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Crem Gene Detail
Summary
  • Symbol
    Crem
  • Name
    cAMP responsive element modulator
  • Synonyms
    ICER
  • Feature Type
    protein coding gene
  • IDs
    MGI:88495
    NCBI Gene: 12916
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:3266048-3337748 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 2.14 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88495
protein coding gene Chr18:3266048-3338176 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024118
protein coding gene Chr18:46040-124750 (-)
A/J MGP_AJ_G0024080
protein coding gene Chr18:105263-178821 (-)
AKR/J MGP_AKRJ_G0024048
protein coding gene Chr18:107028-180084 (-)
BALB/cJ MGP_BALBcJ_G0024080
protein coding gene Chr18:137994-217073 (-)
C3H/HeJ MGP_C3HHeJ_G0023845
protein coding gene Chr18:61367-145540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024525
protein coding gene Chr18:125069-221551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021964
protein coding gene Chr18:54526-120517 (-)
CAST/EiJ MGP_CASTEiJ_G0023324
protein coding gene Chr18:78533-150762 (-)
CBA/J MGP_CBAJ_G0023819
protein coding gene Chr18:84875-160488 (-)
DBA/2J MGP_DBA2J_G0023947
protein coding gene Chr18:59870-133049 (-)
FVB/NJ MGP_FVBNJ_G0023913
protein coding gene Chr18:63598-141815 (-)
LP/J MGP_LPJ_G0024031
protein coding gene Chr18:87308-171112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023941
protein coding gene Chr18:69167-145014 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024570
protein coding gene Chr18:63387-140924 (-)
PWK/PhJ MGP_PWKPhJ_G0023069
protein coding gene Chr18:108689-182527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022880
protein coding gene Chr18:323403-402498 (-)
WSB/EiJ MGP_WSBEiJ_G0023390
protein coding gene Chr18:64697-139198 (-)



Homology
more
  • Human Ortholog
    CREM, cAMP responsive element modulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CREM, cAMP responsive element modulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREM-2, hCREM-2, ICER
  • Links
    NCBI Gene ID: 1390
    neXtProt AC: NX_Q03060
    UniProt: Q03060

  • Chr Location
    10p11.21; chr10:35126841-35212958 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit reduced regenerative capacity after partial hepatectomy and reduced cardiac function. Males are sterile due to a block in spermiogenesis associated with a lack of postmeiotic gene expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063889 Ensembl Gene Model | MGI Sequence Detail 71701 C57BL/6J ±  kb
    transcript ENSMUST00000150235 Ensembl | MGI Sequence Detail 2662 Not Applicable  
    polypeptide ENSMUSP00000121233 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 21
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-2137
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 22
      Gene Ontology 13
      Phenotypes 48
    • Earliest
      J:18605 Foulkes NS, et al., CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49
    • Latest
      J:265908 Kono M, et al., Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9288-9293

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory