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Dcc
Gene Detail
Symbol

Name
ID
Dcc
deleted in colorectal carcinoma
MGI:94869
Synonyms
C030036D22Rik, Igdcc1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
45.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr18:71258738-72351069 bp, - strand
From VEGA annotation of GRCm38

  1092332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Dcc

Human
homologs
Human Homolog DCC, DCC netrin 1 receptor
NCBI Gene ID 1630
neXtProt AC  NX_P43146
Human Synonyms  CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
Human Chr (Location)  18q21.3; chr18:52340172-53535903 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human DCC
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Spontaneous(1) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding.
 
Human Diseases Modeled Using Mouse Dcc (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Dcc interacts with 236 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process anterior/posterior axon guidance, apoptotic process, ...
Component axon, growth cone membrane, ...
Function identical protein binding, netrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (431)    Tissues (157)    Images (98)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 292
Northern blot 6
Western blot 4
RT-PCR 66
RNase protection 36
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(2) cDNA(37) Primer pair(8) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021996 (Evidence)
Ensembl Gene ModelENSMUSG00000060534 (Evidence)
Entrez Gene13176 (Evidence)
UniGene167882
DFCITC1608072, TC1630403, TC1683620
DoTSDT.40164866, DT.60102386, DT.87059042, DT.91576495
NIA Mouse Gene IndexU038545
PDB3PZD, 4PLO
Consensus CDS ProjectCCDS29336.1
International Mouse Knockout Project StatusDcc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021996 VEGA Gene Model | MGI Sequence Detail 1092332 C57BL/6J ±  kb
transcript OTTMUST00000052227 VEGA | MGI Sequence Detail 5219 Not Applicable 
polypeptide OTTMUSP00000024718 VEGA | MGI Sequence Detail 1447 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(7261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR010560 Neogenin, C-terminal
Protein Ontology PR:000006304 netrin receptor DCC
References
(Earliest) J:15303 Fearon ER, et al., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5;247(4938):49-56
(Latest) J:214366 Liang DY, et al., The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration. BMC Genomics. 2014;15:345
All references(163)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-8808, MGI:1924857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory