Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CA4
  • Mouse genes Car4
  • Rat genes Car4
  • Zfish genes ca4a,ca4b,ca4c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Car4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004089	carbonate dehydratase activity	Car4	IDA		Mouse	PMID:16083424
Molecular Function	GO:0004089	carbonate dehydratase activity	Car4	IDA		Mouse	PMID:14660577
Molecular Function	GO:0004089	carbonate dehydratase activity	Car4	IDA		Rat	PMID:1533109|RGD:1600753
Molecular Function	GO:0005515	protein binding	CA4	IPI	UniProtKB:Q9Y6R1	Human	PMID:15563508
Molecular Function	GO:0005515	protein binding	Car4	IPI	UniProtKB:O88343	Mouse	MGI:MGI:5499727|PMID:14567693
Cellular Component	GO:0016324	apical plasma membrane	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0016324	apical plasma membrane	Car4	IDA		Rat	PMID:8675662|RGD:1600751
Cellular Component	GO:0031526	brush border membrane	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0009986	cell surface	CA4	IDA		Human	PMID:15563508
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0009897	external side of plasma membrane	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0070062	extracellular exosome	CA4	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	CA4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CA4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CA4	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0016020	membrane	Car4	IDA		Mouse	PMID:16083424
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0005886	plasma membrane	CA4	IDA		Human	PMID:15563508
Cellular Component	GO:0005886	plasma membrane	Car4	IDA		Mouse	PMID:16083424
Cellular Component	GO:0005791	rough endoplasmic reticulum	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0042383	sarcolemma	Car4	IDA		Rat	PMID:8911968|RGD:1600749
Cellular Component	GO:0016529	sarcoplasmic reticulum	Car4	IDA		Rat	PMID:8911968|RGD:1600749
Cellular Component	GO:0030667	secretory granule membrane	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0005802	trans-Golgi network	CA4	IDA		Human	PMID:17409381
Cellular Component	GO:0030658	transport vesicle membrane	CA4	IDA		Human	PMID:17409381
Biological Process	GO:0048513	animal organ development	Car4	IEP		Rat	PMID:12852484|RGD:1600746
Biological Process	GO:0015701	bicarbonate transport	CA4	IMP		Human	PMID:15563508
Biological Process	GO:0048545	response to steroid hormone	Car4	IEP		Rat	PMID:10569998|RGD:1600748
Biological Process	GO:0009410	response to xenobiotic stimulus	Car4	IEP		Rat	PMID:16144999|RGD:1600731

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern