About   Help   FAQ
Cd226 Gene Detail
Summary
  • Symbol
    Cd226
  • Name
    CD226 antigen
  • Synonyms
    DNAM1, DNAM-1, Pta1, TLiSA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039602
    NCBI Gene: 225825
  • Gene Overview
    MyGene.info: CD226
Location & Maps
more
  • Sequence Map
    Chr18:89197431-89270201 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72771 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 59.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CD226, CD226 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD226, CD226 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAM1, DNAM-1, PTA1, TLiSA1
  • Links
    NCBI Gene ID: 10666
    neXtProt AC: NX_Q15762

  • Chr Location
    18q22.3; chr18:69859459-69961787 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Cd226
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and increased incidence of tumor formation and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014908 VEGA Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
transcript OTTMUST00000035415 VEGA | MGI Sequence Detail 2357 Not Applicable  
polypeptide OTTMUSP00000015835 VEGA | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    370 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:79321 Sherrington PD, et al., TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. J Biol Chem. 1997 Aug 29;272(35):21735-44
  • Latest
    J:228168 Martinet L, et al., DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 2015 Apr 7;11(1):85-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory