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Cyld Gene Detail
Summary
  • Symbol
    Cyld
  • Name
    CYLD lysine 63 deubiquitinase
  • Synonyms
    2010013M14Rik, 2900009M21Rik, C130039D01Rik, CYLD1, mKIAA0849
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921506
    NCBI Gene: 74256
  • Gene Overview
    MyGene.info: CYLD
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:88697047-88751945 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54899 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 43.51 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CYLD, CYLD lysine 63 deubiquitinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYLD, CYLD lysine 63 deubiquitinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2
  • Links
    NCBI Gene ID: 1540
    neXtProt AC: NX_Q9NQC7
    UniProt: Q9NQC7

  • Chr Location
    16q12.1; chr16:50742026-50801935 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9069
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CYLD
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CYLD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 8 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Various knockout models with different exon deletions have been created. Observed phenotypes include altered T cell and B cell development, susceptibility to induced skin tumors, resistance to lethal lung infection, high colon tumor incidence, kinky tails, and neonatal death due to lung dysfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061528 VEGA Gene Model | MGI Sequence Detail 54899 C57BL/6J ±  kb
    transcript OTTMUST00000150098 VEGA | MGI Sequence Detail 7990 Not Applicable  
    polypeptide OTTMUSP00000077818 VEGA | MGI Sequence Detail 955 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      393 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920125, MGI:2445104
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 1
      Gene Ontology 14
      Phenotypes 70
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:241614 Fernandez-Majada V, et al., The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016 Aug 26;7:12508

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory