Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK5RAP3
  • Mouse genes Cdk5rap3
  • Rat genes Cdk5rap3
  • Zfish genes cdk5rap3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk5rap3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030332	cyclin binding	CDK5RAP3	IPI	UniProtKB:P14635	Human	PMID:15790566
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	CDK5RAP3	IPI	UniProtKB:Q00987	Human	PMID:16173922
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	CDK5RAP3	IPI	UniProtKB:Q16539	Human	PMID:21283629
Molecular Function	GO:0051059	NF-kappaB binding	CDK5RAP3	IPI	UniProtKB:Q04206	Human	PMID:17785205
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:Q8N726-1	Human	PMID:16173922
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:Q04206	Human	PMID:17785205
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O94874	Human	PMID:20164180
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O94874	Human	PMID:20228063
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:Q96HY6	Human	PMID:20228063
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O75344	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:Q9UJ04	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O75344	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O75344	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O75344	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:O94874	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK5RAP3	IPI	UniProtKB:Q9UJ04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cdk5rap3	IPI	UniProtKB:P61961	Mouse	MGI:MGI:5613470|PMID:21494687
Molecular Function	GO:0005515	protein binding	Cdk5rap3	IPI	UniProtKB:Q8CCJ3	Mouse	MGI:MGI:6284072|PMID:30635284
Molecular Function	GO:0005515	protein binding	Cdk5rap3	IPI	PR:P45481	Mouse	PMID:16012757
Molecular Function	GO:0019901	protein kinase binding	CDK5RAP3	IPI	UniProtKB:O14757	Human	PMID:19223857
Molecular Function	GO:0044877	protein-containing complex binding	Cdk5rap3	IDA		Rat	PMID:10721722|RGD:632478
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	CDK5RAP3	IDA		Human	PMID:20531390
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	Cdk5rap3	IPI	UniProtKB:Q8CCJ3	Mouse	MGI:MGI:5613470|PMID:21494687
Cellular Component	GO:0005813	centrosome	CDK5RAP3	IDA		Human	PMID:19223857
Cellular Component	GO:0005737	cytoplasm	CDK5RAP3	IDA		Human	PMID:15790566
Cellular Component	GO:0005737	cytoplasm	CDK5RAP3	IDA		Human	PMID:16173922
Cellular Component	GO:0005737	cytoplasm	CDK5RAP3	IDA		Human	PMID:19223857
Cellular Component	GO:0005737	cytoplasm	CDK5RAP3	IDA		Human	PMID:20531390
Cellular Component	GO:0005737	cytoplasm	Cdk5rap3	IMP		Mouse	MGI:MGI:6284072|PMID:30635284
Cellular Component	GO:0005829	cytosol	CDK5RAP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CDK5RAP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	CDK5RAP3	HDA		Human	PMID:19946888
Cellular Component	GO:0005874	microtubule	CDK5RAP3	IDA		Human	PMID:23478299
Cellular Component	GO:0005730	nucleolus	CDK5RAP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDK5RAP3	IDA		Human	PMID:16173922
Cellular Component	GO:0032991	protein-containing complex	CDK5RAP3	IDA		Human	PMID:20531390
Biological Process	GO:0030262	apoptotic nuclear changes	CDK5RAP3	IMP		Human	PMID:23478299
Biological Process	GO:0008283	cell population proliferation	CDK5RAP3	IDA		Human	PMID:12054757
Biological Process	GO:0070586	cell-cell adhesion involved in gastrulation	cdk5rap3	IMP	ZFIN:ZDB-MRPHLNO-110609-3	Zfish	PMID:21523853
Biological Process	GO:0060318	definitive erythrocyte differentiation	Cdk5rap3	IMP		Mouse	MGI:MGI:6284072|PMID:30635284
Biological Process	GO:0009950	dorsal/ventral axis specification	cdk5rap3	IGI	ZFIN:ZDB-GENE-980526-474	Zfish	PMID:26475862
Biological Process	GO:0009950	dorsal/ventral axis specification	cdk5rap3	IGI	ZFIN:ZDB-GENE-040426-2575	Zfish	PMID:26475862
Biological Process	GO:0009950	dorsal/ventral axis specification	cdk5rap3	IGI	ZFIN:ZDB-GENE-990714-3,ZFIN:ZDB-GENE-990714-4	Zfish	PMID:26475862
Biological Process	GO:0009950	dorsal/ventral axis specification	cdk5rap3	IMP	ZFIN:ZDB-MRPHLNO-110609-3	Zfish	PMID:26475862
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	CDK5RAP3	IMP		Human	PMID:23152784
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cdk5rap3	IMP	ZFIN:ZDB-MRPHLNO-110609-3	Zfish	PMID:21523853
Biological Process	GO:0001889	liver development	Cdk5rap3	IMP		Mouse	MGI:MGI:6284072|PMID:30635284
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	CDK5RAP3	IMP		Human	PMID:15790566
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	CDK5RAP3	IMP		Human	PMID:19223857
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	Cdk5rap3	IDA		Rat	PMID:10721722|RGD:632478
Biological Process	GO:0043407	negative regulation of MAP kinase activity	CDK5RAP3	IMP		Human	PMID:21283629
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CDK5RAP3	IMP		Human	PMID:17785205
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CDK5RAP3	IMP		Human	PMID:20228063
Biological Process	GO:0042177	negative regulation of protein catabolic process	CDK5RAP3	IDA		Human	PMID:16173922
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	CDK5RAP3	IMP		Human	PMID:21283629
Biological Process	GO:0001933	negative regulation of protein phosphorylation	CDK5RAP3	IMP		Human	PMID:17785205
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	CDK5RAP3	IMP		Human	PMID:19223857
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	cdk5rap3	IMP	ZFIN:ZDB-MRPHLNO-110609-3	Zfish	PMID:26475862
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	cdk5rap3	IGI	ZFIN:ZDB-GENE-040426-2575	Zfish	PMID:26475862
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	cdk5rap3	IGI	ZFIN:ZDB-GENE-990714-3,ZFIN:ZDB-GENE-990714-4	Zfish	PMID:26475862
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	CDK5RAP3	IDA		Human	PMID:16173922
Biological Process	GO:0031398	positive regulation of protein ubiquitination	CDK5RAP3	IDA		Human	PMID:16173922
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	CDK5RAP3	IDA		Human	PMID:16173922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cdk5rap3	IGI	MGI:MGI:1098280	Mouse	PMID:16012757
Biological Process	GO:0071569	protein ufmylation	CDK5RAP3	IDA		Human	PMID:23152784
Biological Process	GO:0071569	protein ufmylation	CDK5RAP3	IMP		Human	PMID:30635284
Biological Process	GO:0071569	protein ufmylation	Cdk5rap3	IMP		Mouse	MGI:MGI:6284072|PMID:30635284
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	Cdk5rap3	IDA		Rat	PMID:10721722|RGD:632478
Biological Process	GO:0007346	regulation of mitotic cell cycle	cdk5rap3	IMP	ZFIN:ZDB-MRPHLNO-110609-3	Zfish	PMID:21523853
Biological Process	GO:0010921	regulation of phosphatase activity	CDK5RAP3	IMP		Human	PMID:21283629
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Cdk5rap3	IMP		Mouse	MGI:MGI:6284072|PMID:30635284

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern