Cxcr3
Gene Detail

Symbol Name ID

Cxcr3 chemokine (C-X-C motif) receptor 3 MGI:1277207

Synonyms

Cd183, Cmkar3, Cxcr3

Feature Type

protein coding gene

Genetic Map

Chromosome X

44.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:101731535-101734269 bp, - strand From VEGA annotation of GRCm38   2735 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cxcr3 ± 2 cM)

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr3

Human ortholog

CXCR3 chemokine (C-X-C motif) receptor 3 NCBI Gene ID 2833
Human Synonyms: CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR, Mig-R
Human ChrX:70835766-70838367 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	calcium-mediated signaling, chemokine-mediated signaling pathway, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	C-C chemokine binding, chemokine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (89)    Tissues (45)    Images (3)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	51
RT-PCR	38

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018202 (Evidence)
Ensembl Gene Model	ENSMUSG00000050232 (Evidence)
Entrez Gene	12766 (Evidence)
UniGene	12876
DFCI	TC1589264
DoTS	DT.87048274
NIA Mouse Gene Index	U039582
Consensus CDS Project	CCDS30319.1
International Mouse Knockout Project Status	Cxcr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018202	VEGA Gene Model | MGI Sequence Detail	2735	C57BL/6J
transcript	OTTMUST00000043946	VEGA | MGI Sequence Detail	1731	Not Applicable
polypeptide	OTTMUSP00000019734	VEGA | MGI Sequence Detail	367	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000355	Chemokine receptor
InterPro	IPR004070	CXC chemokine receptor, type 3
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001207	C-X-C chemokine receptor type 3

References

(Earliest) J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
(Latest) J:192522 Pak-Wittel MA, et al., Interferon-gamma mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E50-9
All references(133)