Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes C8A
  • Mouse genes C8a
  • Rat genes C8a
  • Zfish genes c8a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C8a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001848	complement binding	C8a	IPI	RGD:1309074	Rat	PMID:3312411|RGD:1600696
Molecular Function	GO:0005515	protein binding	C8A	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C8A	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C8A	IPI	UniProtKB:Q6ZVE7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C8A	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C8A	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0044877	protein-containing complex binding	C8a	IPI	RGD:1309074|RGD:2239	Rat	PMID:3312411|RGD:1600696
Cellular Component	GO:0072562	blood microparticle	C8A	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	C8A	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	C8a	IDA		Rat	PMID:3312411|RGD:1600696
Cellular Component	GO:0005615	extracellular space	C8a	IDA		Rat	PMID:3312411|RGD:1600696
Cellular Component	GO:0005579	membrane attack complex	C8A	IPI		Human	PMID:30552328
Cellular Component	GO:0005579	membrane attack complex	C8A	IDA		Human	PMID:12413696
Cellular Component	GO:0005579	membrane attack complex	C8A	IDA		Human	PMID:22832194
Biological Process	GO:0006956	complement activation	C8A	IDA		Human	PMID:12413696

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern