Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD226
  • Mouse genes Cd226
  • Rat genes Cd226
  • Zfish genes cd226
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd226

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	CD226	IPI	UniProtKB:P15151	Human	PMID:12913096
Molecular Function	GO:0050839	cell adhesion molecule binding	CD226	IPI	UniProtKB:Q92692	Human	PMID:12913096
Molecular Function	GO:0042802	identical protein binding	CD226	IPI	UniProtKB:Q15762	Human	PMID:25465800
Molecular Function	GO:0042802	identical protein binding	CD226	IPI	UniProtKB:Q15762	Human	PMID:30591568
Molecular Function	GO:0005178	integrin binding	CD226	IPI	UniProtKB:P05107	Human	PMID:16831868
Molecular Function	GO:0005515	protein binding	CD226	IPI	UniProtKB:P15151	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CD226	IPI	UniProtKB:Q92692	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CD226	IPI	UniProtKB:Q495A1	Human	PMID:25465800
Molecular Function	GO:0005515	protein binding	CD226	IPI	UniProtKB:Q92692	Human	PMID:26755705
Molecular Function	GO:0005515	protein binding	CD226	IPI	UniProtKB:P15151	Human	PMID:30591568
Molecular Function	GO:0005515	protein binding	Cd226	IPI	UniProtKB:P15151	Mouse	MGI:MGI:6488796|PMID:30591568
Molecular Function	GO:0005515	protein binding	Cd226	IPI	MGI:MGI:107741	Mouse	PMID:15752754
Molecular Function	GO:0005515	protein binding	Cd226	IPI	PR:P32507	Mouse	PMID:15752754
Molecular Function	GO:0005515	protein binding	Cd226	IPI	MGI:MGI:107741	Mouse	PMID:21416464
Molecular Function	GO:0005515	protein binding	Cd226	IPI	MGI:MGI:107741	Mouse	PMID:24658051
Molecular Function	GO:0019901	protein kinase binding	CD226	IPI	UniProtKB:P06241	Human	PMID:16831868
Cellular Component	GO:0009986	cell surface	CD226	IDA		Human	PMID:16831868
Cellular Component	GO:0009897	external side of plasma membrane	Cd226	IDA		Mouse	PMID:19648922
Biological Process	GO:0001816	cytokine production	Cd226	IDA		Mouse	PMID:15752754
Biological Process	GO:0002370	natural killer cell cytokine production	Cd226	IMP	MGI:MGI:4454325	Mouse	PMID:24658051
Biological Process	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	CD226	IDA		Human	PMID:16831868
Biological Process	GO:0002891	positive regulation of immunoglobulin mediated immune response	CD226	IDA		Human	PMID:16831868
Biological Process	GO:0033005	positive regulation of mast cell activation	CD226	IDA		Human	PMID:16831868
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	Cd226	IMP	MGI:MGI:4454325	Mouse	PMID:24658051
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	CD226	IMP		Human	PMID:16304049
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	CD226	IMP		Human	PMID:12913096
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	CD226	IMP		Human	PMID:26755705
Biological Process	GO:0032729	positive regulation of type II interferon production	Cd226	IMP	MGI:MGI:4454325	Mouse	PMID:24658051

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern