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Birc5
Gene Detail
Symbol

Name
ID
Birc5
baculoviral IAP repeat-containing 5
MGI:1203517
Synonyms
Api4, survivin, TIAP
Feature Type
protein coding gene
Genetic Map
Chromosome 11
82.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:117849251-117855743 bp, + strand
From VEGA annotation of GRCm38

  6493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BIRC5
Protein SuperFamily: Baculoviral IAP repeat-containing protein 5
Gene Tree: Birc5

Human
homologs
BIRC5, baculoviral IAP repeat containing 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 332
neXtProt AC: NX_O15392

Human Synonyms: API4, EPR-1

Human Chr (Location): 17q25; chr17:78214196-78225635 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(9) Targeted(6) Transgenic(2)
 
Homozygous null mutants die during early embryonic development.
 
Interactions
Birc5 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process apoptotic process, cell cycle, ...
Component apical plasma membrane, centriole, ...
Function chaperone binding, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (211)    Tissues (160)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 204
RT-PCR 3
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase birc5.1, birc5.2 ; ZFIN birc5a, birc5b    NEW 
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(97) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003737 (Evidence)
Ensembl Gene Model ENSMUSG00000017716 (Evidence)
Entrez Gene 11799 (Evidence)
UniGene 8552
DFCI TC1589405, TC1574988, TC1619492
DoTS DT.101384264, DT.94262897
NIA Mouse Gene Index U013607
PDB 1M4M
Consensus CDS Project CCDS25694.1, CCDS25695.1
International Mouse Phenotyping Consortium Status Birc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003737 VEGA Gene Model | MGI Sequence Detail 6493 C57BL/6J ±  kb
transcript OTTMUST00000008140 VEGA | MGI Sequence Detail 947 Not Applicable 
polypeptide OTTMUSP00000003966 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
Protein Ontology PR:000004753 baculoviral IAP repeat-containing protein 5
References
(Earliest) J:45193 Adida C, et al., Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol. 1998 Jan;152(1):43-9
(Latest) J:217841 Fukuda S, et al., Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia. 2015 Feb;29(2):433-40
All references(102)
Other
accession IDs
MGI:1196343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory