Dcc
Gene Detail

Symbol Name ID

Dcc deleted in colorectal carcinoma MGI:94869

Synonyms

C030036D22Rik, Igdcc1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

45.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr18:71258738-72351069 bp, - strand From VEGA annotation of GRCm38   1092332 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Dcc

Human homologs

Human Homolog		DCC, deleted in colorectal carcinoma
NCBI Gene ID		1630
neXtProt AC		NX_P43146
Human Synonyms		CRC18, CRCR1, IGDCC1, MRMV1
Human Chr (Location)		18q21.3; chr18:49866542-51062273 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DCC

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(1) Transgenic(1) Spontaneous(1)
 

Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding.

 
Human Diseases Modeled Using Mouse Dcc (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	anterior/posterior axon guidance, apoptotic process, ...
Component	axon, growth cone membrane, ...
Function	identical protein binding, netrin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (88 records)
Data Summary: Results (431)    Tissues (156)    Images (98)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	292
Northern blot	6
Western blot	4
RT-PCR	66
RNase protection	36

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(2) cDNA(37) Primer pair(8) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021996 (Evidence)
Ensembl Gene Model	ENSMUSG00000060534 (Evidence)
Entrez Gene	13176 (Evidence)
UniGene	167882
DFCI	TC1608072, TC1630403, TC1683620
DoTS	DT.40164866, DT.60102386, DT.87059042, DT.91576495
NIA Mouse Gene Index	U038545
PDB	3PZD
Consensus CDS Project	CCDS29336.1
International Mouse Knockout Project Status	Dcc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021996	VEGA Gene Model | MGI Sequence Detail	1092332	C57BL/6J
transcript	OTTMUST00000052227	VEGA | MGI Sequence Detail	5219	Not Applicable
polypeptide	OTTMUSP00000024718	VEGA | MGI Sequence Detail	1447	Not Applicable

All sequences(37) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs within 2kb(7261 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR010560	Neogenin, C-terminal
Protein Ontology	PR:000006304	netrin receptor DCC

References

(Earliest) J:15303 Fearon ER, et al., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5;247(4938):49-56
(Latest) J:197638 van den Berghe V, et al., Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron. 2013 Jan 9;77(1):70-82
All references(155)

Other accession IDs

MGD-MRK-8808, MGI:1924857