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Car4 Gene Detail
Summary
  • Symbol
    Car4
  • Name
    carbonic anhydrase 4
  • Synonyms
    CA IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096574
    NCBI Gene: 12351
  • Gene Overview
    MyGene.info: CA4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:84957786-84966044 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096574
protein coding gene Chr11:84957754-84966054 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018877
protein coding gene Chr11:86424399-86432657 (+)
A/J MGP_AJ_G0018844
protein coding gene Chr11:83121551-83129809 (+)
AKR/J MGP_AKRJ_G0018814
protein coding gene Chr11:85588584-85596841 (+)
BALB/cJ MGP_BALBcJ_G0018817
protein coding gene Chr11:83511045-83519299 (+)
C3H/HeJ MGP_C3HHeJ_G0018631
protein coding gene Chr11:85638853-85647774 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019269
protein coding gene Chr11:89051347-89059605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016902
protein coding gene Chr11:80206076-80214797 (+)
CAST/EiJ MGP_CASTEiJ_G0018186
protein coding gene Chr11:86272828-86280887 (+)
CBA/J MGP_CBAJ_G0018602
protein coding gene Chr11:92847302-92855560 (+)
DBA/2J MGP_DBA2J_G0018710
protein coding gene Chr11:82693727-82701984 (+)
FVB/NJ MGP_FVBNJ_G0018699
protein coding gene Chr11:82184561-82192808 (+)
LP/J MGP_LPJ_G0018780
protein coding gene Chr11:86943551-86951884 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018726
protein coding gene Chr11:92956605-92966205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019309
protein coding gene Chr11:85865833-85874099 (+)
PWK/PhJ MGP_PWKPhJ_G0017955
protein coding gene Chr11:83470813-83479342 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017747
protein coding gene Chr11:85410104-85418408 (+)
WSB/EiJ MGP_WSBEiJ_G0018237
protein coding gene Chr11:85704500-85714426 (+)



Homology
more
  • Human Ortholog
    CA4, carbonic anhydrase 4
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CA4, carbonic anhydrase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAIV, Car4, RP17
  • Links
    NCBI Gene ID: 762
    neXtProt AC: NX_P22748
    UniProt: P22748

  • Chr Location
    17q23.1; chr17:60149941-60178118 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are produced in lower than expected numbers, with females preferentially lost in the fetal or early postnatal period. Surviving homozygotes are healthy and fertile when crossed with wild-type partners; however, homozygous intercrosses yield small litters and pups do not survive.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000805 Ensembl Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
    transcript ENSMUST00000103194 Ensembl | MGI Sequence Detail 1256 Not Applicable  
    polypeptide ENSMUSP00000099483 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 7
      cDNA 78
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144530
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory