Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYLD
  • Mouse genes Cyld
  • Rat genes Cyld
  • Zfish genes cylda
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyld

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	CYLD	IDA		Human	PMID:18313383
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	CYLD	IDA		Human	PMID:18636086
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	CYLD	IDA		Human	PMID:27458237
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	CYLD	IDA		Human	PMID:27591049
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Cyld	IDA		Mouse	MGI:MGI:5912943|PMID:28701375
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	Cyld	IDA		Mouse	PMID:16501569
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	CYLD	IDA		Human	PMID:18313383
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	CYLD	EXP		Human	PMID:26997266
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	CYLD	IDA		Human	PMID:26997266
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	CYLD	IDA		Human	PMID:29291351
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	Cyld	IDA		Mouse	MGI:MGI:6706628|PMID:32424362
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	Cyld	IDA		Mouse	MGI:MGI:6162308|PMID:29291351
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	Cyld	IDA		Mouse	PMID:16501569
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	cylda	IDA		Zfish	PMID:25686088
Molecular Function	GO:0061815	Met1-linked polyubiquitin deubiquitinase activity	CYLD	EXP		Human	PMID:26997266
Molecular Function	GO:0070064	proline-rich region binding	CYLD	IPI	UniProtKB:Q9Y6K9	Human	PMID:15341735
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:O95786	Human	PMID:18636086
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q7Z434	Human	PMID:18636086
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q71U36	Human	PMID:19893491
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UBN7	Human	PMID:19893491
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q92997	Human	PMID:20227366
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q96J02	Human	PMID:22057290
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q96J02-2	Human	PMID:22057290
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q5VT06	Human	PMID:25134987
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q96EP0	Human	PMID:26997266
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:27307491
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:27458237
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:27545878
Molecular Function	GO:0005515	protein binding	CYLD	IPI	UniProtKB:Q9UM82	Human	PMID:27591049
Molecular Function	GO:0005515	protein binding	Cyld	IPI	UniProtKB:Q9Z2V5	Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0005515	protein binding	Cyld	IPI	UniProtKB:Q8C863	Mouse	MGI:MGI:5300860|PMID:22057290
Molecular Function	GO:0005515	protein binding	Cyld	IPI	UniProtKB:P68369|UniProtKB:Q9Z2V5	Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0005515	protein binding	Cyld	IPI	UniProtKB:Q9Z2F6	Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0005515	protein binding	Cyld	IPI	UniProtKB:Q9Z2F6	Mouse	MGI:MGI:3624874|PMID:16713561
Molecular Function	GO:0005515	protein binding	Cyld	IPI	PR:P06240	Mouse	PMID:16501569
Molecular Function	GO:0019901	protein kinase binding	CYLD	IPI	UniProtKB:P53350	Human	PMID:17495026
Molecular Function	GO:0019901	protein kinase binding	CYLD	IPI	UniProtKB:Q14164	Human	PMID:18636086
Molecular Function	GO:0019901	protein kinase binding	CYLD	IPI	UniProtKB:Q9UHD2	Human	PMID:18636086
Molecular Function	GO:0008270	zinc ion binding	CYLD	IDA		Human	PMID:18313383
Cellular Component	GO:0005813	centrosome	CYLD	IDA		Human	PMID:25134987
Cellular Component	GO:0036064	ciliary basal body	Cyld	IDA		Mouse	MGI:MGI:5607344|PMID:25134987
Cellular Component	GO:0097542	ciliary tip	Cyld	IDA		Mouse	MGI:MGI:5607344|PMID:25134987
Cellular Component	GO:0005881	cytoplasmic microtubule	CYLD	IDA		Human	PMID:17495026
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	CYLD	IDA		Human	PMID:20194890
Cellular Component	GO:0005829	cytosol	CYLD	IDA		Human	PMID:18313383
Cellular Component	GO:0030496	midbody	CYLD	IDA		Human	PMID:17495026
Cellular Component	GO:0005819	spindle	CYLD	IDA		Human	PMID:25134987
Biological Process	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	Cyld	IMP	MGI:MGI:3664438	Mouse	PMID:16501569
Biological Process	GO:0021551	central nervous system morphogenesis	cylda	IMP	ZFIN:ZDB-MRPHLNO-100215-1	Zfish	PMID:20040115
Biological Process	GO:1904888	cranial skeletal system development	cylda	IMP	ZFIN:ZDB-MRPHLNO-100215-1	Zfish	PMID:28450118
Biological Process	GO:0048872	homeostasis of number of cells	Cyld	IMP	MGI:MGI:3664438	Mouse	PMID:16501569
Biological Process	GO:0045087	innate immune response	CYLD	IDA		Human	PMID:26997266
Biological Process	GO:0070266	necroptotic process	Cyld	IMP		Mouse	PMID:27545878
Biological Process	GO:0070266	necroptotic process	Cyld	IGI	MGI:MGI:2154952	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Cyld	IGI	MGI:MGI:104798	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Cyld	IGI	MGI:MGI:1261423	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Cyld	IGI	MGI:MGI:108212	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Cyld	IGI	MGI:MGI:104798	Mouse	PMID:21052097
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	CYLD	IMP		Human	PMID:20227366
Biological Process	GO:0050728	negative regulation of inflammatory response	Cyld	IMP		Mouse	MGI:MGI:6706628|PMID:32424362
Biological Process	GO:2000493	negative regulation of interleukin-18-mediated signaling pathway	Cyld	IMP		Mouse	MGI:MGI:6706628|PMID:32424362
Biological Process	GO:0046329	negative regulation of JNK cascade	CYLD	IDA		Human	PMID:29291351
Biological Process	GO:0046329	negative regulation of JNK cascade	Cyld	IDA		Mouse	MGI:MGI:6162308|PMID:29291351
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CYLD	IDA		Human	PMID:18313383
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	CYLD	IDA		Human	PMID:18313383
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	CYLD	IDA		Human	PMID:29291351
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	Cyld	IDA		Mouse	MGI:MGI:6162308|PMID:29291351
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	CYLD	IMP		Human	PMID:21525013
Biological Process	GO:1903829	positive regulation of protein localization	Cyld	IDA		Mouse	PMID:16501569
Biological Process	GO:0045582	positive regulation of T cell differentiation	Cyld	IMP	MGI:MGI:3664438	Mouse	PMID:16501569
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	Cyld	IMP	MGI:MGI:3664438	Mouse	PMID:16501569
Biological Process	GO:0016579	protein deubiquitination	CYLD	IDA		Human	PMID:29291351
Biological Process	GO:0016579	protein deubiquitination	Cyld	IDA		Mouse	MGI:MGI:6162308|PMID:29291351
Biological Process	GO:0016579	protein deubiquitination	Cyld	IMP		Mouse	PMID:22037414
Biological Process	GO:0070536	protein K63-linked deubiquitination	Cyld	IDA		Mouse	MGI:MGI:6162308|PMID:29291351
Biological Process	GO:1990108	protein linear deubiquitination	CYLD	IDA		Human	PMID:26997266
Biological Process	GO:1990108	protein linear deubiquitination	CYLD	IDA		Human	PMID:27458237
Biological Process	GO:1990108	protein linear deubiquitination	CYLD	IDA		Human	PMID:27591049
Biological Process	GO:1990108	protein linear deubiquitination	Cyld	IDA		Mouse	MGI:MGI:5912943|PMID:28701375
Biological Process	GO:1990108	protein linear deubiquitination	cylda	IDA		Zfish	PMID:25686088
Biological Process	GO:0045577	regulation of B cell differentiation	Cyld	IMP	MGI:MGI:3664438	Mouse	PMID:16501569
Biological Process	GO:1902017	regulation of cilium assembly	Cyld	IMP		Mouse	MGI:MGI:5607344|PMID:25134987
Biological Process	GO:0045995	regulation of embryonic development	cylda	IMP	ZFIN:ZDB-GENO-230216-4	Zfish	PMID:33982884
Biological Process	GO:0050727	regulation of inflammatory response	CYLD	IDA		Human	PMID:27591049
Biological Process	GO:2001242	regulation of intrinsic apoptotic signaling pathway	CYLD	IMP		Human	PMID:21525013
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	CYLD	IMP		Human	PMID:20194890
Biological Process	GO:0007346	regulation of mitotic cell cycle	CYLD	IMP		Human	PMID:17495026
Biological Process	GO:0060544	regulation of necroptotic process	CYLD	IDA		Human	PMID:27458237
Biological Process	GO:0060544	regulation of necroptotic process	Cyld	IDA		Mouse	MGI:MGI:5912943|PMID:28701375
Biological Process	GO:0043393	regulation of protein binding	Cyld	IDA		Mouse	PMID:16501569
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	CYLD	IDA		Human	PMID:26997266
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	CYLD	IDA		Human	PMID:27458237
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	CYLD	IDA		Human	PMID:27591049
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Cyld	IDA		Mouse	MGI:MGI:5912943|PMID:28701375
Biological Process	GO:1901026	ripoptosome assembly involved in necroptotic process	Cyld	IMP		Mouse	PMID:22037414

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern