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Atp2a2 Gene Detail
Summary
  • Symbol
    Atp2a2
  • Name
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • Synonyms
    9530097L16Rik, D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, Serca2a, SERCA2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:88110
    NCBI Gene: 11938
  • Alliance
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122453513-122502225 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.38 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88110
protein coding gene Chr5:122453513-122502225 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030053
protein coding gene Chr5:126085200-126137282 (-)
A/J MGP_AJ_G0030018
protein coding gene Chr5:120862592-120911860 (-)
AKR/J MGP_AKRJ_G0029954
protein coding gene Chr5:124757277-124805473 (-)
BALB/cJ MGP_BALBcJ_G0030029
protein coding gene Chr5:122209916-122259539 (-)
C3H/HeJ MGP_C3HHeJ_G0029746
protein coding gene Chr5:125376811-125435498 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030482
protein coding gene Chr5:130936258-130986404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027708
protein coding gene Chr5:115471781-115520349 (-)
CAST/EiJ MGP_CASTEiJ_G0029155
protein coding gene Chr5:124467979-124517084 (-)
CBA/J MGP_CBAJ_G0029716
protein coding gene Chr5:136067326-136119045 (-)
DBA/2J MGP_DBA2J_G0029866
protein coding gene Chr5:120919461-120968563 (-)
FVB/NJ MGP_FVBNJ_G0029822
protein coding gene Chr5:119913282-119962639 (-)
LP/J MGP_LPJ_G0029955
protein coding gene Chr5:126631687-126679897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029853
protein coding gene Chr5:139808935-139859215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030523
protein coding gene Chr5:124357379-124406857 (-)
PWK/PhJ MGP_PWKPhJ_G0028869
protein coding gene Chr5:119698803-119749010 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028706
protein coding gene Chr5:122052805-122102453 (-)
WSB/EiJ MGP_WSBEiJ_G0029230
protein coding gene Chr5:125014999-125064734 (-)



Homology
more
  • Human Ortholog
    ATP2A2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATP2A2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATP2B, DAR, DD, SERCA2
  • Links
    NCBI Gene ID: 488
    neXtProt AC: NX_P16615
    UniProt: P16615

  • Chr Location
    12q24.11; chr12:110281227-110351093 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Atp2a2 mouse models; 2 with human ATP2A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 5 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted homozygous mutants are embryonic lethal while heterozygotes show reduced blood pressure and mildly impaired cardiac contractility and relaxation. Aged heterozygotes for one targeted mutation develop squamous cell tumors of the forestomach, esophagus, oral mucosa, tongue, and skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11938 NCBI Gene Model | MGI Sequence Detail 48713 C57BL/6J ±  kb
    transcript NR_027838 RefSeq | MGI Sequence Detail 5763 C57BL/6  
    polypeptide O55143 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 24
      Primer pair 3
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1463, MGD-MRK-35783, MGI:107317, MGI:2441754
    References
    more
    • Summaries
      All 206
      Developmental Gene Expression 55
      Diseases 1
      Gene Ontology 27
      Phenotypes 63
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266272 Hilse KE, et al., The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Front Physiol. 2018;9:747

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory