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Cyld
Gene Detail
 Symbol
Name
ID
Cyld
cylindromatosis (turban tumor syndrome)
MGI:1921506
Synonyms 2010013M14Rik, 2900009M21Rik, C130039D01Rik, CYLD1, mKIAA0849
Feature Type protein coding gene
Genetic Map
Chromosome 8
43.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:88697028-88751945 bp, + strand
From NCBI annotation of GRCm38

  54918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cyld

Human
homologs
Human Homolog CYLD, cylindromatosis (turban tumor syndrome)
NCBI Gene ID 1540
neXtProt AC  NX_Q9NQC7
Human Synonyms  BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2
Human Chr (Location)  16q12.1; chr16:50742050-50801936 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CYLD
Alleles
and
phenotypes
All alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Various knockout models with different exon deletions have been created. Observed phenotypes include altered T cell and B cell development, susceptibility to induced skin tumors, resistance to lethal lung infection, high colon tumor incidence, kinky tails, and neonatal death due to lung dysfunction.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process necroptotic process, negative regulation of canonical Wnt signaling pathway, ...
Component centrosome, cytoplasm, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (114)    Tissues (15)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 114
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000036712 (Evidence)
Entrez Gene74256 (Evidence)
DFCITC1575563, TC1593797, TC1604956, TC1605912, TC1606675, TC1627878, TC1653623, TC1714708
DoTSDT.50316473, DT.101154136, DT.101380713, DT.101380714, DT.91429036, DT.91435098, DT.94359794
NIA Mouse Gene IndexU009624
EC3.4.19.12
Consensus CDS ProjectCCDS22513.1, CCDS52633.1
International Mouse Knockout Project StatusCyld
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74256 NCBI Gene Model | MGI Sequence Detail 54918 C57BL/6J ±  kb
transcript NM_001128171 RefSeq | MGI Sequence Detail 8148 C57BL/6 
polypeptide Q80TQ2 UniProt | EBI | MGI Sequence Detail 952 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(27) UniProt(5)
Polymorphisms SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000938 CAP Gly-rich domain
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206660 Yang Y, et al., CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2158-63
All references(64)
Other
accession IDs
MGI:1920125, MGI:2445104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory