Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATR
  • Mouse genes Atr
  • Rat genes Atr
  • Zfish genes atr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032405	MutLalpha complex binding	ATR	IDA		Human	PMID:16713580
Molecular Function	GO:0032407	MutSalpha complex binding	ATR	IDA		Human	PMID:16713580
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:P43246	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q8WXE1	Human	PMID:17686975
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q9Y6K9	Human	PMID:18583959
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q99459	Human	PMID:19633697
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q8WXE1	Human	PMID:19889979
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q9BW66	Human	PMID:19889979
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q8WXE1	Human	PMID:20616048
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:O43156	Human	PMID:20810650
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q9Y4R8	Human	PMID:20864032
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:P50750	Human	PMID:20930849
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q8WXE1	Human	PMID:23144622
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q9NY74	Human	PMID:27723717
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:Q9NY74	Human	PMID:27723720
Molecular Function	GO:0005515	protein binding	ATR	IPI	UniProtKB:P04637	Human	PMID:9733515
Molecular Function	GO:0005515	protein binding	Atr	IPI	UniProtKB:Q8BMG1	Mouse	MGI:MGI:4830417|PMID:20801936
Molecular Function	GO:0005515	protein binding	Atr	IPI	UniProtKB:Q9D1M4	Mouse	MGI:MGI:3573962|PMID:15680327
Molecular Function	GO:0004672	protein kinase activity	ATR	IDA		Human	PMID:14657349
Molecular Function	GO:0004672	protein kinase activity	Atr	IDA		Mouse	PMID:15364958
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATR	IDA		Human	PMID:27723717
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATR	IDA		Human	PMID:27723720
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATR	IDA		Human	PMID:9733515
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATR	IDA		Human	PMID:9925639
Cellular Component	GO:0070310	ATR-ATRIP complex	ATR	IPI		Human	PMID:11721054
Cellular Component	GO:0070310	ATR-ATRIP complex	Atr	IPI		Mouse	MGI:MGI:6828548|PMID:11721054
Cellular Component	GO:0005694	chromosome	Atr	IDA		Mouse	MGI:MGI:5319701|PMID:22549958
Cellular Component	GO:0005694	chromosome	Atr	IDA		Mouse	MGI:MGI:5465514|PMID:23039116
Cellular Component	GO:0005794	Golgi apparatus	ATR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001673	male germ cell nucleus	Atr	IDA		Mouse	PMID:31839538
Cellular Component	GO:0005654	nucleoplasm	ATR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016605	PML body	ATR	IDA		Human	PMID:12814551
Cellular Component	GO:0001741	XY body	Atr	IDA		Mouse	PMID:31839538
Cellular Component	GO:0001741	XY body	Atr	IDA		Mouse	PMID:18316482
Biological Process	GO:0071480	cellular response to gamma radiation	ATR	IDA		Human	PMID:9925639
Biological Process	GO:0034644	cellular response to UV	ATR	IMP		Human	PMID:9925639
Biological Process	GO:0051276	chromosome organization	Atr	IMP	MGI:MGI:2176600	Mouse	PMID:10691732
Biological Process	GO:0060271	cilium assembly	atr	IMP	ZFIN:ZDB-MRPHLNO-080801-5	Zfish	PMID:26908596
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	atr	IMP	ZFIN:ZDB-MRPHLNO-080801-5	Zfish	PMID:26908596
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	atr	IMP	ZFIN:ZDB-MRPHLNO-080801-5	Zfish	PMID:26908596
Biological Process	GO:0000077	DNA damage checkpoint signaling	ATR	IDA		Human	PMID:14657349
Biological Process	GO:0000077	DNA damage checkpoint signaling	Atr	IMP		Mouse	PMID:12937170
Biological Process	GO:0006974	DNA damage response	ATR	IDA		Human	PMID:27723717
Biological Process	GO:0006974	DNA damage response	ATR	IDA		Human	PMID:27723720
Biological Process	GO:0006974	DNA damage response	Atr	IDA		Mouse	PMID:15983387
Biological Process	GO:0006281	DNA repair	Atr	IDA		Mouse	PMID:15364958
Biological Process	GO:0007566	embryo implantation	Atr	IMP	MGI:MGI:2176600	Mouse	PMID:10691732
Biological Process	GO:0097694	establishment of RNA localization to telomere	ATR	IMP		Human	PMID:26586433
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	atr	IGI	ZFIN:ZDB-GENO-050428-1,ZFIN:ZDB-MRPHLNO-080801-5,ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0008156	negative regulation of DNA replication	ATR	IMP		Human	PMID:14657349
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ATR	IDA		Human	PMID:9733515
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ATR	IMP		Human	PMID:9925639
Biological Process	GO:1904884	positive regulation of telomerase catalytic core complex assembly	ATR	IMP		Human	PMID:26586433
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	Atr	IMP		Mouse	MGI:MGI:5705431|PMID:26586427
Biological Process	GO:0046777	protein autophosphorylation	ATR	IDA		Human	PMID:9733515
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	ATR	IMP		Human	PMID:21829167
Biological Process	GO:0006468	protein phosphorylation	Atr	IDA		Mouse	PMID:15364958
Biological Process	GO:1901207	regulation of heart looping	atr	IMP	ZFIN:ZDB-MRPHLNO-080801-5	Zfish	PMID:26908596
Biological Process	GO:0043393	regulation of protein binding	Atr	IDA		Mouse	PMID:15983387
Biological Process	GO:0031297	replication fork processing	Atr	IMP		Mouse	MGI:MGI:6467697|PMID:29125140
Biological Process	GO:0090399	replicative senescence	ATR	IMP		Human	PMID:15149599
Biological Process	GO:0046685	response to arsenic-containing substance	Atr	IEP		Rat	PMID:29097844|RGD:150340695
Biological Process	GO:0009410	response to xenobiotic stimulus	Atr	IEP		Rat	PMID:19263217|RGD:2317241

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern