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Cxcr3 Gene Detail
Summary
  • Symbol
    Cxcr3
  • Name
    chemokine (C-X-C motif) receptor 3
  • Synonyms
    Cd183, Cmkar3, Cxcr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277207
    NCBI Gene: 12766
  • Gene Overview
    MyGene.info: CXCR3
Location & Maps
more
  • Sequence Map
    ChrX:101731535-101734269 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2735 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 44.58 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
    Orthology source: HomoloGene
  • Synonyms
    CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR, Mig-R
  • Links
    NCBI Gene ID: 2833
    neXtProt AC: NX_P49682

  • Chr Location
    Xq13; chrX:71615914-71618517 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    121 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018202 VEGA Gene Model | MGI Sequence Detail 2735 C57BL/6J ±  kb
transcript OTTMUST00000043946 VEGA | MGI Sequence Detail 1731 Not Applicable  
polypeptide OTTMUSP00000019734 VEGA | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001207 C-X-C chemokine receptor type 3
  • InterPro Domains
    IPR000355 Chemokine receptor family
    IPR004070 CXC chemokine receptor 3
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 158
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 121
  • Earliest
    J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
  • Latest
    J:230433 Brackett CM, et al., Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E874-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory