Atr
Gene Detail

Symbol Name ID

Atr ataxia telangiectasia and Rad3 related MGI:108028

Feature Type

protein coding gene

Genetic Map

Chromosome 9

50.27 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:95857597-95951644 bp, + strand From NCBI annotation of GRCm38   94048 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:96916  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atr

Human homologs

Human Homolog		ATR, ataxia telangiectasia and Rad3 related
NCBI Gene ID		545
neXtProt AC		NX_Q13535
Human Synonyms		FCTCS, FRP1, MEC1, SCKL, SCKL1
Human Chr (Location)		3q23; chr3:142168077-142297668 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ATR

Alleles and phenotypes

All alleles(15) : Targeted(8) Gene trapped(7)
 

Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for a knock-out allele exhibit premature death and increased tumor incidence.

 
Human Diseases Modeled Using Mouse Atr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cellular response to gamma radiation, cellular response to UV, ...
Component	chromosome, nucleus, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (63)    Tissues (44)    Images (13)
Theiler Stages: 2, 3, 4, 10, 18, 19, 23, 25, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	41
Northern blot	12
Western blot	3

cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(65)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000032409 (Evidence)
Entrez Gene	245000 (Evidence)
UniGene	212462
DFCI	TC1601163
DoTS	DT.101261445, DT.101355713, DT.101365017, DT.110631173, DT.40166572
NIA Mouse Gene Index	U010868
EC	2.7.11.1
Consensus CDS Project	CCDS52890.1
International Mouse Knockout Project Status	Atr

Sequences

Length	Strain/Species
genomic	245000	NCBI Gene Model | MGI Sequence Detail	94048	C57BL/6J
transcript	NM_019864	RefSeq | MGI Sequence Detail	8074	C57BL/6
polypeptide	Q9JKK8	UniProt | EBI | MGI Sequence Detail	2635	Not Applicable

All sequences(32) RefSeq(2) UniProt(5)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR021133	HEAT, type 2
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR014009	PIK-related kinase
InterPro	IPR003151	PIK-related kinase, FAT
InterPro	IPR003152	PIK-related kinase, FATC
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR012993	UME
Protein Ontology	PR:000004499	serine/threonine-protein kinase ATR

Graphical View of Protein Domain Structure

References

(Earliest) J:35913 Keegan KS, et al., The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes [see comments]. Genes Dev. 1996 Oct 1;10(19):2423-37
(Latest) J:194086 Jung H, et al., RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J Exp Med. 2012 Dec 17;209(13):2409-22
All references(77)

Other accession IDs

MGD-MRK-37064