Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATP2A1
  • Mouse genes Atp2a1
  • Rat genes Atp2a1
  • Zfish genes atp2a1,atp2a1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp2a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Atp2a1	IDA		Rat	PMID:12409282|RGD:724593
Molecular Function	GO:0005509	calcium ion binding	ATP2A1	IMP		Human	PMID:9405806
Molecular Function	GO:0005509	calcium ion binding	Atp2a1	IDA		Mouse	PMID:27923914
Molecular Function	GO:0005509	calcium ion binding	Atp2a1	IDA		Rat	PMID:12409282|RGD:724593
Molecular Function	GO:0005509	calcium ion binding	Atp2a1	IDA		Rat	PMID:19029185|RGD:2313265
Molecular Function	GO:0030899	calcium-dependent ATPase activity	Atp2a1	IDA		Rat	PMID:9843705|RGD:14995324
Molecular Function	GO:0005338	nucleotide-sugar transmembrane transporter activity	Atp2a1	IDA		Rat	PMID:12409282|RGD:724593
Molecular Function	GO:0005388	P-type calcium transporter activity	ATP2A1	IDA		Human	PMID:8729696
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a1	IDA		Rat	PMID:12222829|RGD:727704
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a1	IDA		Rat	PMID:12409282|RGD:724593
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a1	IDA		Rat	PMID:9843705|RGD:14995324
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2a1	IDA		Rat	PMID:9887021|RGD:8554277
Molecular Function	GO:0005515	protein binding	ATP2A1	IPI	UniProtKB:Q96GC9	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ATP2A1	IPI	UniProtKB:P35568	Human	PMID:9295312
Molecular Function	GO:0005515	protein binding	ATP2A1	IPI	UniProtKB:P35570	Human	PMID:9295312
Molecular Function	GO:0005515	protein binding	Atp2a1	IPI	UniProtKB:P0DN83|UniProtKB:P61014	Mouse	MGI:MGI:6304509|PMID:30299255
Molecular Function	GO:0005515	protein binding	Atp2a1	IPI	UniProtKB:P0DN83	Mouse	MGI:MGI:5751610|PMID:26816378
Molecular Function	GO:0005515	protein binding	Atp2a1	IPI	PR:Q9CV60	Mouse	PMID:25640239
Molecular Function	GO:0005515	protein binding	Atp2a1	IPI	UniProtKB:O70360	Rat	PMID:9295312|RGD:8554624
Molecular Function	GO:0005515	protein binding	Atp2a1	IPI	UniProtKB:P35570	Rat	PMID:9295312|RGD:8554624
Molecular Function	GO:0042803	protein homodimerization activity	ATP2A1	IPI	UniProtKB:O14983	Human	PMID:11402072
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Atp2a1	IDA		Rat	PMID:14506614|RGD:1581765
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a1	IDA		Mouse	PMID:11784029
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a1	IDA		Rat	PMID:12409282|RGD:724593
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a1	IDA		Rat	PMID:19029185|RGD:2313265
Cellular Component	GO:0016529	sarcoplasmic reticulum	Atp2a1	IDA		Rat	PMID:8447366|RGD:7241223
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Atp2a1	IDA		Mouse	MGI:MGI:5751610|PMID:26816378
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Atp2a1	IDA		Mouse	PMID:25640239
Biological Process	GO:0008637	apoptotic mitochondrial changes	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0070509	calcium ion import	ATP2A1	IMP		Human	PMID:8040329
Biological Process	GO:0070588	calcium ion transmembrane transport	Atp2a1	IDA		Rat	PMID:9843705|RGD:14995324
Biological Process	GO:0006816	calcium ion transport	ATP2A1	IMP		Human	PMID:9405806
Biological Process	GO:0006816	calcium ion transport	Atp2a1	IDA		Rat	PMID:9887021|RGD:8554277
Biological Process	GO:0006816	calcium ion transport	Atp2a1	IDA		Rat	PMID:12222829|RGD:727704
Biological Process	GO:0006874	intracellular calcium ion homeostasis	atp2a1	IMP	ZFIN:ZDB-GENO-980202-1119	Zfish	PMID:15581877
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0051659	maintenance of mitochondrion location	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	ATP2A1	IMP		Human	PMID:11402072
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0045932	negative regulation of muscle contraction	atp2a1	IMP	ZFIN:ZDB-GENO-980202-1119	Zfish	PMID:15469975
Biological Process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	ATP2A1	IMP		Human	PMID:11402072
Biological Process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	ATP2A1	IDA		Human	PMID:12479237
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0006937	regulation of muscle contraction	atp2a1	IMP	ZFIN:ZDB-GENO-980202-1119	Zfish	PMID:15581877
Biological Process	GO:0006937	regulation of muscle contraction	atp2a1	IMP		Zfish	PMID:15581877
Biological Process	GO:0090076	relaxation of skeletal muscle	ATP2A1	IDA		Human	PMID:8841193
Biological Process	GO:0090076	relaxation of skeletal muscle	atp2a1	IMP	ZFIN:ZDB-GENO-041029-1	Zfish	PMID:15469975
Biological Process	GO:0090076	relaxation of skeletal muscle	atp2a1	IMP	ZFIN:ZDB-GENO-041029-2	Zfish	PMID:15469975
Biological Process	GO:0090076	relaxation of skeletal muscle	atp2a1	IMP	ZFIN:ZDB-GENO-980202-1119	Zfish	PMID:15469975
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ATP2A1	IMP		Human	PMID:19061639
Biological Process	GO:0009612	response to mechanical stimulus	atp2a1	IMP		Zfish	PMID:15581877
Biological Process	GO:0009612	response to mechanical stimulus	atp2a1	IMP	ZFIN:ZDB-GENO-980202-1119	Zfish	PMID:15581877
Biological Process	GO:0043434	response to peptide hormone	Atp2a1	IDA		Rat	PMID:9295312|RGD:8554624
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	Atp2a1	IDA		Rat	PMID:19029185|RGD:2313265

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern