Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cldn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CLDN1
- Mouse genes Cldn1
- Rat genes Cldn1
- Zfish genes cldn1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CLDN1	IPI	UniProtKB:O95832	Human	PMID:25849148
Molecular Function	GO:0042802	identical protein binding	Cldn1	IPI	UniProtKB:O88551	Mouse	MGI:MGI:3513972\|PMID:10562289
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:P60033	Human	PMID:20375010
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q16625	Human	PMID:20375010
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:O00501	Human	PMID:25323998
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:P57739	Human	PMID:25323998
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:O15551	Human	PMID:25849148
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:P16284	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q16625	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q96AP7	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q07108	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q7Z7N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q8TBE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q96HJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN1	IPI	UniProtKB:Q9P0T7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cldn1	IPI	UniProtKB:P39447\|UniProtKB:Q9QXY1\|UniProtKB:Q9Z0U1	Mouse	MGI:MGI:1350677\|PMID:10601346
Molecular Function	GO:0005515	protein binding	Cldn1	IPI	UniProtKB:Q9Z0G9	Mouse	MGI:MGI:3513972\|PMID:10562289
Molecular Function	GO:0005515	protein binding	Cldn1	IPI	PR:P39447	Mouse	PMID:11689568
Molecular Function	GO:0005515	protein binding	Cldn1	IPI	PR:Q8VBX6	Mouse	PMID:11689568
Molecular Function	GO:0001618	virus receptor activity	CLDN1	IMP		Human	PMID:20375010
Cellular Component	GO:0016324	apical plasma membrane	Cldn1	IDA		Mouse	PMID:20089884
Cellular Component	GO:0016324	apical plasma membrane	Cldn1	IDA		Rat	PMID:22001439\|RGD:8655996
Cellular Component	GO:0016323	basolateral plasma membrane	CLDN1	IDA		Human	PMID:20375010
Cellular Component	GO:0005923	bicellular tight junction	CLDN1	IDA		Human	PMID:20375010
Cellular Component	GO:0005923	bicellular tight junction	CLDN1	IDA		Human	PMID:23407391
Cellular Component	GO:0005923	bicellular tight junction	CLDN1	IDA		Human	PMID:25849148
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	MGI:MGI:2176640\|PMID:11889141
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	MGI:MGI:1274767\|PMID:9647647
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	PMID:22946046
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	PMID:12673830
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	PMID:16520537
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	PMID:22275141
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Rat	PMID:11159859\|RGD:68224
Cellular Component	GO:0005923	bicellular tight junction	Cldn1	IDA		Rat	PMID:19929946\|RGD:2325127
Cellular Component	GO:0030054	cell junction	Cldn1	IDA		Mouse	MGI:MGI:5619454\|PMID:21983942
Cellular Component	GO:0005911	cell-cell junction	Cldn1	IDA		Mouse	MGI:MGI:6368952\|PMID:12734665
Cellular Component	GO:0005737	cytoplasm	Cldn1	IDA		Rat	PMID:10841351\|RGD:11344893
Cellular Component	GO:0016328	lateral plasma membrane	Cldn1	IDA		Mouse	PMID:22275141
Cellular Component	GO:0016328	lateral plasma membrane	Cldn1	IDA		Rat	PMID:11159859\|RGD:68224
Cellular Component	GO:0005886	plasma membrane	CLDN1	IDA		Human	PMID:11090614
Cellular Component	GO:0005886	plasma membrane	CLDN1	IMP		Human	PMID:23407391
Cellular Component	GO:0005886	plasma membrane	Cldn1	IDA		Mouse	MGI:MGI:2176640\|PMID:11889141
Cellular Component	GO:0005886	plasma membrane	Cldn1	IDA		Mouse	PMID:15775979
Cellular Component	GO:0032991	protein-containing complex	CLDN1	IDA		Human	PMID:25849148
Cellular Component	GO:0032991	protein-containing complex	CLDN1	IDA		Human	PMID:26607202
Cellular Component	GO:0070160	tight junction	CLDN1	IDA		Human	PMID:30734065
Cellular Component	GO:0070160	tight junction	Cldn1	IDA		Mouse	MGI:MGI:6369916\|PMID:30734065
Biological Process	GO:0007568	aging	Cldn1	IEP		Rat	PMID:17239013\|RGD:11344878
Biological Process	GO:0070830	bicellular tight junction assembly	CLDN1	IMP		Human	PMID:25849148
Biological Process	GO:0070830	bicellular tight junction assembly	CLDN1	IMP		Human	PMID:26607202
Biological Process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	Cldn1	IDA		Mouse	MGI:MGI:3687671\|PMID:10508613
Biological Process	GO:0034331	cell junction maintenance	Cldn1	IMP		Mouse	MGI:MGI:6368952\|PMID:12734665
Biological Process	GO:0045216	cell-cell junction organization	CLDN1	IMP		Human	PMID:20164257
Biological Process	GO:1903545	cellular response to butyrate	Cldn1	IEP		Rat	PMID:22684624\|RGD:11341733
Biological Process	GO:0071284	cellular response to lead ion	Cldn1	IEP		Rat	PMID:17439918\|RGD:11344879
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Cldn1	IEP		Rat	PMID:18031476\|RGD:11344898
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cldn1	IEP		Rat	PMID:21748286\|RGD:11341809
Biological Process	GO:0071346	cellular response to type II interferon	Cldn1	IEP		Rat	PMID:18768927\|RGD:11344890
Biological Process	GO:0008065	establishment of blood-nerve barrier	Cldn1	IMP		Rat	PMID:22733753\|RGD:11341802
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	Cldn1	IMP		Rat	PMID:22684624\|RGD:11341733
Biological Process	GO:0061436	establishment of skin barrier	CLDN1	IMP		Human	PMID:23407391
Biological Process	GO:0061436	establishment of skin barrier	Cldn1	IMP		Mouse	MGI:MGI:2176640\|PMID:11889141
Biological Process	GO:0042538	hyperosmotic salinity response	Cldn1	IEP		Rat	PMID:22733753\|RGD:11341802
Biological Process	GO:0097421	liver regeneration	Cldn1	IEP		Rat	PMID:15826721\|RGD:11344894
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	Cldn1	IMP		Rat	PMID:22684624\|RGD:11341733
Biological Process	GO:0030335	positive regulation of cell migration	CLDN1	IMP		Human	PMID:28412298
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	CLDN1	IMP		Human	PMID:28412298
Biological Process	GO:0090303	positive regulation of wound healing	CLDN1	IMP		Human	PMID:28412298
Biological Process	GO:0051259	protein complex oligomerization	CLDN1	IDA		Human	PMID:23704991
Biological Process	GO:0071548	response to dexamethasone	Cldn1	IEP		Rat	PMID:17897557\|RGD:11344897
Biological Process	GO:0045471	response to ethanol	Cldn1	IEP		Rat	PMID:17889313\|RGD:11344881
Biological Process	GO:0070673	response to interleukin-18	Cldn1	IMP		Rat	PMID:22001439\|RGD:8655996
Biological Process	GO:0032496	response to lipopolysaccharide	Cldn1	IEP		Rat	PMID:22092031\|RGD:11344891
Biological Process	GO:0009636	response to toxic substance	Cldn1	IEP		Rat	PMID:17120308\|RGD:1599550
Biological Process	GO:0061772	xenobiotic transport across blood-nerve barrier	Cldn1	IMP		Rat	PMID:22733753\|RGD:11341802

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.