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Gene Detail
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms 9530097L16Rik, D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, SERCA2B
Feature Type protein coding gene
Genetic Map
Chromosome 5
62.38 cM, cytoband F
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr5:122453513-122502225 bp, - strand
From NCBI annotation of GRCm38

  48713 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:80167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a2

Human Homolog ATP2A2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
NCBI Gene ID 488
neXtProt AC  NX_P16615
Human Synonyms  ATP2B, DAR, DD, SERCA2
Human Chr (Location)  12q24.11; chr12:110281227-110351093 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATP2A2
alleles, and
All mutations/alleles(56) : Gene trapped(50) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Targeted homozygous mutants are embryonic lethal while heterozygotes show reduced blood pressure and mildly impaired cardiac contractility and relaxation. Aged heterozygotes for one targeted mutation develop squamous cell tumors of the forestomach, esophagus, oral mucosa, tongue, and skin.
Human Diseases Modeled Using Mouse Atp2a2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Atp2a2 interacts with 305 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
All GO classifications: (52 annotations)
Process ATP catabolic process, calcium ion transmembrane transport, ...
Component cell, endoplasmic reticulum, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Literature Summary: (41 records)
Data Summary: Results (32)    Tissues (14)    Images (3)
Theiler Stages: 11, 15, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 2
Northern blot 4
Western blot 14
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(28) Genomic(2) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
Ensembl Gene ModelENSMUSG00000029467 (Evidence)
Entrez Gene11938 (Evidence)
DFCITC1573980, TC1587010, TC1605092, TC1612522, TC1622301, TC1630156, TC1643815
DoTSDT.101263476, DT.101405316, DT.103583598, DT.40177364, DT.55100537, DT.94315327, DT.94409212
NIA Mouse Gene IndexU006144
Consensus CDS ProjectCCDS57378.1, CCDS57379.1
International Mouse Knockout Project StatusAtp2a2
Representative SequencesLengthStrain/SpeciesFlank
genomic 11938 NCBI Gene Model | MGI Sequence Detail 48713 C57BL/6J ±  kb
transcript NR_027838 RefSeq | MGI Sequence Detail 5763 C57BL/6 
polypeptide O55143 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
InterPro IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004443 sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Graphical View of Protein Domain Structure
References (Earliest) J:34252 Hsu DK, et al., Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1483-91
(Latest) J:210465 Wahlquist C, et al., Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 2014 Apr 24;508(7497):531-5
All references(151)
Disease annotation references (1)
accession IDs
MGD-MRK-1463, MGD-MRK-35783, MGI:107317, MGI:2441754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory