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Cxcr3
Gene Detail
 Symbol
Name
ID
Cxcr3
chemokine (C-X-C motif) receptor 3
MGI:1277207
Synonyms Cd183, Cmkar3, Cxcr3
Feature Type protein coding gene
Genetic Map
Chromosome X
44.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:101731535-101734269 bp, - strand
From VEGA annotation of GRCm38

  2735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr3

Human
homologs
Human Homolog CXCR3, chemokine (C-X-C motif) receptor 3
NCBI Gene ID 2833
neXtProt AC  NX_P49682
Human Synonyms  CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR, Mig-R
Human Chr (Location)  Xq13; chrX:71615916-71618517 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.
 
Interactions
Cxcr3 interacts with 60 markers (Mir32, Mir34a, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process angiogenesis, calcium-mediated signaling, ...
Component cell surface, cytosol, ...
Function chemokine binding, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (89)    Tissues (45)    Images (3)
Theiler Stages: 28
Assay TypeResults
In situ reporter (knock in) 51
RT-PCR 38
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018202 (Evidence)
Ensembl Gene ModelENSMUSG00000050232 (Evidence)
Entrez Gene12766 (Evidence)
UniGene12876
DFCITC1589264
DoTSDT.87048274
NIA Mouse Gene IndexU039582
Consensus CDS ProjectCCDS30319.1
International Mouse Knockout Project StatusCxcr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018202 VEGA Gene Model | MGI Sequence Detail 2735 C57BL/6J ±  kb
transcript OTTMUST00000043946 VEGA | MGI Sequence Detail 1731 Not Applicable 
polypeptide OTTMUSP00000019734 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR004070 CXC chemokine receptor 3
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001207 C-X-C chemokine receptor type 3
References (Earliest) J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
(Latest) J:210856 Villarroel VA, et al., CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease. J Invest Dermatol. 2014 Jun;134(6):1552-60
All references(149)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory