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Dcc Gene Detail
Summary
  • Symbol
    Dcc
  • Name
    deleted in colorectal carcinoma
  • Synonyms
    C030036D22Rik, Igdcc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94869
    NCBI Gene: 13176
  • Gene Overview
    MyGene.info: DCC
Location & Maps
more
  • Sequence Map
    Chr18:71258738-72351069 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1092332 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 45.24 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    DCC, DCC netrin 1 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DCC, DCC netrin 1 receptor
    Orthology source: HomoloGene
  • Synonyms
    CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
  • Links
    NCBI Gene ID: 1630
    neXtProt AC: NX_P43146

  • Chr Location
    18q21.3; chr18:52340172-53535903 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21081
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DCC
  • Gene Tree
    Dcc
Human Diseases
more
  • Diseases
    3 with human DCC associations

Human Disease Mouse Models
       Colorectal Cancer; CRC   OMIM: 114500
Esophageal Cancer   OMIM: 133239
Mirror Movements 1; MRMV1   OMIM: 157600
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021996 VEGA Gene Model | MGI Sequence Detail 1092332 C57BL/6J ±  kb
transcript OTTMUST00000052227 VEGA | MGI Sequence Detail 5219 Not Applicable  
polypeptide OTTMUSP00000024718 VEGA | MGI Sequence Detail 1447 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7215 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    Genomic 2
    cDNA 38
    Primer pair 8
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-8808, MGI:1924857
References
more
  • Summaries
    All 186
    Developmental Gene Expression 110
    Diseases 1
    Gene Ontology 11
    Phenotypes 58
  • Earliest
    J:15303 Fearon ER, et al., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5;247(4938):49-56
  • Latest
    J:228865 Law C, et al., Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory