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Cxcr3 Gene Detail
Summary
  • Symbol
    Cxcr3
  • Name
    chemokine (C-X-C motif) receptor 3
  • Synonyms
    Cd183, Cmkar3, Cxcr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277207
    NCBI Gene: 12766
  • Gene Overview
    MyGene.info: CXCR3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101731535-101734147 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 44.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277207
protein coding gene ChrX:101731535-101734269 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035965
protein coding gene ChrX:98273825-98276556 (-)
A/J MGP_AJ_G0035950
protein coding gene ChrX:98252052-98254786 (-)
AKR/J MGP_AKRJ_G0035866
protein coding gene ChrX:101088820-101091552 (-)
BALB/cJ MGP_BALBcJ_G0035933
protein coding gene ChrX:96998533-97001267 (-)
C3H/HeJ MGP_C3HHeJ_G0035642
protein coding gene ChrX:98672925-98675659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036463
protein coding gene ChrX:101179434-101183026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033292
protein coding gene ChrX:95982071-95984803 (-)
CAST/EiJ MGP_CASTEiJ_G0034929
protein coding gene ChrX:82964718-82967452 (-)
CBA/J MGP_CBAJ_G0035617
protein coding gene ChrX:104320667-104323398 (-)
DBA/2J MGP_DBA2J_G0035771
protein coding gene ChrX:97462151-97465094 (-)
FVB/NJ MGP_FVBNJ_G0035710
protein coding gene ChrX:96846474-96849205 (-)
LP/J MGP_LPJ_G0035862
protein coding gene ChrX:99209455-99212202 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035744
protein coding gene ChrX:108855028-108857762 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036489
protein coding gene ChrX:97943376-97946888 (-)
PWK/PhJ MGP_PWKPhJ_G0034628
protein coding gene ChrX:80567674-80570407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034456
protein coding gene ChrX:83887608-83890339 (-)
WSB/EiJ MGP_WSBEiJ_G0035068
protein coding gene ChrX:96649801-96652534 (-)



Homology
more
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR, Mig-R
  • Links
    NCBI Gene ID: 2833
    neXtProt AC: NX_P49682
    UniProt: P49682

  • Chr Location
    Xq13.1; chrX:71615913-71618517 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    131 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12766 NCBI Gene Model | MGI Sequence Detail 2613 C57BL/6J ±  kb
    transcript NM_009910 RefSeq | MGI Sequence Detail 1609 C57BL/6  
    polypeptide O88410 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 131
    • Earliest
      J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
    • Latest
      J:258124 Caldeira-Dantas S, et al., The Chemokine Receptor CXCR3 Promotes CD8(+) T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection. J Immunol. 2018 Feb 1;200(3):1133-1145

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory