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Car4 Gene Detail
Summary
  • Symbol
    Car4
  • Name
    carbonic anhydrase 4
  • Synonyms
    CA IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096574
    NCBI Gene: 12351
  • Gene Overview
    MyGene.info: CA4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:84957786-84966044 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CA4, carbonic anhydrase 4
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CA4, carbonic anhydrase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAIV, Car4, RP17
  • Links
    NCBI Gene ID: 762
    neXtProt AC: NX_P22748
    UniProt: P22748

  • Chr Location
    17q23.1; chr17:60149941-60178118 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are produced in lower than expected numbers, with females preferentially lost in the fetal or early postnatal period. Surviving homozygotes are healthy and fertile when crossed with wild-type partners; however, homozygous intercrosses yield small litters and pups do not survive.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001034 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
    transcript OTTMUST00000002065 VEGA | MGI Sequence Detail 1256 Not Applicable  
    polypeptide OTTMUSP00000001000 VEGA | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      51 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 7
      cDNA 78
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144530
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory