Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CREM
  • Mouse genes Crem
  • Rat genes Crem
  • Zfish genes crema,cremb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crem

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Crem	IDA		Mouse	PMID:11354513
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	CREM	IMP		Human	PMID:12626549
Molecular Function	GO:0005515	protein binding	CREM	IPI	UniProtKB:Q9Y6K1	Human	PMID:21976679
Molecular Function	GO:0005515	protein binding	Crem	IPI	UniProtKB:O09106	Mouse	MGI:MGI:5616318|PMID:17056544
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Crem	IDA		Mouse	MGI:MGI:5494765|PMID:23443664
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	CREM	IDA		Human	PMID:16899810
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	CREM	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Crem	IDA		Mouse	MGI:MGI:5494765|PMID:23443664
Cellular Component	GO:0005634	nucleus	Crem	IDA		Mouse	PMID:14585816
Cellular Component	GO:0005667	transcription regulator complex	Crem	IDA		Mouse	PMID:11354513
Biological Process	GO:0032922	circadian regulation of gene expression	Crem	IMP		Mouse	MGI:MGI:5494765|PMID:23443664
Biological Process	GO:0007623	circadian rhythm	Crem	IEP		Mouse	MGI:MGI:5494765|PMID:23443664
Biological Process	GO:0006631	fatty acid metabolic process	Crem	IEP		Rat	PMID:14534319|RGD:1582469
Biological Process	GO:0006006	glucose metabolic process	Crem	IEP		Rat	PMID:14534319|RGD:1582469
Biological Process	GO:0006687	glycosphingolipid metabolic process	Crem	IMP	MGI:MGI:2158921	Mouse	PMID:18308723
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Crem	IDA		Mouse	MGI:MGI:5494765|PMID:23443664
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CREM	IMP		Human	PMID:12626549
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Crem	IGI	MGI:MGI:1913192	Mouse	PMID:20488182
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Crem	IGI	MGI:MGI:3056295	Mouse	PMID:20488182
Biological Process	GO:0042752	regulation of circadian rhythm	Crem	IEP		Rat	PMID:15936880|RGD:1582464
Biological Process	GO:0006355	regulation of DNA-templated transcription	CREM	IDA		Human	PMID:8206879
Biological Process	GO:0051591	response to cAMP	Crem	IDA		Mouse	MGI:MGI:5494765|PMID:23443664
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Crem	IEP		Rat	PMID:15725648|RGD:1582466
Biological Process	GO:0007283	spermatogenesis	Crem	IMP	MGI:MGI:2158921	Mouse	PMID:14757819

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern