Sequence Detail

ID/Version

Q925H0 Q61203 Q5SUU2 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-04-09

Sequence description from provider

RecName: Full=Acid-sensing ion channel 2 {ECO:0000305|PubMed:9368048}; Short=ASIC2;AltName: Full=Amiloride-sensitive cation channel 1, neuronal;AltName: Full=Brain sodium channel 1 {ECO:0000303|PubMed:11306621}; Short=BNC1 {ECO:0000303|Pub

Provider

SWISS-PROT

Sequence

Polypeptide 512 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Asic2	acid-sensing ion channel 2	74	101	3	19

Sequence references in MGI

J:44171 Lingueglia E, et al., A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 1997 Nov 21;272(47):29778-83
J:68839 Garcia-Anoveros J, et al., Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci. 2001 Apr 15;21(8):2678-86
J:76712 Price MP, et al., The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 2000 Oct 26;407(6807):1007-11
J:90117 Ettaiche M, et al., Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci. 2004 Feb 4;24(5):1005-12
J:96521 Peng BG, et al., Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. J Neurosci. 2004 Nov 10;24(45):10167-75
J:105150 McIlwrath SL, et al., The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience. 2005;131(2):499-511
J:124264 Askwith CC, et al., Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. J Biol Chem. 2004 Apr 30;279(18):18296-305
J:157720 Lu Y, et al., The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron. 2009 Dec 24;64(6):885-97
J:188623 Brand J, et al., A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J. 2012 Aug 29;31(17):3635-46