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Asic2 Gene Detail
Summary
  • Symbol
    Asic2
  • Name
    acid-sensing (proton-gated) ion channel 2
  • Synonyms
    Accn1, BNaC1a, BNC1, Mdeg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100867
    NCBI Gene: 11418
  • Gene Overview
    MyGene.info: ASIC2
Location & Maps
more
  • Sequence Map
    Chr11:80880169-81968457 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1088289 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 48.43 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ASIC2, acid sensing ion channel subunit 2
  • Vertebrate Orthologs
    4
  • Human Ortholog
    ASIC2, acid sensing ion channel subunit 2
    Orthology source: HomoloGene
  • Synonyms
    ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG
  • Links
    NCBI Gene ID: 40
    neXtProt AC: NX_Q16515

  • Chr Location
    17q12; chr17:33013087-34156806 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    2 involving Asic2
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit decreased mechanoreceptor and spiral ganglion electrophysiology and decreased pressure-induced blood vessel constriction. Mice homozygous for a different knock-out allele exhibit retinal degeneration and abnormal eye electrophysiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000859 VEGA Gene Model | MGI Sequence Detail 1088289 C57BL/6J ±  kb
transcript OTTMUST00000001668 VEGA | MGI Sequence Detail 3436 Not Applicable  
polypeptide OTTMUSP00000000789 VEGA | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5381 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003614 acid-sensing ion channel 2
  • InterPro Domains
    IPR004724 Epithelial sodium channel
    IPR001873 Na+ channel, amiloride-sensitive
    IPR020903 Na+ channel, amiloride-sensitive, conserved site
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 5
    Gene Ontology 17
    Phenotypes 40
  • Earliest
    J:44171 Lingueglia E, et al., A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 1997 Nov 21;272(47):29778-83
  • Latest
    J:220575 Price MP, et al., Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes Brain Behav. 2014 Feb;13(2):179-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory