About   Help   FAQ
Atp2a2
Gene Detail
Symbol

Name
ID
Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
MGI:88110
Synonyms
9530097L16Rik, D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, Serca2a, SERCA2B
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.38 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:122453513-122502225 bp, - strand
From NCBI annotation of GRCm38

  48713 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP2A2
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a2

Human
homologs
ATP2A2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 488
neXtProt AC: NX_P16615

Human Synonyms: ATP2B, DAR, DD, SERCA2

Human Chr (Location): 12q24.11; chr12:110281227-110351093 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ATP2A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(50) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Targeted homozygous mutants are embryonic lethal while heterozygotes show reduced blood pressure and mildly impaired cardiac contractility and relaxation. Aged heterozygotes for one targeted mutation develop squamous cell tumors of the forestomach, esophagus, oral mucosa, tongue, and skin.
 
Human Diseases Modeled in Mice Using Atp2a2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Atp2a2 interacts with 305 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process calcium ion import into sarcoplasmic reticulum, calcium ion transmembrane transport, ...
Component calcium ion-transporting ATPase complex, cell, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (32)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 4
Western blot 14
RT-PCR 12
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase atp2a2 ; ZFIN atp2a2a, atp2a2b    NEW 
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000029467 (Evidence)
Entrez Gene 11938 (Evidence)
DFCI TC1573980, TC1587010, TC1605092, TC1612522, TC1622301, TC1630156, TC1643815
DoTS DT.101263476, DT.101405316, DT.103583598, DT.40177364, DT.55100537, DT.94315327, DT.94409212
NIA Mouse Gene Index U006144
EC 3.6.3.8
Consensus CDS Project CCDS57378.1, CCDS57379.1
International Mouse Phenotyping Consortium Status Atp2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11938 NCBI Gene Model | MGI Sequence Detail 48713 C57BL/6J ±  kb
transcript NR_027838 RefSeq | MGI Sequence Detail 5763 C57BL/6 
polypeptide O55143 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004443 sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:35717 Hawkins C, et al., Sarcoplasmic reticulum calcium pump in cardiac and slow twitch skeletal muscle but not fast twitch skeletal muscle undergoes phosphorylation by endogenous and exogenous Ca2+/calmodulin-dependent protein kinase. Characterization of optimal conditions foralcium pump phosphorylation. J Biol Chem. 1994 Dec 9;269(49):31198-206
(Latest) J:217579 Anderson DM, et al., A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance. Cell. 2015 Jan 28;
All references(154)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1463, MGD-MRK-35783, MGI:107317, MGI:2441754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory