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Cyld
Gene Detail
Symbol

Name
ID
Cyld
cylindromatosis (turban tumor syndrome)
MGI:1921506
Synonyms
2010013M14Rik, 2900009M21Rik, C130039D01Rik, CYLD1, mKIAA0849
Feature Type
protein coding gene
Genetic Map
Chromosome 8
43.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:88697028-88751945 bp, + strand
From Ensembl annotation of GRCm38

  54918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYLD
Gene Tree: Cyld

Human
homologs
CYLD, cylindromatosis (turban tumor syndrome)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1540
neXtProt AC: NX_Q9NQC7

Human Synonyms: BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2

Human Chr (Location): 16q12.1; chr16:50742050-50801936 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CYLD

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Various knockout models with different exon deletions have been created. Observed phenotypes include altered T cell and B cell development, susceptibility to induced skin tumors, resistance to lethal lung infection, high colon tumor incidence, kinky tails, and neonatal death due to lung dysfunction.
 
Phenotype Images(1)
Interactions
Cyld interacts with 431 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process necroptotic process, negative regulation of canonical Wnt signaling pathway, ...
Component cell projection, centrosome, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (114)    Tissues (15)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 114
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyld    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000036712 (Evidence)
Entrez Gene 74256 (Evidence)
DFCI TC1593797, TC1575563, TC1606675, TC1627878, TC1604956, TC1605912, TC1714708, TC1653623
DoTS DT.94359794, DT.91435098, DT.91429036, DT.101154136, DT.50316473, DT.101380714, DT.101380713
NIA Mouse Gene Index U009624
EC 3.4.19.12
Consensus CDS Project CCDS22513.1, CCDS52633.1
International Mouse Phenotyping Consortium Status Cyld
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036712 Ensembl Gene Model | MGI Sequence Detail 54918 C57BL/6J ±  kb
transcript ENSMUST00000043526 Ensembl | MGI Sequence Detail 8022 Not Applicable 
polypeptide ENSMUSP00000039834 Ensembl | MGI Sequence Detail 955 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(29) UniProt(5)
Polymorphisms
SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000938 CAP Gly-rich domain
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215909 Eguether T, et al., The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 2014;5:4585
All references(66)
Other
accession IDs
MGI:1920125, MGI:2445104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory