Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXCR3
  • Mouse genes Cxcr3
  • Rat genes Cxcr3
  • Zfish genes cxcr3.1,cxcr3.2,cxcr3.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	Cxcr3	IPI	RGD:1316123	Rat	PMID:10825390|RGD:632989
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	Cxcr3	IPI	RGD:1332044	Rat	PMID:10825390|RGD:632989
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	Cxcr3	IPI	RGD:1550709	Rat	PMID:10825390|RGD:632989
Molecular Function	GO:0019956	chemokine binding	CXCR3	IPI	UniProtKB:O43927	Human	PMID:11554781
Molecular Function	GO:0005515	protein binding	CXCR3	IPI	UniProtKB:P61073	Human	PMID:23170857
Molecular Function	GO:0005515	protein binding	CXCR3	IPI	UniProtKB:O14523	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR3	IPI	UniProtKB:Q8N6F1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR3	IPI	UniProtKB:Q9Y6G1	Human	PMID:32296183
Cellular Component	GO:0009986	cell surface	CXCR3	IDA		Human	PMID:20608915
Cellular Component	GO:0009986	cell surface	Cxcr3	IDA		Mouse	PMID:23620790
Cellular Component	GO:0009897	external side of plasma membrane	Cxcr3	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Cxcr3	IDA		Rat	PMID:16434036|RGD:5135509
Cellular Component	GO:0005886	plasma membrane	Cxcr3	IDA		Rat	PMID:10825390|RGD:632989
Biological Process	GO:0019722	calcium-mediated signaling	Cxcr3	IDA		Rat	PMID:10825390|RGD:632989
Biological Process	GO:0007166	cell surface receptor signaling pathway	CXCR3	IDA		Human	PMID:11554781
Biological Process	GO:0070098	chemokine-mediated signaling pathway	cxcr3.2	IGI	ZFIN:ZDB-GENE-060526-78,ZFIN:ZDB-GENO-150616-5	Zfish	PMID:25573892
Biological Process	GO:0070098	chemokine-mediated signaling pathway	cxcr3.2	IGI	ZFIN:ZDB-GENE-070907-2,ZFIN:ZDB-GENO-150616-5	Zfish	PMID:25573892
Biological Process	GO:0002522	leukocyte migration involved in immune response	cxcr3.2	IMP	ZFIN:ZDB-MRPHLNO-101109-2	Zfish	PMID:20424185
Biological Process	GO:0002522	leukocyte migration involved in immune response	cxcr3.2	IMP	ZFIN:ZDB-MRPHLNO-101109-1	Zfish	PMID:20424185
Biological Process	GO:0002281	macrophage activation involved in immune response	cxcr3.2	IMP		Zfish	PMID:25573892
Biological Process	GO:0048246	macrophage chemotaxis	cxcr3.2	IGI	ZFIN:ZDB-GENE-060526-78,ZFIN:ZDB-GENO-150616-5	Zfish	PMID:25573892
Biological Process	GO:0048246	macrophage chemotaxis	cxcr3.2	IGI	ZFIN:ZDB-GENE-070907-2,ZFIN:ZDB-GENO-150616-5	Zfish	PMID:25573892
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Cxcr3	IDA		Rat	PMID:10825390|RGD:632989
Biological Process	GO:0030155	regulation of cell adhesion	CXCR3	IDA		Human	PMID:19703720
Biological Process	GO:0009617	response to bacterium	cxcr3.2	IMP	ZFIN:ZDB-MRPHLNO-101109-2	Zfish	PMID:20424185
Biological Process	GO:0009617	response to bacterium	cxcr3.2	IMP	ZFIN:ZDB-MRPHLNO-101109-1	Zfish	PMID:20424185
Biological Process	GO:0010818	T cell chemotaxis	Cxcr3	IMP		Rat	PMID:21038468|RGD:5135506

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern