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Ccn4 Gene Detail
Summary
  • Symbol
    Ccn4
  • Name
    cellular communication network factor 4
  • Synonyms
    CCN4, Elm1, Wisp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197008
    NCBI Gene: 22402
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66891325-66923205 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197008
protein coding gene Chr15:66891320-66923205 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021909
protein coding gene Chr15:66414761-66446627 (+)
A/J MGP_AJ_G0021868
protein coding gene Chr15:63903765-63935828 (+)
AKR/J MGP_AKRJ_G0021850
protein coding gene Chr15:65668732-65700653 (+)
BALB/cJ MGP_BALBcJ_G0021875
protein coding gene Chr15:64087057-64118929 (+)
C3H/HeJ MGP_C3HHeJ_G0021648
protein coding gene Chr15:65791108-65822980 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022314
protein coding gene Chr15:68989335-69021192 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019851
protein coding gene Chr15:60683735-60715589 (+)
CAST/EiJ MGP_CASTEiJ_G0021167
protein coding gene Chr15:66451922-66484243 (+)
CBA/J MGP_CBAJ_G0021614
protein coding gene Chr15:71277512-71309384 (+)
DBA/2J MGP_DBA2J_G0021739
protein coding gene Chr15:63685918-63717798 (+)
FVB/NJ MGP_FVBNJ_G0021721
protein coding gene Chr15:62723153-62754974 (+)
LP/J MGP_LPJ_G0021811
protein coding gene Chr15:66309067-66340946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021744
protein coding gene Chr15:76377108-76409038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022336
protein coding gene Chr15:66043906-66075841 (+)
PWK/PhJ MGP_PWKPhJ_G0020908
protein coding gene Chr15:63784530-63816982 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020749
protein coding gene Chr15:65916192-65949741 (+)
WSB/EiJ MGP_WSBEiJ_G0021219
protein coding gene Chr15:66014414-66046256 (+)



Homology
more
  • Human Ortholog
    CCN4, cellular communication network factor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CCN4, cellular communication network factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WISP1, WISP1c, WISP1i, WISP1-OT1, WISP1tc, WISP1-UT1
  • Links
    NCBI Gene ID: 8840
    neXtProt AC: NX_O95388
    UniProt: O95388

  • Chr Location
    8q24.22; chr8:133191039-133231690 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit impaired motor coordination during inverted screen testing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22402 NCBI Gene Model | MGI Sequence Detail 31881 C57BL/6J ±  kb
transcript NM_018865 RefSeq | MGI Sequence Detail 5048 C57BL/6  
polypeptide O54775 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017426 WNT1-inducible-signaling pathway protein 1
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR012395 IGFBP-related, CNN
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146202
References
more
  • Summaries
    All 76
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:264594 Ono M, et al., CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via alpha5beta1 and TNFalpha. Matrix Biol. 2018 Aug;68-69:533-546

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory