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Wisp1
Gene Detail
Symbol

Name
ID
Wisp1
WNT1 inducible signaling pathway protein 1
MGI:1197008
Synonyms
CCN4, Elm1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:66891320-66923201 bp, + strand
From VEGA annotation of GRCm38

  31882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: WISP1
Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Wisp1

Human
homologs
WISP1, WNT1 inducible signaling pathway protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8840
neXtProt AC: NX_O95388

Human Synonyms: CCN4, WISP1c, WISP1i, WISP1tc

Human Chr (Location): 8q24.22; chr8:133191039-133231690 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Wisp1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit impaired motor coordination during inverted screen testing.
 
Phenotype Images(2)
Interactions
Wisp1 interacts with 333 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, cell-cell signaling, ...
Component cytoplasm, extracellular region, ...
Function heparin binding, insulin-like growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (530)    Tissues (102)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 529
RT-PCR 1
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WISP1 ZFIN wisp1b    NEW 
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028045 (Evidence)
Ensembl Gene Model ENSMUSG00000005124 (Evidence)
Entrez Gene 22402 (Evidence)
DFCI TC1580552, TC1656041, TC1590598
DoTS DT.101291194, DT.110834258, DT.40171558
NIA Mouse Gene Index U016306
Consensus CDS Project CCDS27510.1
International Mouse Phenotyping Consortium Status Wisp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028045 VEGA Gene Model | MGI Sequence Detail 31882 C57BL/6J ±  kb
transcript OTTMUST00000069450 VEGA | MGI Sequence Detail 5097 Not Applicable 
polypeptide OTTMUSP00000035271 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(389 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR012395 IGFBP-related, CNN
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000017426 WNT1-inducible-signaling pathway protein 1
References
(Earliest) J:45694 Hashimoto Y, et al., Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells. J Exp Med. 1998 Feb 2;187(3):289-96
(Latest) J:180791 Saravanamuthu SS, et al., Conditional ablation of the Notch2 receptor in the ocular lens. Dev Biol. 2012 Feb 15;362(2):219-29
All references(41)
Other
accession IDs
MGI:2146202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory