Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASIC2
  • Mouse genes Asic2
  • Rat genes Asic2
  • Zfish genes asic2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Asic2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Asic2	IDA		Mouse	PMID:9368048
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Asic2	IDA		Mouse	PMID:11306621
Molecular Function	GO:0005261	monoatomic cation channel activity	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:11854527
Molecular Function	GO:0005261	monoatomic cation channel activity	Asic2	IDA		Mouse	PMID:11854527
Molecular Function	GO:0005216	monoatomic ion channel activity	Asic2	IDA		Mouse	PMID:18256271
Molecular Function	GO:0005216	monoatomic ion channel activity	Asic2	IDA		Rat	PMID:14976185|RGD:1358269
Molecular Function	GO:0022839	monoatomic ion gated channel activity	Asic2	IDA		Mouse	PMID:14960591
Molecular Function	GO:0022839	monoatomic ion gated channel activity	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:14960591
Molecular Function	GO:0005515	protein binding	ASIC2	IPI	UniProtKB:Q9NRD5	Human	PMID:11802773
Molecular Function	GO:0005515	protein binding	Asic2	IPI	PR:Q62108	Mouse	PMID:19571134
Molecular Function	GO:0005515	protein binding	Asic2	IPI	MGI:MGI:1194915	Mouse	PMID:19571134
Molecular Function	GO:0005515	protein binding	Asic2	IPI	UniProtKB:D4A100	Rat	PMID:17167420|RGD:13432298
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Asic2	IDA		Rat	PMID:9368048|RGD:1298619
Cellular Component	GO:0043197	dendritic spine	Asic2	IDA		Mouse	PMID:19571134
Cellular Component	GO:0016020	membrane	Asic2	IDA		Mouse	PMID:9368048
Cellular Component	GO:0043005	neuron projection	Asic2	IDA		Mouse	PMID:15537887
Cellular Component	GO:0043025	neuronal cell body	Asic2	IDA		Mouse	PMID:15537887
Cellular Component	GO:0005886	plasma membrane	Asic2	IDA		Mouse	PMID:11854527
Cellular Component	GO:0005886	plasma membrane	Asic2	IDA		Mouse	PMID:11306621
Cellular Component	GO:0045202	synapse	Asic2	IDA		Mouse	PMID:19571134
Biological Process	GO:0071468	cellular response to acidic pH	Asic2	IDA		Rat	PMID:12736332|RGD:1298620
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Asic2	IDA		Rat	PMID:12736332|RGD:1298620
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:11069180
Biological Process	GO:0051649	establishment of localization in cell	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:15470133
Biological Process	GO:0051649	establishment of localization in cell	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:14960591
Biological Process	GO:0051649	establishment of localization in cell	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19590043
Biological Process	GO:0051649	establishment of localization in cell	Asic2	IDA		Mouse	PMID:18256271
Biological Process	GO:0098655	monoatomic cation transmembrane transport	Asic2	IDA		Mouse	MGI:MGI:2158965|PMID:11854527
Biological Process	GO:0006812	monoatomic cation transport	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:11854527
Biological Process	GO:0006812	monoatomic cation transport	Asic2	IDA		Mouse	PMID:11854527
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:15470133
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:14960591
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19590043
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic2	IDA		Mouse	PMID:14960591
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic2	IDA		Mouse	PMID:18256271
Biological Process	GO:0043066	negative regulation of apoptotic process	Asic2	IMP	MGI:MGI:3043849	Mouse	PMID:14762118
Biological Process	GO:0007602	phototransduction	Asic2	IMP	MGI:MGI:3043849	Mouse	PMID:14762118
Biological Process	GO:2001259	positive regulation of cation channel activity	Asic2	IDA		Rat	PMID:12736332|RGD:1298620
Biological Process	GO:0051965	positive regulation of synapse assembly	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19571134
Biological Process	GO:0035418	protein localization to synapse	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19571134
Biological Process	GO:0042391	regulation of membrane potential	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19590043
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:14960591
Biological Process	GO:0003026	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:20064394
Biological Process	GO:0019229	regulation of vasoconstriction	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:18296560
Biological Process	GO:0010447	response to acidic pH	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:11854527
Biological Process	GO:0010447	response to acidic pH	Asic2	IDA		Mouse	PMID:11306621
Biological Process	GO:0010447	response to acidic pH	Asic2	IDA		Mouse	PMID:11854527
Biological Process	GO:0009612	response to mechanical stimulus	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:11069180
Biological Process	GO:0048545	response to steroid hormone	asic2	IEP		Zfish	PMID:28265462
Biological Process	GO:0007605	sensory perception of sound	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:15537887
Biological Process	GO:0050915	sensory perception of sour taste	ASIC2	IMP		Human	PMID:19812697
Biological Process	GO:0006814	sodium ion transport	Asic2	IDA		Mouse	PMID:11306621
Biological Process	GO:0006814	sodium ion transport	Asic2	IDA		Mouse	PMID:9368048
Biological Process	GO:0006814	sodium ion transport	Asic2	IDA		Rat	PMID:9368048|RGD:1298619
Biological Process	GO:0007416	synapse assembly	Asic2	IMP	MGI:MGI:2180111	Mouse	PMID:19571134

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern