Asic2
Gene Detail

Symbol Name ID

Asic2 acid-sensing (proton-gated) ion channel 2 MGI:1100867

Synonyms

Accn1, BNaC1a, BNC1, Mdeg

Feature Type

protein coding gene

Genetic Map

Chromosome 11

48.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:80880169-81968457 bp, - strand From VEGA annotation of GRCm38   1088289 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Asic2

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(8)
 

Mice homozygous for a knock-out allele exhibit decreased mechanoreceptor and spiral ganglion electrophysiology and decreased pressure-induced blood vessel constriction. Mice homozygous for a different knock-out allele exhibit retinal degeneration and abnormal eye electrophysiology.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	cation transport, detection of mechanical stimulus involved in sensory perception, ...
Component	dendritic spine, integral to membrane, ...
Function	cation channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (141)    Tissues (34)    Images (24)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	137
Northern blot	4

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000859 (Evidence)
Ensembl Gene Model	ENSMUSG00000020704 (Evidence)
Entrez Gene	11418 (Evidence)
UniGene	234998
DFCI	TC1582655, TC1593488
DoTS	DT.101306412, DT.55176792, DT.94233397
NIA Mouse Gene Index	U033166
Consensus CDS Project	CCDS25137.1, CCDS36243.1
International Mouse Knockout Project Status	Asic2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000859	VEGA Gene Model | MGI Sequence Detail	1088289	C57BL/6J
transcript	OTTMUST00000001668	VEGA | MGI Sequence Detail	3436	Not Applicable
polypeptide	OTTMUSP00000000789	VEGA | MGI Sequence Detail	563	Not Applicable

All sequences(32) RefSeq(4) UniProt(4)

Polymorphisms

PCR(1) : SNPs(3763 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004724	Epithelial sodium channel
InterPro	IPR001873	Na+ channel, amiloride-sensitive
InterPro	IPR020903	Na+ channel, amiloride-sensitive, conserved site
Protein Ontology	PR:000003614	amiloride-sensitive cation channel 1, neuronal

References

(Earliest) J:44171 Lingueglia E, et al., A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 1997 Nov 21;272(47):29778-83
(Latest) J:190140 Petroff E, et al., Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels. Biochem Biophys Res Commun. 2012 Oct 5;426(4):511-5
All references(53)