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Asic2
Gene Detail
Symbol

Name
ID
Asic2
acid-sensing (proton-gated) ion channel 2
MGI:1100867
Synonyms
Accn1, BNaC1a, BNC1, Mdeg
Feature Type
protein coding gene
Genetic Map
Chromosome 11
48.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:80880169-81968457 bp, - strand
From VEGA annotation of GRCm38

  1088289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog

Gene Tree: Asic2

Human
homologs
Human Homolog ASIC2, acid-sensing (proton-gated) ion channel 2
NCBI Gene ID 40
neXtProt AC  NX_Q16515
Human Synonyms  ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG
Human Chr (Location)  17q12; chr17:33013087-34156806 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit decreased mechanoreceptor and spiral ganglion electrophysiology and decreased pressure-induced blood vessel constriction. Mice homozygous for a different knock-out allele exhibit retinal degeneration and abnormal eye electrophysiology.
 
Interactions
Asic2 interacts with 173 markers (Mir7-1, Mir19a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cation transmembrane transport, cation transport, ...
Component dendritic spine, integral component of membrane, ...
Function cation channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (141)    Tissues (34)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
Northern blot 4
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000859 (Evidence)
Ensembl Gene ModelENSMUSG00000020704 (Evidence)
Entrez Gene11418 (Evidence)
UniGene234998
DFCITC1593488, TC1582655
DoTSDT.101306412, DT.94233397, DT.55176792
NIA Mouse Gene IndexU033166
Consensus CDS ProjectCCDS25137.1, CCDS36243.1
International Mouse Knockout Project StatusAsic2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000859 VEGA Gene Model | MGI Sequence Detail 1088289 C57BL/6J ±  kb
transcript OTTMUST00000001668 VEGA | MGI Sequence Detail 3436 Not Applicable 
polypeptide OTTMUSP00000000789 VEGA | MGI Sequence Detail 563 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(5391 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5397)
Protein-related
information
ResourceIDDescription
InterPro IPR004724 Epithelial sodium channel
InterPro IPR001873 Na+ channel, amiloride-sensitive
InterPro IPR020903 Na+ channel, amiloride-sensitive, conserved site
Protein Ontology PR:000003614 acid-sensing ion channel 2
References
(Earliest) J:44171 Lingueglia E, et al., A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 1997 Nov 21;272(47):29778-83
(Latest) J:211633 Du J, et al., Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8961-6
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory