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Dcc Gene Detail
Summary
  • Symbol
    Dcc
  • Name
    deleted in colorectal carcinoma
  • Synonyms
    C030036D22Rik, Igdcc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94869
    NCBI Gene: 13176
  • Gene Overview
    MyGene.info: DCC
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:71253634-72351069 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 45.24 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7221 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94869
 protein coding gene Chr18:71253613-72351228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024546
 protein coding gene Chr18:71740652-72906838 (-)
A/J MGP_AJ_G0024513
 protein coding gene Chr18:68632227-69741609 (-)
AKR/J MGP_AKRJ_G0024484
 protein coding gene Chr18:70649165-71767849 (-)
BALB/cJ MGP_BALBcJ_G0024513
 protein coding gene Chr18:68783384-69894819 (-)
C3H/HeJ MGP_C3HHeJ_G0024281
 protein coding gene Chr18:70737500-71896745 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024959
 protein coding gene Chr18:73642822-74847684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022390
 protein coding gene Chr18:67823694-68900008 (-)
CAST/EiJ MGP_CASTEiJ_G0023754
 protein coding gene Chr18:70863375-72043175 (-)
CBA/J MGP_CBAJ_G0024250
 protein coding gene Chr18:76136785-77395879 (-)
DBA/2J MGP_DBA2J_G0024380
 protein coding gene Chr18:68229714-69325013 (-)
FVB/NJ MGP_FVBNJ_G0024346
 protein coding gene Chr18:67596240-68679134 (-)
LP/J MGP_LPJ_G0024464
 protein coding gene Chr18:71610036-72775503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024376
 protein coding gene Chr18:77437733-78839722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025007
 protein coding gene Chr18:70793787-71944390 (-)
PWK/PhJ MGP_PWKPhJ_G0023498
 protein coding gene Chr18:68591812-69708076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023302
 protein coding gene Chr18:70905559-72058251 (-)
WSB/EiJ MGP_WSBEiJ_G0023817
 protein coding gene Chr18:70729074-71867845 (-)



Homology
more
  • Human Ortholog
    DCC, DCC netrin 1 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DCC, DCC netrin 1 receptor
    Orthology source: HomoloGene
  • Synonyms
    CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
  • Links
    NCBI Gene ID: 1630
    neXtProt AC: NX_P43146
    UniProt: P43146

  • Chr Location
    18q21.2; chr18:52340172-53535903 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 21081
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DCC
  • Gene Tree
    Dcc
Human Diseases
more
  • Diseases
    2 with human DCC associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 8 genetic backgrounds
    30 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1114
  • Tissues
    173
  • cDNA Data
    37
  • Literature Summary
    145
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060534 Ensembl Gene Model | MGI Sequence Detail 1097436 C57BL/6J ±  kb
    transcript ENSMUST00000114943 Ensembl | MGI Sequence Detail 10323 Not Applicable  
    polypeptide ENSMUSP00000110593 Ensembl | MGI Sequence Detail 1447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 2
      cDNA 40
      Primer pair 9
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-8808, MGI:1924857
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 145
      Diseases 1
      Gene Ontology 13
      Phenotypes 87
    • Earliest
      J:15303 Fearon ER, et al., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5;247(4938):49-56
    • Latest
      J:299984 Gao R, et al., Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. J Clin Invest. 2021 Jan 4;131(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/04/2021
    MGI 6.16     		The Jackson Laboratory