Dcc MGI Mouse Gene Detail - MGI:94869 - deleted in colorectal carcinoma

Symbol

Dcc
Name

deleted in colorectal carcinoma
Synonyms

C030036D22Rik, Igdcc1

Feature Type

protein coding gene
IDs

MGI:94869
NCBI Gene: 13176
Gene Overview

MyGene.info: DCC
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr18:71258738-72351069 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 45.24 cM
Mapping Data

13 experiments

SNPs within 2kb

7215 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94869	protein coding gene	Chr18:71253613-72351240 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024546	protein coding gene	Chr18:71740652-72906838 (-)
A/J	MGP_AJ_G0024513	protein coding gene	Chr18:68632227-69741609 (-)
AKR/J	MGP_AKRJ_G0024484	protein coding gene	Chr18:70649165-71767849 (-)
BALB/cJ	MGP_BALBcJ_G0024513	protein coding gene	Chr18:68783384-69894819 (-)
C3H/HeJ	MGP_C3HHeJ_G0024281	protein coding gene	Chr18:70737500-71896745 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024959	protein coding gene	Chr18:73642822-74847684 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022390	protein coding gene	Chr18:67823694-68900008 (-)
CAST/EiJ	MGP_CASTEiJ_G0023754	protein coding gene	Chr18:70863375-72043175 (-)
CBA/J	MGP_CBAJ_G0024250	protein coding gene	Chr18:76136785-77395879 (-)
DBA/2J	MGP_DBA2J_G0024380	protein coding gene	Chr18:68229714-69325013 (-)
FVB/NJ	MGP_FVBNJ_G0024346	protein coding gene	Chr18:67596240-68679134 (-)
LP/J	MGP_LPJ_G0024464	protein coding gene	Chr18:71610036-72775503 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024376	protein coding gene	Chr18:77437733-78839722 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025007	protein coding gene	Chr18:70793787-71944390 (-)
PWK/PhJ	MGP_PWKPhJ_G0023498	protein coding gene	Chr18:68591812-69708076 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023302	protein coding gene	Chr18:70905559-72058251 (-)
WSB/EiJ	MGP_WSBEiJ_G0023817	protein coding gene	Chr18:70729074-71867845 (-)

Human Ortholog

DCC, DCC netrin 1 receptor

Vertebrate Orthologs

9

Human Ortholog

DCC, DCC netrin 1 receptor
Orthology source: HomoloGene
Synonyms

CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Links

HGNC:2701

NCBI Gene ID: 1630

neXtProt AC: NX_P43146

UniProt: P43146
Chr Location

18q21.2; chr18:52340172-53535903 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21081
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DCC
Gene Tree

Dcc

Diseases

2 with human DCC associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 KEGG:05210 MESH:D015179 OMIM:114500 OMIM:608812 OMIM:611469 OMIM:612229 OMIM:612230 OMIM:612231 OMIM:612232 OMIM:612589 OMIM:612590 OMIM:612591 OMIM:612592 OMIM:615083 UMLS_CUI:C1527249
				esophageal cancer IDs esophageal cancer DOID:5041 DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 5 alleles in 8 genetic backgrounds
30 phenotypes from multigenic genotypes
80 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

1
Spontaneous

1
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding.

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All GO Annotations

28
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

458
Tissues

169
cDNA Data

36
Literature Summary

132

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcc

ZFIN dcc

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Dcc interacts with 235 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS29336.1
UniGene

167882

Ensembl

ENSMUSG00000060534 (Evidence)
NCBI Gene

13176

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060534	Ensembl Gene Model \| MGI Sequence Detail	1092332	C57BL/6J	± kb
transcript	ENSMUST00000114943	Ensembl \| MGI Sequence Detail	5219	Not Applicable
polypeptide	ENSMUSP00000110593	Ensembl \| MGI Sequence Detail	1447	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006304 netrin receptor DCC

(term hierarchy)
PDB

3PZD, 4PLO
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR010560 Neogenin, C-terminal

IPR033012 Netrin receptor DCC

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All nucleic 53

Genomic 2

cDNA 39

Primer pair 9

Other 3

Microarray probesets 5

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MGD-MRK-8808, MGI:1924857

Summaries

All 230

Developmental Gene Expression 132

Diseases 1

Gene Ontology 12

Phenotypes 80
Earliest

J:15303 Fearon ER, et al., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5;247(4938):49-56
Latest

J:272917 Moreno-Bravo JA, et al., Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance. Neuron. 2019 Feb 20;101(4):625-634.e3

TSS for Dcc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153873	Chr18:72351137-72351156 (-)	-78 bp
Tssr153872	Chr18:72351090-72351108 (-)	-30 bp
Tssr153871	Chr18:72351076-72351087 (-)	-13 bp
Tssr153870	Chr18:72351029-72351073 (-)	18 bp
Tssr153869	Chr18:72351009-72351022 (-)	53 bp
Tssr153868	Chr18:72350984-72350993 (-)	80 bp
Tssr153867	Chr18:72350791-72350815 (-)	266 bp
Tssr153866	Chr18:72350495-72350567 (-)	538 bp
Tssr153865	Chr18:72350393-72350405 (-)	670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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