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Cd226 Gene Detail
Summary
  • Symbol
    Cd226
  • Name
    CD226 antigen
  • Synonyms
    DNAM1, DNAM-1, Pta1, TLiSA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039602
    NCBI Gene: 225825
  • Gene Overview
    MyGene.info: CD226
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:89197431-89270201 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 59.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039602
protein coding gene Chr18:89176954-89272232 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024617
protein coding gene Chr18:90548695-90624119 (+)
A/J MGP_AJ_G0024584
protein coding gene Chr18:86507990-86581496 (+)
AKR/J MGP_AKRJ_G0024555
protein coding gene Chr18:89113190-89189656 (+)
BALB/cJ MGP_BALBcJ_G0024582
protein coding gene Chr18:86782706-86858218 (+)
C3H/HeJ MGP_C3HHeJ_G0024351
protein coding gene Chr18:89264711-89339948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025030
protein coding gene Chr18:92855606-92932451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022460
protein coding gene Chr18:85237912-85311902 (+)
CAST/EiJ MGP_CASTEiJ_G0023823
protein coding gene Chr18:89734141-89811753 (+)
CBA/J MGP_CBAJ_G0024321
protein coding gene Chr18:96166301-96250301 (+)
DBA/2J MGP_DBA2J_G0024450
protein coding gene Chr18:86060785-86138025 (+)
FVB/NJ MGP_FVBNJ_G0024417
protein coding gene Chr18:85387304-85467761 (+)
LP/J MGP_LPJ_G0024535
protein coding gene Chr18:90408799-90485890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024447
protein coding gene Chr18:98024457-98125712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025078
protein coding gene Chr18:89410739-89486044 (+)
PWK/PhJ MGP_PWKPhJ_G0023569
protein coding gene Chr18:86425863-86500262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023376
protein coding gene Chr18:89394149-89472997 (+)
WSB/EiJ MGP_WSBEiJ_G0023886
protein coding gene Chr18:89315647-89391864 (+)



Homology
more
  • Human Ortholog
    CD226, CD226 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD226, CD226 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAM1, DNAM-1, PTA1, TLiSA1
  • Links
    NCBI Gene ID: 10666
    neXtProt AC: NX_Q15762
    UniProt: Q15762

  • Chr Location
    18q22.2; chr18:69860228-69962086 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and increased incidence of tumor formation and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034028 Ensembl Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
transcript ENSMUST00000037142 Ensembl | MGI Sequence Detail 2357 Not Applicable  
polypeptide ENSMUSP00000043551 Ensembl | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 20
  • Earliest
    J:79321 Sherrington PD, et al., TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. J Biol Chem. 1997 Aug 29;272(35):21735-44
  • Latest
    J:248886 Kraus AK, et al., The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. PLoS One. 2016;11(2):e0147951

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory