About   Help   FAQ
Atr Gene Detail
Summary
  • Symbol
    Atr
  • Name
    ataxia telangiectasia and Rad3 related
  • Feature Type
    protein coding gene
  • IDs
    MGI:108028
    NCBI Gene: 245000
Location & Maps
more
  • Sequence Map
    Chr9:95857597-95951644 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94048 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 50.27 cM, cytoband E4
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATR, ATR serine/threonine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATR, ATR serine/threonine kinase
    Orthology source: HomoloGene
  • Synonyms
    FCTCS, FRP1, MEC1, SCKL, SCKL1
  • Links
    NCBI Gene ID: 545
    neXtProt AC: NX_Q13535

  • Chr Location
    3q23; chr3:142449235-142578826 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 96916
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ATR
  • Gene Tree
    Atr
Human Diseases
more
  • Diseases
    1 with Atr mouse models; 2 with human ATR associations

Human Disease Mouse Models
       Seckel Syndrome 1; SCKL1   OMIM: 210600 View 1 model
       Cutaneous Telangiectasia and Cancer Syndrome, Familial; FCTCS   OMIM: 614564
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 8 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    10
  • Genomic Mutations
    1 involving Atr
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for a knock-out allele exhibit premature death and increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047295 VEGA Gene Model | MGI Sequence Detail 94048 C57BL/6J ±  kb
transcript OTTMUST00000122282 VEGA | MGI Sequence Detail 8074 Not Applicable  
polypeptide OTTMUSP00000067136 VEGA | MGI Sequence Detail 2641 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    439 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-37064
References
more
  • Summaries
    All 87
    Developmental Gene Expression 14
    Diseases 2
    Gene Ontology 14
    Phenotypes 35
  • Earliest
    J:35913 Keegan KS, et al., The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes [see comments]. Genes Dev. 1996 Oct 1;10(19):2423-37
  • Latest
    J:228143 Lee SS, et al., ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell Rep. 2015 Nov 24;13(8):1623-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory