Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BIRC5
  • Mouse genes Birc5
  • Rat genes Birc5
  • Zfish genes birc5a,birc5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Birc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	BIRC5	IPI	UniProtKB:Q93008	Human	PMID:16322459
Molecular Function	GO:0042802	identical protein binding	BIRC5	IPI	UniProtKB:O15392	Human	PMID:17099693
Molecular Function	GO:0042802	identical protein binding	BIRC5	IPI	UniProtKB:O15392	Human	PMID:23251006
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:14610074
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q13490	Human	PMID:15665297
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:16239925
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:16291752
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:O14980	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P06493	Human	PMID:17681274
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:17681274
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:17956729
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:17956729
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:18243099
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:O14965	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q14457	Human	PMID:20638385
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:20739936
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:O14980	Human	PMID:20826784
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P40763	Human	PMID:20826784
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NQS7	Human	PMID:21225229
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P98170	Human	PMID:21536684
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NR28	Human	PMID:21536684
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9UQB9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P62826	Human	PMID:23251006
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9NR28	Human	PMID:23251006
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P98164	Human	PMID:23825075
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q86XJ1	Human	PMID:24571573
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:24571573
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9UJT9	Human	PMID:25778398
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:27332895
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9UQB9	Human	PMID:27332895
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9UJT9	Human	PMID:28218735
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q15834	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P05067-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q7Z412	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q8TB36	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BIRC5	IPI	UniProtKB:Q9BXM7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Birc5	IPI	UniProtKB:Q5BJ29	Mouse	MGI:MGI:6368091|PMID:25778398
Molecular Function	GO:0005515	protein binding	Birc5	IPI	PR:Q8BHX3	Mouse	PMID:17881355
Molecular Function	GO:0051087	protein-folding chaperone binding	BIRC5	IPI	UniProtKB:P10809	Human	PMID:18086682
Molecular Function	GO:0031267	small GTPase binding	BIRC5	IPI	UniProtKB:P62826	Human	PMID:18591255
Cellular Component	GO:0016324	apical plasma membrane	Birc5	IDA		Rat	PMID:17982126|RGD:2293128
Cellular Component	GO:0032133	chromosome passenger complex	BIRC5	IPI		Human	PMID:17956729
Cellular Component	GO:0032133	chromosome passenger complex	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:15260989
Cellular Component	GO:0032133	chromosome passenger complex	BIRC5	IPI	UniProtKB:Q53HL2	Human	PMID:18591255
Cellular Component	GO:0032133	chromosome passenger complex	BIRC5	IPI	UniProtKB:Q96GD4	Human	PMID:18591255
Cellular Component	GO:0000775	chromosome, centromeric region	BIRC5	IDA		Human	PMID:11084331
Cellular Component	GO:0000775	chromosome, centromeric region	BIRC5	IDA		Human	PMID:16322459
Cellular Component	GO:0000775	chromosome, centromeric region	Birc5	IDA		Mouse	PMID:25645018
Cellular Component	GO:0005737	cytoplasm	BIRC5	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	BIRC5	IDA		Human	PMID:20627126
Cellular Component	GO:0005737	cytoplasm	BIRC5	IDA		Human	PMID:21364656
Cellular Component	GO:0005737	cytoplasm	Birc5	IDA		Mouse	PMID:12679106
Cellular Component	GO:0005737	cytoplasm	Birc5	IDA		Rat	PMID:18376799|RGD:2293123
Cellular Component	GO:0005829	cytosol	BIRC5	IDA		Human	PMID:18591255
Cellular Component	GO:0000776	kinetochore	BIRC5	IDA		Human	PMID:15665297
Cellular Component	GO:0015630	microtubule cytoskeleton	BIRC5	IDA		Human	PMID:9859993
Cellular Component	GO:0030496	midbody	BIRC5	IDA		Human	PMID:11084331
Cellular Component	GO:0030496	midbody	BIRC5	IDA		Human	PMID:15665297
Cellular Component	GO:0000228	nuclear chromosome	BIRC5	IDA		Human	PMID:16322459
Cellular Component	GO:0005634	nucleus	BIRC5	IDA		Human	PMID:15665297
Cellular Component	GO:0005634	nucleus	BIRC5	IDA		Human	PMID:20627126
Cellular Component	GO:0005634	nucleus	BIRC5	IDA		Human	PMID:20826784
Cellular Component	GO:0005634	nucleus	BIRC5	IDA		Human	PMID:21364656
Cellular Component	GO:0005634	nucleus	Birc5	IDA		Rat	PMID:12604914|RGD:2293139
Cellular Component	GO:1990713	survivin complex	BIRC5	IPI		Human	PMID:10949038
Biological Process	GO:0001525	angiogenesis	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1,ZFIN:ZDB-MRPHLNO-070725-2	Zfish	PMID:17511868
Biological Process	GO:0030953	astral microtubule organization	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0048514	blood vessel morphogenesis	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1,ZFIN:ZDB-MRPHLNO-070725-2	Zfish	PMID:17511868
Biological Process	GO:0071361	cellular response to ethanol	Birc5	IEP		Rat	PMID:20610854|RGD:9586044
Biological Process	GO:0036216	cellular response to stem cell factor stimulus	Birc5	IEP		Rat	PMID:15130521|RGD:9586041
Biological Process	GO:0009790	embryo development	Birc5	IMP	MGI:MGI:2681348	Mouse	PMID:11084331
Biological Process	GO:0007507	heart development	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:19323830
Biological Process	GO:0007507	heart development	birc5a	IMP	ZFIN:ZDB-GENO-040722-4	Zfish	PMID:19652097
Biological Process	GO:0007507	heart development	birc5a	IMP	ZFIN:ZDB-GENO-040722-3	Zfish	PMID:19652097
Biological Process	GO:0007507	heart development	birc5a	IMP	ZFIN:ZDB-GENO-040722-2	Zfish	PMID:19652097
Biological Process	GO:0007507	heart development	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:19323830
Biological Process	GO:0007127	meiosis I	Birc5	IDA		Mouse	PMID:25645018
Biological Process	GO:0045132	meiotic chromosome segregation	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0051311	meiotic metaphase plate congression	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0000226	microtubule cytoskeleton organization	Birc5	IMP	MGI:MGI:2681348	Mouse	PMID:11084331
Biological Process	GO:0007080	mitotic metaphase plate congression	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0090307	mitotic spindle assembly	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IDA		Human	PMID:10949038
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IDA		Human	PMID:20627126
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IDA		Human	PMID:21364656
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IMP		Human	PMID:21536684
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IMP		Human	PMID:25778398
Biological Process	GO:0043066	negative regulation of apoptotic process	BIRC5	IMP		Human	PMID:28218735
Biological Process	GO:0043066	negative regulation of apoptotic process	Birc5	IMP		Mouse	MGI:MGI:6368091|PMID:25778398
Biological Process	GO:0043066	negative regulation of apoptotic process	Birc5	IMP		Mouse	PMID:12679106
Biological Process	GO:0043066	negative regulation of apoptotic process	Birc5	IMP		Rat	PMID:12833149|RGD:724767
Biological Process	GO:0043066	negative regulation of apoptotic process	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:19323830
Biological Process	GO:0043066	negative regulation of apoptotic process	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:19323830
Biological Process	GO:0043066	negative regulation of apoptotic process	birc5b	IMP	ZFIN:ZDB-MRPHLNO-101105-3	Zfish	PMID:19151781
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	BIRC5	IMP		Human	PMID:20826784
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Birc5	IMP	MGI:MGI:2176173,MGI:MGI:3028474	Mouse	PMID:16049172
Biological Process	GO:0022008	neurogenesis	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:19323830
Biological Process	GO:0022008	neurogenesis	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:19323830
Biological Process	GO:0030182	neuron differentiation	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:21546908
Biological Process	GO:0030182	neuron differentiation	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:21546908
Biological Process	GO:0045766	positive regulation of angiogenesis	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:19323830
Biological Process	GO:0045766	positive regulation of angiogenesis	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:19323830
Biological Process	GO:0045787	positive regulation of cell cycle	Birc5	IMP		Rat	PMID:18332262|RGD:2293124
Biological Process	GO:0006468	protein phosphorylation	BIRC5	IDA		Human	PMID:21252625
Biological Process	GO:0031503	protein-containing complex localization	BIRC5	IMP		Human	PMID:16239925
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Birc5	IMP	MGI:MGI:3046203	Mouse	PMID:19644667
Biological Process	GO:0007346	regulation of mitotic cell cycle	Birc5	IMP	MGI:MGI:3046203	Mouse	PMID:19644667
Biological Process	GO:0043523	regulation of neuron apoptotic process	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:21546908
Biological Process	GO:0043523	regulation of neuron apoptotic process	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:21546908
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	Birc5	IMP	MGI:MGI:3046203	Mouse	PMID:19644667
Biological Process	GO:0051384	response to glucocorticoid	Birc5	IEP		Rat	PMID:17112829|RGD:2293132
Biological Process	GO:0043434	response to peptide hormone	Birc5	IEP		Rat	PMID:17112829|RGD:2293132
Biological Process	GO:0009410	response to xenobiotic stimulus	Birc5	IEP		Rat	PMID:17727822|RGD:2293130
Biological Process	GO:0007605	sensory perception of sound	BIRC5	IEP		Human	PMID:20627126
Biological Process	GO:0007058	spindle assembly involved in female meiosis II	birc5b	IMP	ZFIN:ZDB-GENO-131003-2	Zfish	PMID:23637620
Biological Process	GO:0001570	vasculogenesis	birc5a	IMP	ZFIN:ZDB-MRPHLNO-070725-1	Zfish	PMID:19323830
Biological Process	GO:0001570	vasculogenesis	birc5b	IMP	ZFIN:ZDB-MRPHLNO-090513-9	Zfish	PMID:19323830

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern