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Atr
Gene Detail
 Symbol
Name
ID
Atr
ataxia telangiectasia and Rad3 related
MGI:108028
Feature Type protein coding gene
Genetic Map
Chromosome 9
50.27 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:95857597-95951644 bp, + strand
From VEGA annotation of GRCm38

  94048 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:96916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Atr

Human
homologs
Human Homolog ATR, ATR serine/threonine kinase
NCBI Gene ID 545
neXtProt AC  NX_Q13535
Human Synonyms  FCTCS, FRP1, MEC1, SCKL, SCKL1
Human Chr (Location)  3q23; chr3:142449235-142578826 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATR
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(7) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for a knock-out allele exhibit premature death and increased tumor incidence.
 
Human Diseases Modeled Using Mouse Atr (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to DNA damage stimulus, cellular response to gamma radiation, ...
Component chromosome, nucleus, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (63)    Tissues (45)    Images (13)
Theiler Stages: 2, 3, 4, 10, 18, 19, 23, 25, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 41
Northern blot 12
Western blot 3
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000047295 (Evidence)
Ensembl Gene ModelENSMUSG00000032409 (Evidence)
Entrez Gene245000 (Evidence)
UniGene212462
DFCITC1601163
DoTSDT.101261445, DT.101355713, DT.101365017, DT.110631173, DT.40166572
NIA Mouse Gene IndexU010868
EC2.7.11.1
Consensus CDS ProjectCCDS52890.1
International Mouse Knockout Project StatusAtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047295 VEGA Gene Model | MGI Sequence Detail 94048 C57BL/6J ±  kb
transcript OTTMUST00000122282 VEGA | MGI Sequence Detail 8074 Not Applicable 
polypeptide OTTMUSP00000067136 VEGA | MGI Sequence Detail 2641 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(441 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021133 HEAT, type 2
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR014009 PIK-related kinase
InterPro IPR003151 PIK-related kinase, FAT
InterPro IPR003152 PIK-related kinase, FATC
InterPro IPR011009 Protein kinase-like domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR012993 UME
Protein Ontology PR:000004499 serine/threonine-protein kinase ATR
References (Earliest) J:35913 Keegan KS, et al., The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes [see comments]. Genes Dev. 1996 Oct 1;10(19):2423-37
(Latest) J:211631 Lee Y, et al., Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss. J Neurosci. 2014 Jun 4;34(23):7836-44
All references(85)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-37064

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory