Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANGPTL2
  • Mouse genes Angptl2
  • Rat genes Angptl2
  • Zfish genes angptl2a,angptl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Angptl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ANGPTL2	IPI	UniProtKB:Q8N423	Human	PMID:22660330
Molecular Function	GO:0005515	protein binding	ANGPTL2	IPI	UniProtKB:Q8N423	Human	PMID:24899623
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ANGPTL2	HDA		Human	PMID:28675934
Cellular Component	GO:0070062	extracellular exosome	ANGPTL2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ANGPTL2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Angptl2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0001525	angiogenesis	angptl2b	IGI	ZFIN:ZDB-MRPHLNO-051019-1,ZFIN:ZDB-MRPHLNO-051020-1	Zfish	PMID:16174743
Biological Process	GO:0060216	definitive hemopoiesis	angptl2b	IGI	ZFIN:ZDB-GENE-040724-269	Zfish	PMID:25714926
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	angptl2b	IGI	ZFIN:ZDB-GENE-040426-780,ZFIN:ZDB-GENE-040724-269	Zfish	PMID:25714926
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	angptl2b	IGI	ZFIN:ZDB-GENE-040724-269	Zfish	PMID:25714926
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	angptl2b	IGI	ZFIN:ZDB-GENE-040724-269	Zfish	PMID:25714926

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern