Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Atp2a2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ATP2A2
- Mouse genes Atp2a2
- Rat genes Atp2a2
- Zfish genes atp2a2a,atp2a2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp2a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Atp2a2	IDA		Rat	PMID:12409282\|RGD:724593
Molecular Function	GO:0005509	calcium ion binding	ATP2A2	IDA		Human	PMID:16402920
Molecular Function	GO:0005509	calcium ion binding	Atp2a2	IDA		Rat	PMID:12409282\|RGD:724593
Molecular Function	GO:0019899	enzyme binding	ATP2A2	IPI	UniProtKB:Q08499	Human	PMID:21903937
Molecular Function	GO:0019899	enzyme binding	Atp2a2	IPI	UniProtKB:Q01063	Mouse	MGI:MGI:5442270\|PMID:21903937
Molecular Function	GO:0106222	lncRNA binding	Atp2a2	IPI		Mouse	PMID:29475982
Molecular Function	GO:0031775	lutropin-choriogonadotropic hormone receptor binding	Atp2a2	IPI	RGD:3007	Rat	PMID:17588601\|RGD:2292598
Molecular Function	GO:0005388	P-type calcium transporter activity	ATP2A2	IDA		Human	PMID:16402920
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IMP		Mouse	PMID:29475982
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IDA		Mouse	PMID:12756243
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IMP		Mouse	PMID:31819041
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IDA		Mouse	PMID:9887021
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IDA		Rat	PMID:12409282\|RGD:724593
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a2	IDA		Rat	PMID:21300842\|RGD:6904139
Molecular Function	GO:0086039	P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ATP2A2	IDA		Human	PMID:16402920
Molecular Function	GO:0086039	P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ATP2A2	IDA		Human	PMID:28890335
Molecular Function	GO:0086039	P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:P23327	Human	PMID:17526652
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:P41143	Human	PMID:20528919
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:Q2M3R5	Human	PMID:22084111
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:Q8N394	Human	PMID:24764305
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:O76024	Human	PMID:25274773
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:Q969S6	Human	PMID:25996873
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:P55085	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:O00631\|UniProtKB:P26678	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:O75385	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:Q96GC9	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ATP2A2	IPI	UniProtKB:Q9Y320	Human	PMID:31735293
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:6106240\|PMID:29176668
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:Q5S006\|UniProtKB:Q5S007	Mouse	MGI:MGI:6355873\|PMID:31046837
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:Q924Z5	Mouse	MGI:MGI:4362012\|PMID:14749390
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:A0A1B0GQX2	Mouse	MGI:MGI:6857012\|PMID:35036403
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:B9EIW1	Mouse	MGI:MGI:3760466\|PMID:17526652
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	PR:G5E829	Mouse	PMID:16352659
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	PR:Q3U145	Mouse	PMID:23395171
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	PR:Q9CV60	Mouse	PMID:25640239
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	PR:P27773	Mouse	PMID:23395171
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	PR:P61014	Mouse	PMID:15201433
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:Q9EQU3	Rat	PMID:24610369\|RGD:10047334
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:O70360	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0005515	protein binding	Atp2a2	IPI	UniProtKB:P35570	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0044548	S100 protein binding	ATP2A2	IPI	UniProtKB:P23297	Human	PMID:12804600
Molecular Function	GO:0044325	transmembrane transporter binding	ATP2A2	IPI	UniProtKB:P48995	Human	PMID:18068335
Cellular Component	GO:0061831	apical ectoplasmic specialization	Atp2a2	IDA		Rat	PMID:28486663\|RGD:13782081
Cellular Component	GO:0005783	endoplasmic reticulum	ATP2A2	IDA		Human	PMID:16081076
Cellular Component	GO:0005783	endoplasmic reticulum	ATP2A2	IDA		Human	PMID:30188326
Cellular Component	GO:0005783	endoplasmic reticulum	Atp2a2	IDA		Mouse	PMID:23395171
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ATP2A2	IDA		Human	PMID:11402072
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Atp2a2	IDA		Rat	PMID:20177054\|RGD:7242274
Cellular Component	GO:0016020	membrane	ATP2A2	IDA		Human	PMID:22375059
Cellular Component	GO:0016020	membrane	Atp2a2	IDA		Mouse	PMID:16407245
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Atp2a2	IDA		Rat	PMID:20177054\|RGD:7242274
Cellular Component	GO:0120025	plasma membrane bounded cell projection	Atp2a2	IDA		Rat	PMID:28486663\|RGD:13782081
Cellular Component	GO:0032991	protein-containing complex	Atp2a2	IDA		Rat	PMID:17901878\|RGD:2312630
Cellular Component	GO:0097470	ribbon synapse	Atp2a2	IDA		Mouse	PMID:19932743
Cellular Component	GO:0016529	sarcoplasmic reticulum	ATP2A2	IDA		Human	PMID:12804600
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Mouse	PMID:9038922
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Mouse	PMID:22355118
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Mouse	PMID:29475982
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Rat	PMID:12409282\|RGD:724593
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Rat	PMID:17901878\|RGD:2312630
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a2	IDA		Rat	PMID:8447366\|RGD:7241223
Cellular Component	GO:0012506	vesicle membrane	Atp2a2	IDA		Rat	PMID:21300842\|RGD:6904139
Biological Process	GO:0000045	autophagosome assembly	ATP2A2	IDA		Human	PMID:28890335
Biological Process	GO:0016240	autophagosome membrane docking	ATP2A2	IDA		Human	PMID:28890335
Biological Process	GO:1990036	calcium ion import into sarcoplasmic reticulum	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:1990036	calcium ion import into sarcoplasmic reticulum	Atp2a2	IMP		Mouse	PMID:29475982
Biological Process	GO:1990036	calcium ion import into sarcoplasmic reticulum	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0070588	calcium ion transmembrane transport	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:0070588	calcium ion transmembrane transport	ATP2A2	IDA		Human	PMID:28890335
Biological Process	GO:0070588	calcium ion transmembrane transport	Atp2a2	IDA		Mouse	MGI:MGI:2670850\|PMID:12756243
Biological Process	GO:0070588	calcium ion transmembrane transport	Atp2a2	IMP		Mouse	PMID:31819041
Biological Process	GO:0070588	calcium ion transmembrane transport	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0006816	calcium ion transport	Atp2a2	IDA		Rat	PMID:11595740\|RGD:70642
Biological Process	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Atp2a2	IDA		Mouse	PMID:24137001
Biological Process	GO:0034605	cellular response to heat	Atp2a2	IEP		Rat	PMID:10748035\|RGD:10047286
Biological Process	GO:0034599	cellular response to oxidative stress	Atp2a2	IGI	MGI:MGI:2151208	Mouse	PMID:25452428
Biological Process	GO:0061371	determination of heart left/right asymmetry	atp2a2b	IMP	ZFIN:ZDB-MRPHLNO-191114-4	Zfish	PMID:31075101
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:0006984	ER-nucleus signaling pathway	Atp2a2	IMP		Mouse	PMID:14561754
Biological Process	GO:0001947	heart looping	atp2a2a	IMP	ZFIN:ZDB-MRPHLNO-051228-5	Zfish	PMID:16314582
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ATP2A2	IMP		Human	PMID:18068335
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atp2a2	IMP		Mouse	PMID:21106823
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atp2a2	IDA		Mouse	PMID:9887021
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atp2a2	IMP		Mouse	PMID:12756243
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atp2a2	IGI	MGI:MGI:96074	Mouse	PMID:12756243
Biological Process	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	ATP2A2	IDA		Human	PMID:28890335
Biological Process	GO:0045822	negative regulation of heart contraction	Atp2a2	IGI	MGI:MGI:97622	Mouse	PMID:10555147
Biological Process	GO:1900121	negative regulation of receptor binding	ATP2A2	IMP		Human	PMID:18068335
Biological Process	GO:0070050	neuron cellular homeostasis	Atp2a2	IMP		Mouse	PMID:12756243
Biological Process	GO:0070050	neuron cellular homeostasis	Atp2a2	IGI	MGI:MGI:96074	Mouse	PMID:12756243
Biological Process	GO:0140056	organelle localization by membrane tethering	ATP2A2	IDA		Human	PMID:28890335
Biological Process	GO:0006996	organelle organization	Atp2a2	IMP	MGI:MGI:4415164	Mouse	PMID:22355118
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Atp2a2	IDA		Mouse	PMID:31819041
Biological Process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	Atp2a2	IMP		Mouse	PMID:30188326
Biological Process	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter	Atp2a2	IMP		Mouse	PMID:21106823
Biological Process	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	ATP2A2	IDA		Human	PMID:16402920
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0008016	regulation of heart contraction	atp2a2a	IMP	ZFIN:ZDB-MRPHLNO-051228-5	Zfish	PMID:16314582
Biological Process	GO:0002026	regulation of the force of heart contraction	Atp2a2	IGI	MGI:MGI:97622	Mouse	PMID:10555147
Biological Process	GO:0055119	relaxation of cardiac muscle	Atp2a2	IDA		Rat	PMID:9851937\|RGD:10047146
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Atp2a2	IEP		Rat	PMID:10748035\|RGD:10047286
Biological Process	GO:0032496	response to lipopolysaccharide	Atp2a2	IEP		Rat	PMID:25712896\|RGD:13507309
Biological Process	GO:0043434	response to peptide hormone	Atp2a2	IDA		Rat	PMID:9295312\|RGD:8554624
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	Atp2a2	IMP	MGI:MGI:4415164	Mouse	PMID:22355118
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	Atp2a2	IDA		Rat	PMID:21300842\|RGD:6904139
Biological Process	GO:0003009	skeletal muscle contraction	Atp2a2	IEP		Rat	PMID:21993782\|RGD:13782070
Biological Process	GO:0033292	T-tubule organization	Atp2a2	IMP	MGI:MGI:4415164	Mouse	PMID:22355118
Biological Process	GO:0014883	transition between fast and slow fiber	Atp2a2	IDA		Mouse	PMID:18978355

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.