Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNB2
  • Mouse genes Cacnb2
  • Rat genes Cacnb2
  • Zfish genes cacnb2a,cacnb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacnb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Cacnb2	IDA		Mouse	MGI:MGI:5770035|PMID:25533460
Molecular Function	GO:0051015	actin filament binding	Cacnb2	IDA		Rat	PMID:25533460|RGD:11059570
Molecular Function	GO:0005246	calcium channel regulator activity	Cacnb2	IDA		Rat	PMID:1370480|RGD:632405
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	CACNB2	IDA		Human	PMID:1309651
Molecular Function	GO:0042802	identical protein binding	Cacnb2	IPI	UniProtKB:Q8VGC3-2	Rat	PMID:18776052|RGD:13432277
Molecular Function	GO:0051219	phosphoprotein binding	Cacnb2	IPI	RGD:10284	Rat	PMID:19840220|RGD:7207260
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:O88667	Human	PMID:17525370
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:Q9UQM7	Human	PMID:28130356
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:O14744	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:P56545-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:Q8WUU8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNB2	IPI	UniProtKB:Q96MH2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cacnb2	IPI	PR:Q01815	Mouse	PMID:16787652
Molecular Function	GO:0005515	protein binding	Cacnb2	IPI	UniProtKB:E9Q1T1	Mouse	PMID:20877009
Molecular Function	GO:0005515	protein binding	Cacnb2	IPI	PR:O55017	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacnb2	IPI	PR:P97445	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacnb2	IPI	UniProtKB:Q66L44	Rat	PMID:24751537|RGD:10047103
Molecular Function	GO:0019904	protein domain specific binding	Cacnb2	IPI	RGD:10284	Rat	PMID:19840220|RGD:7207260
Molecular Function	GO:0019901	protein kinase binding	Cacnb2	IDA		Rat	PMID:18205403|RGD:7175532
Molecular Function	GO:0019901	protein kinase binding	Cacnb2	IPI	RGD:10284	Rat	PMID:19840220|RGD:7207260
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNB2	IDA		Human	PMID:1309651
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacnb2	IDA		Rat	PMID:16049183|RGD:1582495
Molecular Function	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential	CACNB2	IMP		Human	PMID:17224476
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNB2	IMP		Human	PMID:17224476
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacnb2	IMP		Mouse	PMID:11980879
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacnb2	IDA		Mouse	PMID:11980879
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	CACNB2	IDA		Human	PMID:1309651
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	Cacnb2	IDA		Rat	PMID:26680202|RGD:12907551
Cellular Component	GO:0098684	photoreceptor ribbon synapse	Cacnb2	IMP		Mouse	PMID:11980879
Cellular Component	GO:0098684	photoreceptor ribbon synapse	Cacnb2	IDA		Mouse	PMID:11980879
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNB2	IDA		Human	PMID:17224476
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacnb2	IDA		Mouse	PMID:10328888
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacnb2	IDA		Rat	PMID:16049183|RGD:1582495
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacnb2	IDA		Rat	PMID:19840220|RGD:7207260
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacnb2	IDA		Rat	PMID:21611731|RGD:7205480
Biological Process	GO:0070509	calcium ion import	CACNB2	IDA		Human	PMID:1309651
Biological Process	GO:0070588	calcium ion transmembrane transport	Cacnb2	IDA		Mouse	MGI:MGI:2429657|PMID:11980879
Biological Process	GO:0007268	chemical synaptic transmission	Cacnb2	IMP	MGI:MGI:2429694	Mouse	PMID:11980879
Biological Process	GO:0003143	embryonic heart tube morphogenesis	cacnb2a	IMP	ZFIN:ZDB-MRPHLNO-120511-10	Zfish	PMID:22274990
Biological Process	GO:0021782	glial cell development	cacnb2a	IMP	ZFIN:ZDB-CRISPR-191009-41,ZFIN:ZDB-CRISPR-191009-42	Zfish	PMID:30924555
Biological Process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential	CACNB2	IMP		Human	PMID:17224476
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	CACNB2	IMP		Human	PMID:17224476
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Cacnb2	IDA		Rat	PMID:25533460|RGD:11059570
Biological Process	GO:0051928	positive regulation of calcium ion transport	CACNB2	IDA		Human	PMID:1309651
Biological Process	GO:1901843	positive regulation of high voltage-gated calcium channel activity	Cacnb2	IDA		Rat	PMID:25533460|RGD:11059570
Biological Process	GO:0072659	protein localization to plasma membrane	Cacnb2	IDA		Rat	PMID:25533460|RGD:11059570
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNB2	IMP		Human	PMID:17224476
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Cacnb2	IDA		Mouse	MGI:MGI:2429657|PMID:11980879
Biological Process	GO:1901385	regulation of voltage-gated calcium channel activity	Cacnb2	IDA		Rat	PMID:12042350|RGD:632406
Biological Process	GO:0060041	retina development in camera-type eye	cacnb2a	IMP	ZFIN:ZDB-CRISPR-191009-41,ZFIN:ZDB-CRISPR-191009-42	Zfish	PMID:30924555
Biological Process	GO:0007601	visual perception	Cacnb2	IMP	MGI:MGI:2429694	Mouse	PMID:11980879

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern