563	dorsal/ventral axon guidance	Dcc	IMP	MGI:MGI:1934924	Mouse	PMID:17898206
Biological Process	GO:0048665	neuron fate specification	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22003409
Biological Process	GO:0001764	neuron migration	Dcc	IMP	MGI:MGI:1934924	Mouse	PMID:16267219
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IMP	ZFIN:ZDB-GENO-130612-4	Zfish	PMID:26732841
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IGI	ZFIN:ZDB-GENE-030519-2	Zfish	PMID:26732841
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IMP	ZFIN:ZDB-MRPHLNO-070330-1	Zfish	PMID:22457493
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22457493
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IMP	ZFIN:ZDB-GENO-130612-4	Zfish	PMID:22457493
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IGI	ZFIN:ZDB-MRPHLNO-060810-1,ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22457493
Biological Process	GO:0071678	olfactory bulb axon guidance	dcc	IGI	ZFIN:ZDB-MRPHLNO-070328-5,ZFIN:ZDB-MRPHLNO-070328-6	Zfish	PMID:22457493
Biological Process	GO:0021554	optic nerve development	Dcc	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Dcc	IMP		Rat	PMID:15811950\|RGD:2314384
Biological Process	GO:0010976	positive regulation of neuron projection development	Dcc	IMP		Rat	PMID:15737744\|RGD:2314389
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Dcc	IMP		Mouse	PMID:23291093
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Dcc	IDA		Mouse	PMID:23291093
Biological Process	GO:0030516	regulation of axon extension	dcc	IMP	ZFIN:ZDB-MRPHLNO-070328-5	Zfish	PMID:22606267
Biological Process	GO:0030516	regulation of axon extension	dcc	IGI	ZFIN:ZDB-MRPHLNO-070328-5,ZFIN:ZDB-MRPHLNO-070328-6,ZFIN:ZDB-MRPHLNO-120604-2	Zfish	PMID:22606267
Biological Process	GO:1901214	regulation of neuron death	DCC	IMP		Human	PMID:21085126
Biological Process	GO:0001975	response to amphetamine	Dcc	IEP		Rat	PMID:17996376\|RGD:2314370
Biological Process	GO:0021965	spinal cord ventral commissure morphogenesis	Dcc	IMP	MGI:MGI:1934924	Mouse	PMID:9126737

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.