Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCN4
  • Mouse genes Ccn4
  • Rat genes Ccn4
  • Zfish genes ccn4a,ccn4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CCN4	IPI	UniProtKB:P07585	Human	PMID:11598131
Molecular Function	GO:0005515	protein binding	CCN4	IPI	UniProtKB:P21810	Human	PMID:11598131
Molecular Function	GO:0005515	protein binding	CCN4	IPI	UniProtKB:P21274	Human	PMID:20684029
Molecular Function	GO:0005515	protein binding	CCN4	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN4	IPI	UniProtKB:P49639	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Ccn4	IMP		Mouse	MGI:MGI:6294174|PMID:28496206
Cellular Component	GO:0005829	cytosol	CCN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	CCN4	IDA		Human	PMID:25281430
Cellular Component	GO:0005615	extracellular space	Ccn4	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0060348	bone development	Ccn4	IMP		Mouse	MGI:MGI:6294593|PMID:15331410
Biological Process	GO:0060348	bone development	Ccn4	IMP		Mouse	MGI:MGI:5788182|PMID:25864198
Biological Process	GO:0042593	glucose homeostasis	Ccn4	IMP		Mouse	MGI:MGI:6294201|PMID:29319180
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Ccn4	IMP		Mouse	MGI:MGI:6294593|PMID:15331410
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Ccn4	IDA		Mouse	MGI:MGI:6294174|PMID:28496206
Biological Process	GO:0001649	osteoblast differentiation	Ccn4	IMP		Mouse	MGI:MGI:6294593|PMID:15331410
Biological Process	GO:0030316	osteoclast differentiation	Ccn4	IMP		Mouse	MGI:MGI:5788182|PMID:25864198
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Ccn4	IMP		Rat	PMID:21376054|RGD:5129173
Biological Process	GO:0050729	positive regulation of inflammatory response	CCN4	IDA		Human	PMID:25281430
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	CCN4	IMP		Human	PMID:20684029
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Ccn4	IMP		Rat	PMID:23807044|RGD:10003107
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ccn4	IMP		Rat	PMID:23807044|RGD:10003107
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Ccn4	IMP		Mouse	MGI:MGI:5788182|PMID:25864198
Biological Process	GO:0090303	positive regulation of wound healing	Ccn4	IMP		Mouse	MGI:MGI:6196779|PMID:29330021
Biological Process	GO:0001817	regulation of cytokine production	CCN4	IDA		Human	PMID:25281430

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern