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Atp2a1
Gene Detail
 Symbol
Name
ID
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
MGI:105058
Synonyms SERCA1
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:126445858-126463108 bp, - strand
From VEGA annotation of GRCm38

  17251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a1

Human
homologs
Human Homolog ATP2A1, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
NCBI Gene ID 487
neXtProt AC  NX_O14983
Human Synonyms  ATP2A, SERCA1
Human Chr (Location)  16p12.1; chr16:28878488-28904509 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATP2A1
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in perinatal lethality. Mutant neonates display respiratory distress, progressive cyanosis, and die within 30 minutes-2 hours after birth. Lung tissues and the diaphragm muscle show aberrant morphology.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apoptotic mitochondrial changes, ATP catabolic process, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function ATP binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (101)    Tissues (13)    Images (24)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 88
Western blot 13
cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025329 (Evidence)
Ensembl Gene ModelENSMUSG00000030730 (Evidence)
Entrez Gene11937 (Evidence)
UniGene35134
DFCITC1576946
DoTSDT.94292914
NIA Mouse Gene IndexU029244
EC3.6.3.8
Consensus CDS ProjectCCDS40125.1
International Mouse Knockout Project StatusAtp2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025329 VEGA Gene Model | MGI Sequence Detail 17251 C57BL/6J ±  kb
transcript OTTMUST00000062344 VEGA | MGI Sequence Detail 3477 Not Applicable 
polypeptide OTTMUSP00000030719 VEGA | MGI Sequence Detail 994 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004442 sarcoplasmic/endoplasmic reticulum calcium ATPase 1
References (Earliest) J:19385 Schleef M, et al., Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscul Disord. 1994 May;4(3):205-17
(Latest) J:187997 Chamberlain CM, et al., Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise. Hum Mol Genet. 2012 Nov 1;21(21):4645-54
All references(58)
Other
accession IDs
MGD-MRK-32097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory