| GO term: | complement activation |
| Synonym: | complement activity |
| Synonym: | complement cascade |
| Synonym: | complement response |
| GO id: | GO:0006956 |
| Definition: | Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. |
| Comments | This term was improved by GO_REF:0000022. It was moved. |
| Number of paths to term: | 32 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processbiological regulationregulation of biological processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processbiological regulationregulation of biological processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processbiological regulationregulation of biological processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processimmune effector processcell activation involved in immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +defense response to virus +encapsulation of foreign target +granuloma formation +immune complex clearance +immune response-regulating cell surface receptor signaling pathway involved in phagocytosis +induced systemic resistance, ethylene mediated signaling pathwayinduced systemic resistance, jasmonic acid mediated signaling pathwayleukocyte degranulation +leukocyte mediated cytotoxicity +leukocyte mediated immunity +leukocyte migration involved in immune response +negative regulation of immune effector process +opsonizationpositive regulation of immune effector process +regulation of immune effector process +respiratory burst involved in defense response +biological_processimmune system processimmune responsehumoral immune responseantimicrobial humoral response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +hemolymph coagulationhumoral immune response mediated by circulating immunoglobulin +negative regulation of humoral immune response +positive regulation of humoral immune response +regulation of humoral immune response +biological_processimmune system processimmune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processimmune responseregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processimmune system processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processprotein activation cascadeblood coagulation, common pathway +blood coagulation, extrinsic pathway +blood coagulation, fibrin clot formation +blood coagulation, intrinsic pathway +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +kinin cascade +negative regulation of protein activation cascade +positive regulation of protein activation cascade +regulation of protein activation cascade +biological_processmetabolic processprimary metabolic processprotein metabolic processprotein activation cascadeblood coagulation, common pathway +blood coagulation, extrinsic pathway +blood coagulation, fibrin clot formation +blood coagulation, intrinsic pathway +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +kinin cascade +negative regulation of protein activation cascade +positive regulation of protein activation cascade +regulation of protein activation cascade +biological_processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processregulation of biological processregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processresponse to stimulusimmune responsehumoral immune responseantimicrobial humoral response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +hemolymph coagulationhumoral immune response mediated by circulating immunoglobulin +negative regulation of humoral immune response +positive regulation of humoral immune response +regulation of humoral immune response +biological_processresponse to stimulusimmune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processresponse to stimulusimmune responseregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processresponse to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processresponse to stimulusprotein activation cascadeblood coagulation, common pathway +blood coagulation, extrinsic pathway +blood coagulation, fibrin clot formation +blood coagulation, intrinsic pathway +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +kinin cascade +negative regulation of protein activation cascade +positive regulation of protein activation cascade +regulation of protein activation cascade +biological_processresponse to stimulusregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processresponse to stimulusregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responseactivation of innate immune response +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +immune response-activating signal transduction +biological_processsingle-organism processprotein activation cascadeblood coagulation, common pathway +blood coagulation, extrinsic pathway +blood coagulation, fibrin clot formation +blood coagulation, intrinsic pathway +complement activation [GO:0006956] (46 genes, 86 annotations)activation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +kinin cascade +negative regulation of protein activation cascade +positive regulation of protein activation cascade +regulation of protein activation cascade +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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