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Crem
Gene Detail
Symbol

Name
ID
Crem
cAMP responsive element modulator
MGI:88495
Synonyms
ICER
Feature Type
protein coding gene
Genetic Map
Chromosome 18
2.14 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:3266048-3337748 bp, - strand
From VEGA annotation of GRCm38

  71701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84591  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Crem

Human
homologs
Human Homolog CREM, cAMP responsive element modulator
NCBI Gene ID 1390
neXtProt AC  NX_Q03060
Human Synonyms  CREM-2, hCREM-2, ICER
Human Chr (Location)  10p11.21; chr10:35126841-35212958 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(16) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit reduced regenerative capacity after partial hepatectomy and reduced cardiac function. Males are sterile due to a block in spermiogenesis associated with a lack of postmeiotic gene expression.
 
Interactions
Crem interacts with 295 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process circadian regulation of gene expression, glycosphingolipid metabolic process, ...
Component cytoplasm, nucleus, ...
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (175)    Tissues (148)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
RT-PCR 37
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(20) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000033204 (Evidence)
Ensembl Gene ModelENSMUSG00000063889 (Evidence)
Entrez Gene12916 (Evidence)
NIA Mouse Gene IndexU038164, U360581
Consensus CDS ProjectCCDS29031.2, CCDS50209.2, CCDS50210.2, CCDS50211.1, CCDS50212.1, CCDS50213.1, CCDS50214.1, CCDS50215.1, CCDS70862.1, CCDS70863.1, CCDS70864.1
International Mouse Knockout Project StatusCrem
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033204 VEGA Gene Model | MGI Sequence Detail 71701 C57BL/6J ±  kb
transcript OTTMUST00000083129 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000044614 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(303) RefSeq(89) UniProt(31)
Polymorphisms
SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000005866 cAMP-responsive element modulator
References
(Earliest) J:18605 Foulkes NS, et al., CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49
(Latest) J:205444 Verjans E, et al., Overexpression of CREMalpha in T cells aggravates lipopolysaccharide-induced acute lung injury. J Immunol. 2013 Aug 1;191(3):1316-23
All references(100)
Other
accession IDs
MGD-MRK-2137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory