Atp2a2
Gene Detail

Symbol Name ID

Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 MGI:88110

Synonyms

9530097L16Rik, D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, SERCA2a, SERCA2B

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.38 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:122453513-122502225 bp, - strand From NCBI annotation of GRCm38   48713 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:80167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a2

Human homologs

Human Homolog		ATP2A2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
NCBI Gene ID		488
neXtProt AC		NX_P16615
Human Synonyms		ATP2B, DAR, DD, SERCA2
Human Chr (Location)		12q24.11; chr12:110719032-110788898 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ATP2A2

Alleles and phenotypes

All alleles(55) : Targeted(5) Gene trapped(50)
 

Targeted homozygous mutants are embryonic lethal while heterozygotes show reduced blood pressure and mildly impaired cardiac contractility and relaxation. Aged heterozygotes for one targeted mutation develop squamous cell tumors of the forestomach, esophagus, oral mucosa, tongue, and skin.

 
Human Diseases Modeled Using Mouse Atp2a2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	ATP catabolic process, calcium ion transmembrane transport, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (40 records)
Data Summary: Results (32)    Tissues (12)    Images (3)
Theiler Stages: 11, 15, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	2
Northern blot	4
Western blot	14
RT-PCR	12

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(2) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000029467 (Evidence)
Entrez Gene	11938 (Evidence)
DFCI	TC1573980, TC1587010, TC1605092, TC1612522, TC1622301, TC1630156, TC1643815
DoTS	DT.101263476, DT.101405316, DT.103583598, DT.40177364, DT.55100537, DT.94315327, DT.94409212
NIA Mouse Gene Index	U006144
EC	3.6.3.8
Consensus CDS Project	CCDS57378.1, CCDS57379.1
International Mouse Knockout Project Status	Atp2a2

Sequences

Length	Strain/Species
genomic	11938	NCBI Gene Model | MGI Sequence Detail	48713	C57BL/6J
transcript	NR_027838	RefSeq | MGI Sequence Detail	5763	C57BL/6
polypeptide	O55143	UniProt | EBI | MGI Sequence Detail	1044	Not Applicable

All sequences(74) RefSeq(5) UniProt(4)

Polymorphisms

SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005782	Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
InterPro	IPR001757	Cation-transporting P-type ATPase
InterPro	IPR006068	Cation-transporting P-type ATPase, C-terminal
InterPro	IPR004014	Cation-transporting P-type ATPase, N-terminal
InterPro	IPR023214	HAD-like domain
InterPro	IPR008250	P-type ATPase, A domain
InterPro	IPR023299	P-type ATPase, cytoplasmic domain N
InterPro	IPR018303	P-type ATPase, phosphorylation site
InterPro	IPR023298	P-type ATPase, transmembrane domain
Protein Ontology	PR:000004443	sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:34252 Hsu DK, et al., Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1483-91
(Latest) J:192707 He A, et al., Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 3;110(3):406-15
All references(139)

Other accession IDs

MGD-MRK-1463, MGD-MRK-35783, MGI:107317, MGI:2441754