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Car4
Gene Detail
Symbol

Name
ID
Car4
carbonic anhydrase 4
MGI:1096574
Synonyms
CA IV
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:84957786-84966044 bp, + strand
From VEGA annotation of GRCm38

  8259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car4

Human
homologs
Human Homolog CA4, carbonic anhydrase IV
NCBI Gene ID 762
neXtProt AC  NX_P22748
Human Synonyms  CAIV, Car4, RP17
Human Chr (Location)  17q23; chr17:60149941-60159546 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are produced in lower than expected numbers, with females preferentially lost in the fetal or early postnatal period. Surviving homozygotes are healthy and fertile when crossed with wild-type partners; however, homozygous intercrosses yield small litters and pups do not survive.
 
Interactions
Car4 interacts with 72 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (160)    Tissues (145)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 158
RT-PCR 2
cDNA source data(77)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(7) cDNA(77) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001034 (Evidence)
Ensembl Gene ModelENSMUSG00000000805 (Evidence)
Entrez Gene12351 (Evidence)
UniGene1641
DFCITC1576825
DoTSDT.533723
NIA Mouse Gene IndexU013114
EC4.2.1.1
PDB2ZNC, 3ZNC
Consensus CDS ProjectCCDS25190.1
International Mouse Knockout Project StatusCar4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001034 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
transcript OTTMUST00000002065 VEGA | MGI Sequence Detail 1256 Not Applicable 
polypeptide OTTMUSP00000001000 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018343 Carbonic anhydrase, CA-IV
Protein Ontology PR:000004920 carbonic anhydrase 4
References
(Earliest) J:18790 Brion LP, et al., Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of mice genetically deficient in carbonic anhydrase II. J Neurochem. 1994 Jul;63(1):360-6
(Latest) J:193715 Schneider HP, et al., GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1494-9
All references(59)
Other
accession IDs
MGI:2144530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory