Car4
Gene Detail

Symbol Name ID

Car4 carbonic anhydrase 4 MGI:1096574

Synonyms

CA IV

Feature Type

protein coding gene

Genetic Map

Chromosome 11

51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:84957786-84966044 bp, + strand From VEGA annotation of GRCm38   8259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car4

Human homologs

Human Homolog		CA4, carbonic anhydrase IV
NCBI Gene ID		762
neXtProt AC		NX_P22748
Human Synonyms		CAIV, Car4, RP17
Human Chr (Location)		17q23; chr17:58227302-58236907 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CA4

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(9)
 

Homozygous null mice are produced in lower than expected numbers, with females preferentially lost in the fetal or early postnatal period. Surviving homozygotes are healthy and fertile when crossed with wild-type partners; however, homozygous intercrosses yield small litters and pups do not survive.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	bicarbonate transport, one-carbon metabolic process
Component	anchored to external side of plasma membrane, anchored to membrane, ...
Function	carbonate dehydratase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (106)    Tissues (97)    Images (13)
Theiler Stages: 15, 18, 22, 23

Assay Type	Results
RNA in situ	104
RT-PCR	2

cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(7) cDNA(77) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001034 (Evidence)
Ensembl Gene Model	ENSMUSG00000000805 (Evidence)
Entrez Gene	12351 (Evidence)
UniGene	1641
DFCI	TC1576825
DoTS	DT.533723
NIA Mouse Gene Index	U013114
EC	4.2.1.1
PDB	2ZNC, 3ZNC
Consensus CDS Project	CCDS25190.1
International Mouse Knockout Project Status	Car4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001034	VEGA Gene Model | MGI Sequence Detail	8259	C57BL/6J
transcript	OTTMUST00000002065	VEGA | MGI Sequence Detail	1256	Not Applicable
polypeptide	OTTMUSP00000001000	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR023561	Carbonic anhydrase, alpha-class
InterPro	IPR018338	Carbonic anhydrase, alpha-class, conserved site
InterPro	IPR018343	Carbonic anhydrase, CA-IV
Protein Ontology	PR:000004920	carbonic anhydrase 4

References

(Earliest) J:18790 Brion LP, et al., Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of mice genetically deficient in carbonic anhydrase II. J Neurochem. 1994 Jul;63(1):360-6
(Latest) J:193715 Schneider HP, et al., GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1494-9
All references(54)

Other accession IDs

MGI:2144530